Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Dietetic composition

a technology of composition and dietetics, applied in the field of dietetic composition, can solve the problems that the amount of above dietetic substances is not sufficient to achieve a dietary effect, and achieve the effects of promoting the degradation of neutral fat, reducing liver triglyceride, and enhancing lipase activity

Inactive Publication Date: 2009-11-05
ORIZA YUKA KK
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]This invention provides a highly safe dietetic composition, fat absorption suppressive composition, pancreatic lipase activity inhibiting composition, carnitine palmitoyltransferase activity promoting composition and cl-glucosidase activity inhibiting composition derived from green coffee beans.
[0015]In this invention (Invention 1), an excellent and highly-safe diet-promoting composition can be derived from green coffee beans, and the effect on the above programs (1) to (4) can be entirely obtained in a balanced manner. Thus, the weight gain by taking fat into the body can be prevented, and the effective diet can be done.
[0016]Referring now to the aforementioned Publications 1 and 2, a medicine for improving lipid metabolism focused on a function of chlorogenic acid contained in the coffee beans is disclosed in Publication 1 and another different medicine for preventing and improving lifestyle-related diseases is disclosed in Publication 2. And it is disclosed in common that an extract derived from green coffee beans contains an anti-obesity effect.
[0017]However, a dietetic composition in the present invention is a highly-concentrated bioactive composition containing chlorogenic acid derived from green coffee beans after extracting “defatted green coffee beans” with the solar solvent, and is different from the composition obtained simply by extracting the green coffee beans. And, the polar solvent extract derived from the defatted green coffee beans contains plenty of excellent diet-promoting composition as well as chrologenic acid. Therefore, compared to the extract derived from non-defatted green coffee beans, a good effect of diet (weight-reducing effect) can be expected in the present invention. (See Groups 3 and 4 in Chart 9, Example 5 of the Publication 1). In the polar solvent extract derived from the green coffee beans in the present invention, such an excellent weigh-reducing effect can be more expected than in other cases which are done by simply taking the chlorogenic acid into the body. Such an excellent effect is a unique effect which can not be predicted in the Publications 1, 2 and others.(Inventions 2 and 3)
[0028]As described above, when determining the diet effect focusing on fat, normally one of the following effects on the fat metabolism pathway is reviewed; (1) suppression of fat absorption, (2) inhibition of fat accumulation (3) enhancement of lipolysis, and (4) enhancement of fat burning. The aforementioned Publications 1 and 2 teach the lipolysis promoting effect indicated by measuring the amount of triglycerol, and also suggests an anti-obesity effect contained in the green coffee beans. However, it is little known that the extract derived from the green coffee beans has a fat absorption suppressive effect when the fat is taken into the body.
[0045]In the test of the bioactivity of glycolytic enzyme, such as α-amylase, α-glucosidase or the like, derived from the green coffee beans, it was found that the extract derived from the green coffee beans has an excellent inhibitory effect especially in regard to the α-glucosidase. Thus, in this invention (Invention 5), α-glucosidase enzyme activity is inhibited so that postprandial elevation of blood glucose levels can be suppressed and the diabetes and obesity can be finally prevented. In other words, this invention provides an anti-diabetic composition or dietetic composition containing an extract derived from the green coffee beans, as an active substance for inhibiting α-glucosidase activity. And as an active substance for inhibiting α-glucosidase activity, the polar solvent extract (including ethanol extract and N-hexane defatted substance) which is derived from the defatted green coffee beans described in the above Invention 5 can be used for the active substances for effects.

Problems solved by technology

Obesity is caused by excessive eating, insufficient exercise or the like, and is considered as a risk factor for lifestyle-related diseases typically seen in diabetic persons.
However, some of the above dietetic substances are not sufficient to achieve a dietary effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dietetic composition
  • Dietetic composition
  • Dietetic composition

Examples

Experimental program
Comparison scheme
Effect test

examples

[0109]The examples in this invention are herein described. The descriptions indicated below are only the explanations to determine the diet effect or the like on the inventive dietetic composition. They are not limited to the products and method for manufacturing the products.

(Method for Manufacturing the Dietetic Composition)

[0110]Indonesia's robusta green coffee beans are used as an ingredient. Firstly, compress the green coffee beans to reduce the oil, then obtain one kilogram of the compressed coffee beans. Secondly, crush all the compressed coffee beans, reflux them with hexane, and remove the remaining oil from them. Thirdly, extract the defatted coffee beans with the hydroethanol having the ethanol concentration of 60 wt % and dry the ethanol extract so that 60 grams of the green coffee bean extract (example: dietetic composition) can be obtained. Also, HPLC (high-performance liquid chromatography) of the ingredient of the green coffee bean extract detected approx. 45 wt % of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

(Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt / wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

Description

FIELD OF THE INVENTION[0001]This invention relates to a dietetic composition derived from green coffee beans and is applicable for ingredients of food and drink, medicines, cosmetics, or the like.[0002]Obesity is caused by excessive eating, insufficient exercise or the like, and is considered as a risk factor for lifestyle-related diseases typically seen in diabetic persons. The total number of diabetic patients and people standing a good chance of developing diabetes is increasing yearly.[0003]As dietetic substances, capsaicin to enhance fat metabolism, chitosan to reduce fat absorption, citrus aurantium to enhance lipolysis and others are already known. The above dietetic substances are now used for food or the like to support slimming for the purpose of beautification such as cellulite reduction, excess body water extraction, body fat reduction or the like. However, some of the above dietetic substances are not sufficient to achieve a dietary effect. Therefore, high-value added d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/74A61P3/04A23F5/02A23L33/20A61K8/97A61K36/00A61P43/00A61Q19/00A61Q19/06A61Q90/00
CPCA23F5/02A61K8/97A61Q19/06A61Q19/00A61K36/74A61K8/9789A61P3/04A61P43/00
Inventor SHIMODA, HIROSHIAITANI, MICHIOSUGISHITA, TOMOKOOKADA, TADASHIMURAI, HIROMICHIYAMADA, EMI
Owner ORIZA YUKA KK
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products