Absorbale magnesium alloy stent possessing double controllable relieasing coating layer and its preparation method

A magnesium alloy stent, magnesium alloy technology, applied in stents, coatings, medical science and other directions, can solve the problems of fast degradation speed and no drug-loaded coating, and achieve the effect of avoiding coating peeling off

Inactive Publication Date: 2007-07-18
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the stent degrades too quickly in

Method used

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  • Absorbale magnesium alloy stent possessing double controllable relieasing coating layer and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Magnesium alloy WE43 was engraved into a stent with a laser, and then placed in a 2 Ultrasonic treatment in the pickling solution for 30 minutes, then put it in a vacuum furnace for annealing treatment, raise the temperature to 1100°C at a rate of 3°C / min, keep it for 30 minutes, and then lower it to 20°C at a rate of 4°C / min °C, then use an ultrasonic cleaner with a power of 500W to ultrasonically clean in deionized water for 15 minutes and then dry.

[0019] An anti-corrosion coating is prepared on the dried scaffold base. The method of micro-arc oxidation is adopted, and the electrolyte composition is NaOH20g / L, NaAlO 2 15g / L, H 2 o 2 5g / L. The oxidation time is 40 minutes, and the current density is 0.20A / cm 2 . Afterwards, the stent with the anticorrosion coating was placed in deionized water for ultrasonic cleaning for 30 minutes, and dried at room temperature to obtain the stent with the anticorrosion coating of aluminum.

[0020] Dissolve 1g of chitosan i...

Embodiment 2

[0025] The experimental conditions and operation process of Example 2 are the same as those of Example 1, except for a change: in the process of preparing the cross-linked dense drug-loaded coating, chitosan is changed to collagen.

[0026] The prepared scaffold was tested in artificial simulated body fluid at 37° C., and the result showed that the release percentage of rapamycin was 51.5% in 20 days, and the release period could reach 50 days. The polymer coating degrades within 180-190 days, and the metal stent degrades within 340-350 days.

Embodiment 3

[0028] The experimental conditions and operation process of Example 3 are the same as those of Example 1, except that in the process of preparing the non-crosslinked drug-loaded coating, poly-L-lactic acid was changed to polyglycolic acid.

[0029] The prepared scaffold was tested in artificial simulated body fluid at 37° C., and the results showed that the release percentage of rapamycin was 45.5% at 20 days, and the release period could reach 55 days. The polymer coating degraded within 185-190 days, and the metal stent degraded within 340-350 days.

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Abstract

An absorbabal Mg-alloy scaffold with double release-controllable coated layers is composed of a skeleton made of the Mg alloy WE43 containing Mg and one or more of Y, Nd, Zr, Yb, Er, Dy and Gd, a compact anticorrosive layer on the surface of skeleton and made of magnesium aluminum oxide or cerium oxide, a cross-linked compact madicine carrying layer on said anticorrosive layer and made of chitosan or collagen, a non-cross-linked medicine carrying layer on the first one and made of polylevolactic acid or polyhydroxyacetic acid, and a surficial release-controlling layer made of polylevelactic acid or polyhydroxyacetic acid. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an absorbable magnesium alloy stent with a double controllable release coating and a preparation method thereof, belonging to the technology of drug eluting stents. Background technique [0002] In 1964, Dotter (Dotter CT, Judkins MD. Transluminal treatment of arterioscleroticobastruction: a new technique and a preliminary report of its application [J]. Circulation, 1964, 30: 654) proposed the concept of percutaneous transluminal angioplasty, and It is proposed to use silicone rubber or plastic to support the blood vessel in order to keep the blood flow in the blood vessel open. In 1986, Sigwart (Sigwart U, Puel J, Mirkovitch V, et al. Intravascular stents to prevent occlusion and restenosis after transluminalgrafting [J]. Radiology, 1986, 160: 723) successfully implemented the first coronary stent operation, and then , the technology has developed rapidly and has become the most important method of interventional treatment of...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/10A61F2/82
Inventor 许鑫华张春怀逯平
Owner TIANJIN UNIV
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