The invention mainly relates to the field of textile processing technology, and discloses a high-strength flame-retardant leather sewing thread, which comprises the following raw materials, by weight:33-35 parts of aramid, 21-23 parts of bamboo fiber, 21-23 parts of cotton fiber, 16-18 parts of ceramic fiber, 12-14 parts of polyacrylonitrile-based carbon fiber; the high-strength flame-retardant leather sewing thread has high strength, high tightness and strong stability, and can effectively inhibit combustion with flame retardant grade reaching V-1 level, and can improve the strength and grade of leather products; blending bamboo fiber and cotton fiber into core yarn can improve the strength and anti-bacterial property of sewing thread, inhibit the production of mould, avoid mouldy sewingthread after long-term use, and prolong the service life of leather products. The core yarn is soaked in sodium selenite solution after completion, and the shrinkage ratio of core yarns is reduced toless than 0.5%, and the sewing fastness of leather products is increased and the health care and bacteriostasis function of sewing thread is improved.