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Production of gamma immune protein capsules

An immunoglobulin and capsule technology, which is applied in the directions of capsule delivery, antiviral agents, and drug combination, can solve the problems of large consumption of organic solvents and chemical reagents, lengthy preparation of immunoglobulins, inconvenient recovery of purified organic solvents, etc. Avoid dust flying, facilitate mechanized or automated production, and be suitable for continuous large-scale production

Inactive Publication Date: 2010-01-27
程国根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all consume a large amount of organic solvents and chemical reagents, and all require a series of lengthy preparation processes to obtain immunoglobulin
The above method is complex in process, high in cost, time-consuming, and brings a lot of inconvenience to the purification of the product and the recovery of the organic solvent.

Method used

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  • Production of gamma immune protein capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Source and collection of blood:

[0028] Fresh pig blood or goose blood produced by fixed-point slaughter (all slaughtered pigs have passed strict quarantine inspection).

[0029] The animal blood is firstly collected by vacuum and then flowed through pipelines into a closed and constant temperature container (with anticoagulant added in advance) for inspection. The blood and dirty blood are discarded, and then transported to the separation workshop through a refrigerated device.

[0030] (2) Separation:

[0031] The blood is input into the continuous separator through the pipeline, and the serum is separated and collected in the storage tank.

[0032] (3) Dehydration:

[0033] The serum stored in the storage tank is fed into a hollow fiber ultrafiltration device with a molecular weight of 100,000 through a peristaltic pump to filter out 20% of the water in the plasma.

[0034] (4) Salting out:

[0035] Put the above water-filtered serum into a stainless steel r...

Embodiment 2

[0045] Technical process (1)-(8) is the same as embodiment 1, except that steps (6) and (7) adopt the following material proportioning, the material proportioning of all the other steps is the same as embodiment 1.

[0046] Step (6) adds stabilizer:

[0047] Then in the above ultrafiltrate by 0.1% by weight of the filtrate, add a polysaccharide mixture with a weight ratio of 1: 15 and gelatin to mix as a stabilizer, wherein the polysaccharide mixture is sucrose, maltose, lentinan, astragalus polysaccharide in a weight ratio of 1: 05 : 0.2: 0.1 uniformly mixed. To ensure that the product is not damaged during the drying process, the activity can reach more than 80%.

[0048] Step (8) disinfection and sterilization:

[0049] Gamma immunoglobulin, lentinan and astragalus polysaccharide are uniformly mixed in a ratio of 1:0.2:0.4 by weight, irradiated with gamma ray to make it reach the hygienic standard, and then made into capsules.

Embodiment 3

[0051] Technical process (1)-(8) is the same as embodiment 1, except that steps (6) and (7) adopt the following material proportioning, the material proportioning of all the other steps is the same as embodiment 1.

[0052] Step (6) adds stabilizer:

[0053] Then in the above ultrafiltrate by 0.5% by weight of the filtrate, add a polysaccharide mixture with a weight ratio of 1: 3 and mix it with gelatin as a stabilizer, wherein the polysaccharide mixture is sucrose, maltose, lentinan, and astragalus polysaccharide in a weight ratio of 1: 1.5 : 1: 0.5 evenly mixed. To ensure that the product is not damaged during the drying process, the activity can reach more than 80%.

[0054] Step (8) disinfection and sterilization:

[0055] Gamma immunoglobulin, lentinan and astragalus polysaccharide are uniformly mixed in a ratio of 1:0.6:0.8 in parts by weight, irradiated with gamma ray to make it reach the hygienic standard, and then made into capsules.

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Abstract

A process for preparing the capsules of immunoglobulin C includes such steps as collecting the blood of animal, filtering, disinfecting, separating, concentrating, salting out, ultrafiltering, proportionally mixing it whit polyose mixture and gelatin as stabilizer, low-temp spray drying, and proportionally mixing it with lentinan and astragalus polyose. Said capsule can be used for improving immunity, regulating the function of immune system, and preventing the epidemic disease and the disease of digestive tract.

Description

technical field [0001] The invention relates to a preparation method of gamma immunoglobulin capsules, in particular to a preparation method of gamma immunoglobulin capsules extracted from animal blood, and belongs to the field of biological health care products. Background technique [0002] Immunoglobulin is a kind of globular protein with immune function produced by plasma cells after the human and animal body is stimulated by antigen. It is a general term for antibody proteins that directly participate in immune response. Various immunoglobulins can specifically combine with corresponding antigens to form antigen-antibody complexes (immune complexes), thereby blocking the harmful effects of antigens on humans and animals, and the killing of antigens such as bacteria is finally completed by complement. [0003] Immunoglobulins with antibody properties, the preparations of which are widely used in medicine. In the veterinary field, the application of globulin preparations...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K9/48A61P31/12A61P43/00
Inventor 陈来同张朝贵
Owner 程国根