Amide derivatives and nociceptin antagonists

a technology of nociceptin and amide derivatives, applied in the field of nociceptin antagonists, can solve the problems of many unknown parts in the central action mechanism, considered ineffective for visceralgia, etc., and achieve the effect of free of marked side effects
US20060030565A1Inactive Publication Date: 2006-02-09JAPAN TOBACCO INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
JAPAN TOBACCO INC
Publication Date
2006-02-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a compound of the formula [1′]wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a nociceptin antagonist containing a novel amide derivative or a pharmaceutically acceptable salt thereof. More particularly, the present invention relates to an analgesic containing,-as an active ingredient, a novel amide derivative or a pharmaceutically acceptable salt thereof, which show analgesic effect as nociceptin antagonist by selectively acting on an opioid receptor like-1 receptor and which are useful for the treatment of pain, particularly sharp pain or pain caused by sensory nerve abnormality, such as hyperalgesia and allodynia. The present invention moreover relates to a novel use of a certain kind of amide derivative as a nociceptin antagonist and analgesic. BACKGROUND ART

[0002] Pain is a sensation felt by anybody and is an important vital signal or alarm signal.

[0003] Pain caused by injury, surgery, inflammation and the like, as well as chronic pain stemming from injury, dysfunction and the like of nerves after...

Claims

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