Non-regular electrical stimulation patterns for treating neurological disorders

Active Publication Date: 2010-06-17
DUKE UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0012]Previous efforts (see Feng et al. 2007) sought to design stimulation trains that minimized the total current injection. The systems and methodologies disclosed herein include an objective function that maximizes therapeutic benefit (by minimizing the error function) and improves stimulation efficiency (by reducing the stimulation frequency), using a model of the STN that reproduces the fre

Problems solved by technology

Although effective, conventional high frequency stimulation generates stronger side-effects than low frequency stimulation, and the therapeutic window between the voltage that generates the desired clinical effect(s) and the voltage that generates undesired side effects decreases with increasing frequency.
Further, high stimulation frequencies increase po

Method used

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  • Non-regular electrical stimulation patterns for treating neurological disorders
  • Non-regular electrical stimulation patterns for treating neurological disorders
  • Non-regular electrical stimulation patterns for treating neurological disorders

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[0039]Computational models of thalamic DBS (McIntyre et al. 2004, Birdno, 2009) and subthalamic DBS (Rubin and Terman, 2004) can be used with genetic-algorithm-based optimization (Davis, 1991) (GA) to design non-regular stimulation patterns or trains that produce desired relief of symptoms with a lower average stimulation frequency than regular, high-rate stimulation. McIntyre et al. 2004, Birdno, 2009; Rubin and Terman, 2004; and Davis, 1991 are incorporated herein by reference.

[0040]In the GA implementation, the stimulus train (pattern) is the chromosome of the organism, and each gene in the chromosome is the IPI between two successive pulses in the train. The implementation can start, e.g., with trains of 21 pulses (20 genes) yielding a train length of ˜400 ms (at average frequency of 50 Hz), and the 6 s trains required for stimulation are built by serial concatenation of 15 identical pulse trains. The process can start with an initial population of, e.g., 50 organisms, co...

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Abstract

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

Description

RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61 / 102,575, filed Oct. 3, 2008; and entitled “Stimulation Patterns For Treating Neurological Disorders Via Deep Brain Stimulation,” which is incorporated herein by reference.FIELD OF THE INVENTION[0002]This invention relates to systems and methods for stimulating nerves in animals, including humans.BACKGROUND OF THE INVENTION[0003]Deep Brain Stimulation (DBS) has been found to be successful in treating a variety of brain-controlled disorders, including movement disorders. Generally, such treatment involves placement of a DBS type lead into a targeted region of the brain through a burr hole drilled in the patient's skull, and the application of appropriate stimulation through the lead to the targeted region.[0004]Presently, in DBS, beneficial (symptom-relieving) effects are observed primarily at high stimulation frequencies above 100 Hz that are delivered in stimulation patter...

Claims

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Application Information

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IPC IPC(8): A61N1/05
CPCA61N1/36082A61N1/36178A61N1/36196A61N1/36A61N1/0534A61N1/37235A61N1/36064A61N1/36071A61N1/36096A61N1/3615A61N1/36171A61N1/36067
Inventor GRILL, WARREN M.DORVAL, II, ALAN D.
Owner DUKE UNIV
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