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Preparation method of non-porous or porous polymer microsphere of surface function

A polymer microsphere and surface functional technology, applied in the field of functional polymer materials, can solve problems such as application limitations, and achieve the effects of controllable particle size, uniform particle size distribution, and uniform pore size distribution

Inactive Publication Date: 2007-10-03
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Found through literature search to prior art, Frechet etc. published " Polymeric porogens used in the preparation of novel monodispersed macroporous polymeric separationmedia for High-performance liquid chromatography" ("Preparation of a new type of monodisperse macroporous polymer dispersion medium for high-performance liquid chromatography using a polymer porogen"), using the method of seed polymerization to prepare a monodisperse porous polymer Microspheres, using linear polymers or both linear polymers and small molecules as porogens to prepare polymer microspheres, which can be used as packing, adsorption and separation materials for chromatographic columns, but due to Its surface has no reactive functional groups, so its application in the biomedical field is also limited

Method used

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  • Preparation method of non-porous or porous polymer microsphere of surface function

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Experimental program
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Embodiment 1

[0029] This embodiment 1 is implemented under the following conditions of implementation and technical requirements:

[0030] (1) After styrene and methacrylic acid are subjected to reduced pressure distillation, the divinylbenzene is washed with a 10% NaOH aqueous solution by mass percentage, and then dried with anhydrous magnesium sulfate;

[0031] (2) Mix 30g of the above-mentioned treated styrene monomer, 0.06g of azobisisobutyronitrile, 2.0g of polyvinylpyrrolidone, 60g of ethanol and 8g of water, stir evenly, pass nitrogen for 15 minutes, and use under nitrogen protection It was heated up to 65°C and reacted at a constant temperature for 24 hours. After the reaction, the reaction solution was centrifuged at high speed to obtain polymer microspheres. The microspheres were washed with absolute ethanol for 3 times and then dried to obtain seed polymer microspheres. The number-average particle diameter Dn of the seed polymer microspheres is 2.1 μm, and the variation coeffici...

Embodiment 2

[0037] This embodiment 2 is implemented under the following conditions of implementation and technical requirements:

[0038] (1) Methyl methacrylate and acrylic acid are distilled under reduced pressure for use, and the ethylene glycol di(methacrylate) ester is first washed with an aqueous NaOH solution with a mass percent concentration of 1%, and then dried with anhydrous magnesium sulfate ,stand-by;

[0039] (2) Mix 15g of the above-mentioned treated methyl methacrylate monomer, 0.15g of azobisisobutyronitrile, 1.55g of polyvinylpyrrolidone, 120g of methanol and 35g of water, stir well, pass nitrogen for 15 minutes, and Under protection, heat up to 80°C, react at a constant temperature for 12 hours, centrifuge the reaction solution at high speed after the reaction to obtain polymer microspheres, wash them with absolute ethanol for 3 times, and then dry them to obtain seed polymer microspheres. The number-average particle diameter Dn of the molecular microspheres is 1.8 μm,...

Embodiment 3

[0045] This embodiment 3 is implemented under the following conditions of implementation and technical requirements:

[0046] (1) After styrene and methacrylic acid are subjected to vacuum distillation treatment, the divinylbenzene is washed with an aqueous NaOH solution with a mass percent concentration of 20%, and then dried with anhydrous magnesium sulfate, and then used;

[0047] (2) Mix 10 g of the above-mentioned treated styrene monomer, 0.5 g of azobisisobutyronitrile, 2.0 g of polyvinylpyrrolidone, 30 g of ethanol and 70 g of ethylene glycol methyl ether, stir well, and pass nitrogen for 5 minutes. Under the protection of nitrogen, the temperature was raised to 65°C, and the reaction was carried out at a constant temperature for 48 hours. After the reaction, the reaction solution was centrifuged at high speed, and the obtained polymer microspheres were washed with absolute ethanol for 3 times and dried to obtain seed polymer microspheres. The number-average particle di...

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Abstract

This invention relates to a preparation method of surface functional, imperforation or multihole polymer microsphere, belongs to functional polymer material technosphere. The steps: remove polymerization inhibitor in alkene monomer; add mono-olefin monomer to continuous phase solvent, form reaction system, inlet nitrogen, takes reaction under homothermal condition to obtain seed polymer microsphere; mix seed polymer microsphere solution and activator, form first-order swelling reaction solution; then add mono-olefin monomer, monomer with functional group and cross-linking agent, and make them swell to seed microballoon sphere, form second grade swelling reaction solution; finally add water-solubility polymerization inhibitor, form blending reaction solution, isothermal reaction, ultimately separate to obtain imperforation polymer microsphere with functional surface; or use organic solvent to extract to obtain multihole polymer microsphere with functional surface.

Description

technical field [0001] The invention relates to a method for preparing polymer microspheres, in particular to a method for preparing surface-functionalized non-porous or porous polymer microspheres, and belongs to the technical field of functional polymer materials. Background technique [0002] Polymer microspheres have many unique performance advantages: large specific surface area, controllable and uniform particle size, and wide source of raw materials; materials and preparation processes can be selected according to needs, and polymer microspheres with required functional groups on the surface can be prepared. Ball; it can also be made into solid, hollow, porous, vesicle and some irregular shapes as required. Therefore, polymer microspheres are used in a wide range of fields, including coatings in traditional fields, surface processing of paper, building materials, and medical medicine, biochemistry, and electronic information in high-tech fields. In recent years, espec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F2/00C08F12/08C08F20/06C08F12/36C08F4/34C08F2/44
Inventor 孙康窦红静张鹏飞
Owner SHANGHAI JIAO TONG UNIV
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