Colloidal suspension of submicronic particles as vectors for active principles and method for preparing same

Abstract

A suspension of vector particles (PV) based on polyamino acids and have a mean hydrodynamic diameter between 30 and 120 nm, and an insulin load factor of from 5 to 25% of associated insulin volume relative to the polyamino acid volume forming the vector particles. The polyamino acids are double-block polymers containing hydrophilic and hydrophobic monomers. The suspension may be prepared by copolymerizing N-carboxy anhydrides of hydrophobic monomers and precursors of hydrophilic monomers, in the presence of N-methyl pyrrolidone and methanol. The copolymer is optionally neutralized, subjected to dialysis, concentrated and water is eliminated to produce a solid powder, which can be suspended in a liquid to produce the colloidal suspension. Active principles such as insulin or vaccines are associated with the carrier particles to prepare special pharmaceutical products.

Description

TECHNICAL FIELD

[0001] The field of the present invention is that of Vector Particles (PV), which are useful for the administration of active principles (PA). The latter are preferably medicaments or nutrients for administration to an animal or human organism by the oral, nasal, vaginal, ocular, subcutaneous, intravenous, intramuscular, intradermal, intraperitoneal, intracerebral or parenteral route, or the like. However, this may also involve cosmetic products or plant-production products, such as herbicides, pesticides, insecticides or fungicides, or the like. In terms of chemical nature, the PAs most particularly, but without limitation, involved in the invention are, for example, proteins, glycoproteins, peptides, polysaccharides, lipopolysaccharides, oligonucleotides, polynuclides and organic molecules.

[0002] The present invention relates, more precisely, to colloidal suspensions of Vector Particles, advantageously of the submicronic type, based on polyamino acids (PAA). The p...

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