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Anethol trithione drop pills, and preparation method

A technology of sulfur dripping pills and anisitrazine, which is applied in the field of anisitrazine dripping pills and preparation thereof, can solve the problems of difficulty in swallowing, low bioavailability, long disintegration time, etc., and is beneficial to labor protection and environmental protection, High bioavailability and the effect of reducing dust pollution

Inactive Publication Date: 2007-10-10
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have disadvantages such as long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of the drug effect.
Easy to split, change color, absorb moisture, etc. during storage, the quality is unstable, and it is also difficult to adapt to patients who have difficulty swallowing

Method used

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  • Anethol trithione drop pills, and preparation method
  • Anethol trithione drop pills, and preparation method
  • Anethol trithione drop pills, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: In this example, through the formulation of anetellithin and a single matrix, the operation is carried out according to the preparation method in the [specific implementation method]. Hardness, dissolving time, etc. are used as indicators to observe the influence of the weight ratio of the drug to the single matrix on the product involved in the present invention. The test results are shown in Table 1.

[0026] Table 1 Tests of drug and single matrix formulation (all drugs are 1 part)

[0027]

[0028] Note: 1. The coolant is simethicone oil, and the cooling temperature is 8-5°C; the heat preservation temperature of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 grains / minute.

[0029] 2. The above results show that the indicators of No. 2, 3, 4, 6, 7, and 8 tests are better, that is, the drug can be dripped smoothly when the ratio of drug to matrix is ​​1:3-1:9. However, in consideration of factors such as dosage, the ...

Embodiment 2

[0030] Example 2: In this example, through the formula of anetellithin and mixed matrix, operate according to the preparation method in [specific implementation mode], the coolant is simethicone oil, drop pills, and select roundness, pill weight difference, Hardness, dissolving time etc. are investigation indexes, observe the influence of the weight ratio of medicine and mixed matrix on the product involved in the present invention, test result is shown in Table 2.

[0031] Table 2 Drug and mixed matrix formulation test (1 part of drug)

[0032]

[0033] Note: 1. The coolant is simethicone oil, and the cooling temperature is 8-5°C; the heat preservation temperature of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 grains / min.

[0034] 2. The above results show that the indicators of No. 2, 3, 5, 6, 8, 9, 11, and 12 tests are all good, that is, when the ratio of drug to matrix is ​​1:1-1:9, it can be dripped smoothly. However, in consi...

Embodiment 3

[0035] Embodiment 3: In this embodiment, different coolants are selected, and the coolant is simethicone, liquid paraffin, vegetable oil, and polyethylene glycol is selected as a single matrix 6000 , the mixed matrix chooses polyethylene glycol 6000 : the formula of poloxamer=1:0.2, operate according to the preparation method in [the specific embodiment], drip dripping pill, select roundness, pill weight difference, hardness, dissolving time etc. as investigation index, observe different The impact of coolant on the products involved in the present invention, the test results are shown in Table 3.

[0036] Table 3 Experiments using different coolants (drug: matrix = 1:2)

[0037]

[0038] Note: 1. The cooling temperature is 8-5°C; the heat preservation and dripper temperature is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0039] 2. The above results show that the indicators of No. 1 and No. 2 tests are better, that is, when the above-mentioned diff...

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Abstract

A dripping pill of anethol trithione for treating cholecystitis, cholelithiasis and acute or chronic hepatitis is prepared from the anethol trithione and the matrix of dripping pill. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an anethol trithione dripping pill formulated with a dropping pill matrix and a preparation method thereof. Background technique [0002] Anetetithione, also known as bilevitamin, cyclopenthione. The chemical name is 5-(p-methoxyphenyl)-1.2-dithiocyclopent-4-ene-3-thione. Can enhance liver glutathione (GSH) level, significantly enhance glutamyl cysteine ​​synthetase (GCS), glutathione reductase (GSSG-R) and glutathione sulfur transferase (GSH-S -Tx) activity, reduce glutathione peroxidase (GSH-Px) activity, thereby enhancing cell viability, promoting the secretion and discharge of bile and the secretion of bile pigment, bile acid and cholesterol, and enhancing liver detoxification function. In the body, it is mainly metabolized into the combination of p-hydroxyphenyltrithione and gluconic acid and non-toxic sulfate, which is excreted through the kidneys. It is cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385A61K9/20A61P1/16
Inventor 陈茜滕慧丽
Owner 陈茜
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