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62results about How to "Increase activity level" patented technology

FX activity in cells in cancer, inflammatory responses and diseases and in autoimmunity

InactiveUS20030129190A1Reduced activityInhibiting and preventing adherenceGenetic material ingredientsAntibody ingredientsDiseaseCancer cell
A method is provided for inhibiting or preventing adherence of cancer cells or immunocytes to their target cells or target tissues by reducing the level of activity of FX enzyme in the cells. The reduction may either be in the amount of the FX protein or in the enzymatic activity of the protein in the cells. In addition, methods and agents are provided for down-regulating or up-regulating the level of activity of FX in cancer cells and in immunocytes. The down-regulation of FX in cancer cells is provided for inhibiting or preventing metastasis of cancer cells and the up-regulation of FX activity in cancer cells is useful for increasing the immunogenicity of these cells when used in a cancer vaccine. Down-regulation of FX in immunocytes inhibits or prevents conditions such as undesired inflammatory responses, auto-immunity and transplant rejection. Up-regulation of FX activity in immunocytes is useful for enhancing an immune reaction in cases of reduced immunity of an individual. The regulation of the level of activity of FX in cancer cells and immunocytes may be achieved by contacting the cells with various agents such as antibodies, growth factors, cytokines or various combinations of such agents. The level of activity of FX in cancer cells is also used as a diagnostic and prognostic factor of metastasis and the level of activity of FX in immunocytes is used as a marker of activation useful in determining an individual's response to an immunogen.
Owner:RAMOT UNIV AUTHORITY FOR APPLIED RES & INDAL DEVMENT

Multifunctional orthotic plate device for legs, feet and ankle joints of hemiplegic patient

The invention provides a multifunctional orthotic plate device for the legs, feet and ankle joints of a hemiplegic patient. The device comprises a bottom plate, a spring reset device, a pedal plate, apositioning frame, a sliding groove, an angle adjustment frame structure, a detachable message wheel structure, an auxiliary rod structure, an auxiliary holding tube structure, an antiskid cushion block and a protective strip, wherein the spring reset device is arranged in the middles of the inner sides of the bottom plate and pedal plate through bolts. The multifunctional orthotic plate device for the legs, the feet and the ankle joints of the hemiplegic patient has the advantages that an auxiliary operating rod is arranged on the upper left portion of an adjustable control rod, thereby being conductive to reducing a gap between a user and a handle when the user is located at the left side, and providing convenience for utilizing the auxiliary operating rod to control the angle of the adjustable control rod; a hook-and-loop fastener mother buckle is attached to a hook-and-loop fastener son buckle, thereby being conductive to fixing a massage lantern ring at the outer side of a rotating roller conveniently, and cooperating with a massage ball to massage the leg of the patient conveniently; and rest springs are arranged at the inner sides of an upper side mounting plate and lower side mounting plate through fixing bolts respectively, thereby being conductive to providing convenience for resetting the pedal plate.
Owner:TIANJIN CITY THIRD CENT HOSPITAL
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