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Composition for trapping and inactivating pathogenic microbes and spermatozoa and its pharmaceutical uses

A composition, technology of antimicrobial agent, applied in the field of compositions for capturing and inactivating pathogenic microorganisms and sperm and its pharmaceutical use, can solve the problems of less likely to be used, difficult to use, reduced sexual pleasure and sensitivity, etc.

Inactive Publication Date: 2009-05-20
RUSH UNIV MEDICAL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the use of such devices is likely to reduce sexual pleasure and sensitivity
Therefore, these devices are unlikely to be used on a permanent basis due to the difficulty of use, especially during "spurious" sexual activity

Method used

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  • Composition for trapping and inactivating pathogenic microbes and spermatozoa and its pharmaceutical uses
  • Composition for trapping and inactivating pathogenic microbes and spermatozoa and its pharmaceutical uses
  • Composition for trapping and inactivating pathogenic microbes and spermatozoa and its pharmaceutical uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Gels were prepared using several methods with the following general recipe.

[0045] Element quantity(%) Alginic acid 4.25 xanthan gum 3.0 glycerin 8.0 lactic acid 2.0

[0046] citric acid 1.0 Potassium hydrogen tartrate 0.4 benzoic acid 0.2 Nonoxynol-9 0-10.0 distilled water balance

[0047] Gels containing varying levels of nonoxynol-9 (ie, about 0-10%) were prepared. The pH of the formulation was adjusted to pH about 3.5-3.6 with sodium hydroxide. Use this formulation to obtain high-quality capture gels. Additionally, unlike the formulation of Example 2, these formulations showed good stability over time even at levels of nonoxynol-9 up to about 5%.

[0048] As noted above, capture gels of the invention are generally prepared using conventional gel preparation techniques. It is however important to ensure that the buffer is completely soluble in the final product and air entrainment is...

Embodiment 2

[0056] Example 2. Preparation of additional gels using hydroxyethyl cellulose as the second bioadhesive agent. The following general formulations were prepared:

[0057] Element quantity(%) Alginic acid 3.5 xanthan gum 2.0 Hydroxyethyl cellulose 1.75 glycerin 10.0 lactic acid 2.0 citric acid 1.0 Potassium hydrogen tartrate 0.4 benzoic acid 0.2 Nonoxynol-9 0-10.0 distilled water balance

[0058] The gel was prepared in the same general manner as in Example 1, except that the hydroxyethyl cellulose was mixed with the glycerin and xanthan gum mixture.

[0059] Capture gels containing varying levels of nonoxynol-9 (ie, about 0-10.0%) were prepared. The pH of the formulation was adjusted to about 3.5-3.6 with sodium hydroxide. However, formulations prepared with typical levels of nonoxynol-9 (ie, greater than about 5%) were not as stable as desired. Stability studies indicated that these nonoxynol-9 form...

Embodiment 3

[0060] Example 3. This example illustrates the acid buffering capacity of the gels of the invention. (In addition, and in more detail, a study on the acid buffering capacity of the gels of the present invention is included in Example 10 below). Using the gel prepared in Example 1, the pH of the gel before and after mixing with different amounts of semen was determined. Semen samples were collected from healthy human volunteers and screened for sperm count, motility, pH and volume; the initial pH of semen was about 7.9. The gel is diluted with saline and mixed with semen at the desired gel to semen ratio. The following results were obtained:

[0061] Dilution of gel with saline pH after mixing with semen 1:5 3.97 1:10 4.49 1:20 5.66

[0062] A 1:5 dilution represents approximately 1 part gel to approximately 1 part semen; a 1:10 dilution represents approximately 1 part gel to approximately 2 parts semen. Since the average ejaculate volume is e...

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Abstract

Antimicrobial and contraceptive compositions and methods which prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and / or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions forms a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

Description

[0001] related application [0002] This application is based upon and claims the benefit of US Provisional Application Serial No. 60 / 187,574, filed March 7,2000. field of invention [0003] The present invention generally relates to compositions and methods for preventing the transmission of sexually transmitted diseases (STDs), and / or reducing the rate of transmission of these STDs in sexually active individuals. The present invention also generally relates to compositions and methods for preventing conception and / or reducing the risk of conception in sexually active females. While not wishing to be bound by theory, it is believed that the compositions of the present invention, when applied intravaginally during sexual intercourse, will physically capture and inactivate STD-related pathogens contained in ejaculated semen that may remain in the vagina Sexual microbes and sperm. The composition and method are particularly effective in preventing or reducing the possibility o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/717A61K31/722A61K31/723A61K31/734A61K31/75A61K9/00A61K9/06A61P15/18A61P31/18A61P43/00A61K31/00A61K31/085A61K31/14A61K31/192A61K31/7048A61K31/795A61K47/10A61K47/12A61K47/18A61K47/36
CPCA61K31/00A61K31/192A61K31/795A61K47/12A61K31/14A61K31/7048A61K47/10A61K31/085A61K9/0034A61K47/36A61K47/183A61P15/18A61P31/00A61P31/18
Inventor S·加格L·J·D·赞费德R·A·小安德森D·P·沃勒
Owner RUSH UNIV MEDICAL CENT
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