Synergistic biomolecule-polymer conjugates

a biomolecule and polymer technology, applied in the field of synergistic biomolecule polymer conjugates, can solve the problems of reducing the bioactivity of the parent protein and organic therapeutic molecules, reducing the biological activity of the proteins that are pegylated by conventional permanent branched or linear peg compounds, etc., to achieve the effect of exacerbate systemic toxicity
US20130195799A1Inactive Publication Date: 2013-08-01PEG BIOSCI
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
PEG BIOSCI
Publication Date
2013-08-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The synergistic biomolecule-polymer conjugates are the long-acting, in vivo controlled continuous-release and hybrid synergy systems of biomolecules that provide increased biological activities and enhanced pharmacological properties for achieving greater therapeutic efficacies.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to the novel synergistic biomolecule-polymer conjugates produced from the attachment of the permanent-cleavable-linkages or all-cleavable-linkages polymers to biologically active molecules to provide synergistically enhanced biological activities in vivo and improved pharmacokinetic (PK) and pharmacodynamic (PD) properties of delivered biomolecules for achieving optimum therapeutic efficacies. The synergistic biomolecule-polymer conjugates integrate the advantages of PK and PD properties of large and small biomolecule-polymer conjugates in vivo. The present invention further relates to the novel synergistic Interferon-α-polymer (Synergy-IFN-α-polymer) conjugates, which are the in vivo enzyme-controlled, continuous-release and hybrid synergy systems of interferon that provide the increased biological activity and enhanced pharmacological properties for achieving greater interferon-α related therapies.BACKGROUND OF THE INVENTIO...

Claims

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