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Double cladding water-based magnetofluid and method for producing the same

A ferrofluid and double-coating technology, which is applied in the field of nanotechnology and biomedicine, can solve the problems of poor coating effect and weak magnetism, and achieve good magnetic response, small particle size and good monodispersity. Effect

Inactive Publication Date: 2009-12-23
JIAYING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are some deficiencies in the prior art. One, in the synthesis technology of magnetic nanoparticles, most of them are difficult to synthesize magnetic nanoparticles that fully meet the size requirements. For example, CN1702782A uses centrifugation to remove unstable particles. From the patent application According to the transmission electron microscope photo, the bonding phenomenon of the particles is obvious, indicating that the control conditions of the synthesis reaction and the effect of coating with polymer materials are not good; the second is that the magnetism is weak, for example, the saturation magnetization of the water-based magnetic fluid provided by CN1702782A is only 1.6 ~2.5emu / g, the saturation magnetization of water-based magnetic fluid prepared in all examples is less than 1.0emu / g

Method used

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  • Double cladding water-based magnetofluid and method for producing the same
  • Double cladding water-based magnetofluid and method for producing the same

Examples

Experimental program
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Effect test

Embodiment 1

[0018] (1) Weigh 27.029g FeCl 3 ·6H 2 Add O into boiled double distilled water, stir to dissolve, cool to room temperature, drop 3~5mL dilute hydrochloric acid, and then add 11.361g FeCl 2 4H 2 O, stir to dissolve, the total volume of the mixed solution is 1000mL, Fe in the mixed solution 3+ and Fe 2+ The ratio of the amount of substances is 1.75;

[0019] (2) Preheat the mixed solution in the reactor and stir to make it fully mixed, measure 85.0mL of 25% NH 3 ·H 2 O poured into the reactor, NH 3 ·H 2 The addition of O can also be added dropwise or poured in several times, the stirring speed is gradually increased from 1000r / min to 2500r / min, the temperature is controlled at 35°C, the pH value of the solution is 10, and the constant temperature reaction is 60min to obtain nano-Fe 3 o 4 particles;

[0020] (3) Weigh 0.06g medicinal agar and put it into 6mL distilled water, heat it at 90°C to dissolve it, pour it into step (2), gradually increase the stirring speed fro...

Embodiment 2

[0025] (1) Weigh 108.116g FeCl 3·6H 2 O was added to boiling double distilled water, stirred to dissolve, after cooling to room temperature, 3~5mL HCl was added dropwise, and then 45.444g FeCl was added 2 4H 2 O, stir to dissolve, the total volume of the mixed solution is 1000mL, Fe in the mixed solution 3+ and Fe 2+ The ratio of the amount of substances is 1.75;

[0026] (2) Preheat the mixed solution in a reactor and stir to make it fully mixed, take 325mL concentration of 25% NH 3 ·H 2 O was poured into the reactor, the stirring speed was gradually increased from 1000r / min to 3000r / min, the temperature was 35°C, the pH value of the solution was 10, and the reaction was carried out at constant temperature for 60min. get nano Fe 3 o 4 particles;

[0027] (3) Weigh 0.24g medicinal agar and put it into 24mL distilled water, heat it at 90°C to dissolve it, pour it into step (2), gradually increase the stirring speed from 1000r / min to 2500r / min, the temperature is 55°C, ...

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Abstract

The invention relates to a double-coated water-based magnetic fluid and a preparation method thereof. The magnetic fluid includes water, nano-Fe3O4 particles and a dispersant, and is characterized in that the particle size of the nano-Fe3O4 particles is 1-16nm, and the surface-coated dispersant of the nano-Fe3O4 particles is The agent is medicinal agar and polyethylene glycol, and the particle size of the composite particles obtained by coating the surface of nano-Fe3O4 particles with medicinal agar and polyethylene glycol is less than 45nm; choosing medicinal agar and polyethylene glycol as the dispersant, nano-Fe3O4 particles The synthesis and surface modification of double-coated water-based magnetic fluids are prepared step by step. The surface has functional groups: active groups such as carboxyl and hydroxyl groups, which make the double-coated water-based magnetic fluids have good magnetic responsiveness and biological Affinity, biodegradability and suspension stability, the saturation magnetization of the magnetic fluid is 1.0-10.0emu / g, and it is used in biomedical fields such as drug carriers for special treatment and diagnosis.

Description

technical field [0001] The invention belongs to the field of nano science technology and biomedicine, and relates to a double-coated water-based magnetic fluid and a preparation method thereof. Background technique [0002] The so-called magnetic fluid, also known as magnetic liquid, is a colloid system formed by highly dispersing magnetic nanoparticles adsorbed with surfactants in a carrier liquid. It has both the superparamagnetism of nano-solid materials and the fluidity of liquids. It is a new type of The liquid functional nanomaterials have been widely used in the fields of sealing, lubrication, damping, grinding, separation, printing and printing, and environmental protection. In recent years, ferrofluid has been extended to cell separation, tumor hyperthermia, nuclear magnetic resonance imaging and targeted agents in the field of biomedicine. [0003] Due to the non-biocompatibility of non-water-based magnetic fluids, water-based magnetic fluids are mainly used in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/44H01F1/10C04B35/26C04B35/622
Inventor 苑星海
Owner JIAYING UNIV