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Composition for amelioration of hypoalbuminemia

a technology of hypoalbuminemia and composition, which is applied in the field of composition for enhancing hypoalbuminemia, can solve the problems of reducing compliance, nausea, diarrhea, and reducing the effect of albumin production, and achieving the effects of reducing side effects, reducing side effects, and high safety

Inactive Publication Date: 2013-03-07
OTSUKA PHARM FAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a composition that can improve low albumin levels in the blood. This composition contains a specific amino acid called branched-chain amino acid, which is effective without containing a lot of valine. This composition is safe and effective in treating various causes of low albumin levels, such as malnutrition, surgery, hepatic disease, leakage of in vivo proteins, and many others. The composition can also reduce symptoms associated with low albumin levels, such as leg cramps, lung edema, and ascites fluid.

Problems solved by technology

Such conventional amino-acid preparations containing all of the three branched-chain amino acids have not yet satisfied requirement of clinical practice for the hypoalbuminemia amelioration effect on a hepatic disease patient.
Furthermore, conventional amino-acid preparations containing all of the three branched-chain amino acids may develop side effects such as nausea, a feeling of fullness in the abdomen, diarrhea, constipation, abdominal discomfort, abdominal pain, vomiting, inappetence and heartburn.
These side effects are due to a heavy protein load in the body.
Therefore, a conventional amino-acid preparations containing a large amount of protein may reduce compliance.
However, the above conventional amino-acid preparation and the composition disclosed in Japanese Patent No. 3712539 cannot sufficiently exert an efficacy that an amino-acid preparation is expected to have, particularly, an albumin production promotive effect.

Method used

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  • Composition for amelioration of hypoalbuminemia

Examples

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examples

[0045]Now, the present invention will be more specifically described based on Examples; however, the present invention is not restrictively interpreted based on the description of these Examples.

[0046]In this test, human primary cultured hepatocytes were cultured by each test solution to check a change of albumin mRNA expressional potency and a change of secretion level of albumin. The test was performed as follows.

[0047](1) Albumin mRNA and Hypoxanthine Phosphoribosyltransferase 1 (Hereinafter Referred to Simply as “HPRT1”) mRNA

[0048]Albumin mRNA and HPRT1 mRNA were measured. The nucleotide sequences of albumin and HPRT1 are registered in the GenBank as follows and each nucleotide sequence follows the sequence registered.

[0049]Albumin; GenBank accession number XM 031322

[0050]HPRT1; GenBank accession number NM 000194

[0051]Note that, HPRT1, which is a house keeping gene serving as a control, was measured in the same test. The sequences of primers and probes used in measurement of alb...

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Abstract

The present invention is directed to a composition for ameliorating hypoalbuminemia containing a branched-chain amino acid(s) as an active ingredient(s), wherein the composition contains leucine and / or isoleucine as the active ingredient(s) and does not contain valine. As the above branched-chain amino acid(s), leucine and isoleucine are preferably contained. The mass ratio of leucine to isoleucine described above is preferably from 0.1 to 10. As the above branched-chain amino acid(s), either leucine or isoleucine alone may be contained. The present invention is suitably used as an infusion formulation, an oral formulation or a food or drink.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition for ameliorating hypoalbuminemia, and particularly relates to a composition for ameliorating hypoalbuminemia for preferred use in forms such as an infusion formulation, an oral formulation and a food or drink.BACKGROUND ART[0002]Conventionally, amino-acid preparations containing a branched-chain amino acids have been widely used for the purpose of ameliorating hypoalbuminemia and the like caused by a hepatic disease, etc. Such amino-acid preparations for ameliorating hypoalbuminemia containing a branched-chain amino acids are required to have an albumin production promotive effect as an efficacy index and reductions of side effects as a safety index. Three amino acids, valine, leucine and isoleucine are branched-chain amino acids. For example, Livact (registered trade mark) is an example of amino-acid preparations containing all of these valine, leucine and isoleucine as active ingredients, and is widely used.[0003]...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/198A61P7/06C07C229/08
CPCA23L1/3051A61K31/198A23L2/52A23L33/175A61P3/00A61P7/00A61P7/06A61P43/00A23V2002/00A23V2200/30
Inventor DOI, MASAKONISHIMURA, MASUHIROTAMURA, NOZOMI
Owner OTSUKA PHARM FAB INC
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