Traditional Chinese medicine Ningxintong preparation for treating unstable angina in the coronary heart disease and preparation method thereof
A technology for instability and angina pectoris, applied in the field of traditional Chinese medicine preparations for the treatment of unstable angina pectoris of coronary heart disease and the preparation of the preparations, can solve the problems of poor repeatability, retention, lack of dosage form reform, etc.
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Embodiment 1
[0032] Embodiment 1. Ningxintong preparation (granule) is made of the crude drug of following weight ratio
[0033] [Prescription] Astragalus 10g Asarum 6g
[0034] Chuanxiong 10g Pueraria 8g
[0035] Holly hair 8g
[0036] [preparation method]
[0037] 1. Take the prescription amount of Rhizoma Chuanxiong and Asarum plus 6 times of water, soak for 1 hour, refer to the "Chinese Pharmacopoeia" 2000 edition 1 appendix volatile oil determination method to extract volatile oil for 6 hours, release the oil layer and medicinal residue after cooling;
[0038] 2. Precisely weigh β-CD, put it into a 500ml conical flask with a stopper, add an appropriate amount of distilled water (the ratio of β-CD to water is 1:6), heat to dissolve it completely, and lower it to the required temperature (60°C) , stirred at constant temperature, after diluting the volatile oil with absolute ethanol (1:1), slowly add it dropwise into the β-cyclodextrin solution (the ratio of β-CD to oil ...
Embodiment 2
[0045] Embodiment 2. Ningxintong preparation (capsule) is made of the crude drug of following weight ratio
[0046] [Prescription] Astragalus 15g Asarum 8g
[0047] Chuanxiong 15g Pueraria 10g
[0048] Holly hair 10g
[0049] [preparation method]
[0050] 1. Take 8 times the amount of Rhizoma Chuanxiong and Asarum in the prescription, add water, soak for 1.5 hours, refer to the "Chinese Pharmacopoeia" 2000 edition 1 appendix volatile oil determination method to extract volatile oil for 8 hours, release the oil layer after cooling to collect volatile oil and medicinal residues for later use;
[0051] 2. Dilute the volatile oil with absolute ethanol (1:1) for later use;
[0052] 3. Take astragalus and kudzu root and add 70% ethanol, which is 8 times that of the medicinal materials, and reflux extraction twice, each time for 2 hours, combine the ethanol extract, recover ethanol, extract and dregs for later use;
[0053] 4. Mix the medicinal residues (Chuanxiong, A...
Embodiment 3
[0058] Embodiment 3. Ningxintong preparation (oral liquid) is made of the crude drug of following weight ratio
[0059] [Prescription] Astragalus 20g Asarum 10g
[0060] Chuanxiong 20g Pueraria 15g
[0061] Holly hair 15g
[0062] [preparation method]
[0063] 1. Take Ligusticum chuanxiong and Asarum in the prescription, add 10 times the amount of water, soak for 2 hours, refer to the "Chinese Pharmacopoeia" 2000 edition one appendix volatile oil determination method to extract volatile oil for 10 hours, release the oil layer after cooling, and set aside;
[0064] 2. Take Radix Astragali and Radix Puerariae and add 70% ethanol, which is 10 times that of medicinal materials, reflux extraction 3 times, each time for 3 hours, combine ethanol extracts, recover ethanol, and set aside;
[0065] 3. Medicinal residues (Chuanxiong, Asarum, Astragalus, and Pueraria radicis) are mixed with Ilex pubescens and extracted with water for 3 times, each time for 2 hours, and filt...
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