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Disinfecting and antimicrobial compositions

a technology of antimicrobial compositions and compositions, applied in the field of disinfecting compositions, can solve the problems of unfavorable human and animal health, and unfavorable human and animal health, and achieve the effect of reducing or eliminating the risk of infection and illness

Inactive Publication Date: 2006-08-03
LOPES JOHN ALEX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008] In accordance herewith, there is provided a class of chemical compositions predicated on chemical agents that can be used to prepare antimicrobial, microbicidal and disinfecting compositions for cleaning fresh fruits, vegetables, seeds, sprouts, meats, poultry, eggs, carcasses, other food surfaces and surgical instruments as well as body parts in order to prevent, to reduce or to eliminate the risk of infection and illness arising from both chemical residues and microorganisms spread by or carried on the food, food contact and body surfaces.
[0017] The composition hereof may include other compatible ingredients, which do not reduce or interfere with the antimicrobial and cleaning properties such as for example, urea, to enhance the cleaning properties of the composition.
[0019] The present cleaning compositions can be prepared in either concentrated liquid or powder forms as well as in gel form, or as in a foam, thus, giving operational flexibility for use. The concentrate can be further diluted to form a use composition.

Problems solved by technology

However, these chemicals also react with organic food material and produce unknown chemical residues often harmful to human and animal health.
These antimicrobial products do not have detergent action or cleaning properties.
Some other cleaning preparations that are allowed on food either do not have antimicrobial and microbicidal properties or are not safe enough as the ingredients are not considered by the FDA as GRAS or food additive safe.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example i

[0047] This example illustrates the sporicidal activity of lactic esters against Bacillus coagulans spores.

[0048] One ml each of a mixture of ethyl lactate and butyl lactate (1:1) was mixed, at room temperature, with 0.1 ml of B. coagulans spore suspension containing 1.5×106 spores per ml and incubated at room temperature for five minutes. B. coagulans exhibit very high heat resistance and is used as an indicator for bacteria in a heat sterilization process.

[0049] After five minutes 1 ml of the test mixture was mixed with 10 mls of Butterfield's buffer, at pH 7.0. Then, 0.1 ml of the buffered test mixture was plated on a plate count in agar. The colonies were counted after 48 hrs of incubation at room temperature.

[0050] The following table, Table I, shows the results of the colony counting.

TABLE 1Sporicidal Activity of Lactic EstersStarting Number of Spores in the inoculum:1.5 × 106 / mlNumber of spores in the test (diluted 1:10):1.5 × 105 / mlNumber of spores in the buffer (dilute...

example ii

[0052] This example illustrates the microbicidal activity of ethyl lactate and butyl lactate against vegetative bacteria. Example II, also, shows the minimum lethal activity (MLC) of these lactic esters against both gram positive and gram-negative bacteria.

[0053] The microbicidal activity was further investigated by determining the minimum inhibitory concentration (MIC) and minimum lethal concentrations (MLC) of these esters.

[0054] The tests were carried out in 10 ml of brain heart infusion broth. The esters were serially diluted in brain heart infusion broth of samples of, 0.1, 0.2, 0.3, 0.4 and 0.5 / 10 ml and challenged with 0.1 ml of 1 / 100 dilution of 24 hr old brain heart infusion bacterial culture. The lowest concentration determined the minimum inhibitory concentration (MIC). The samples were observed after 48 hrs at 37° C. A loopful from tubes without growth were plated on BHI agar plates and observed for growth for 24 to 48 hrs at 37° C. The samples with the lowest concentr...

example iii

[0057] This example illustrates the enhancement of antimicrobial activity of lactic esters by the incorporation of additional components therewith.

[0058] A series of samples of (a) methyl lactate, (b) ethyl lactate and (c) butyl lactate, alone, and in admixture with varying amounts of decyl lactate and sodium dodecyl sulfates were used to test minimum inhibitory activity (MIC) by the method described in Example II, against the cultures of E. coli 0157 H7, Listeria monocytogenes, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa. Tables 4 and 5 show that decyl lactate and sodium dodecyl sulfate enhanced inhibitory activities against the test bacteria.

TABLE 4Enhancement of Antimicrobial Properties (MIC)of Ethyl lactate by Decyl lactylateTest OrganismTest Compound1%2%3%4%5%E. coli 0157 H7EL+++−−EL + DL++−−−Listeria monocytogenesEL+++++EL + DL−−−−Staphylococcus aureusEL+++++EL + DL−−−−−Salmonella typhiEL+++−−EL + DL++−−

MIC = Minimum Inhibitory Concentration,;

+ = gr...

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Abstract

Broad spectrum disinfecting and microbicidal compositions of biodegradable and environmentally friendly compositions containing esters formed from fatty organic alcohols and fatty carboxylic acids. These compositions display activities against the most resistant microbial forms including bacterial spores. The preparations can be used in health care, food processing, personal care and other industries where the use of harsh oxidizing chemicals is undesirable.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a completion application of copending U.S. Provisional Patent Application Ser. No. 60 / 647,464, filed on Jan. 28, 2005, for “Disinfecting and Antimicrobial Compositions”, the entire disclosure of which is hereby incorporated by reference.BACKGROUND OF INVENTION [0002] 1. Field of Invention [0003] This invention relates to cleaning compositions for body, food, and food contact surfaces which reduce the risk of illness caused by harmful chemical residues, infectious agents and other disease causing and spoilage microbial agents. More particularly, the present invention provides chemical disinfecting compositions which reduce injury or inflammation to the skin. Even more particularly the present invention concerns disinfecting compositions which use safe and non-toxic chemical agents selected from alcohol esters of ethyl lactate and its homologs for preparing products with cleaning, solubilizing, antimicrobial and microb...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/22A01N25/00
CPCA01N37/36A23L3/3508A23L3/3517A23L3/3535A23L3/358A01N37/02A61K31/22A01N25/30A01N2300/00
Inventor LOPES, JOHN ALEX
Owner LOPES JOHN ALEX
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