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Cylindrical member and process for producing the same

A manufacturing method and technology of cylindrical body, which can be applied in the direction of prosthesis, textiles and papermaking, and devices with tubular structure of human body, etc. It can solve the problems of large differences in blood vessels, achieve excellent elastic recovery rate, excellent attachment growth, and cell infiltration excellent effect

Inactive Publication Date: 2007-10-24
TEIJIN LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]However, the foothold material of the nanofibers discussed so far is a uniform porous body, and its structure is quite different from that of blood vessels as biological tissues

Method used

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  • Cylindrical member and process for producing the same
  • Cylindrical member and process for producing the same
  • Cylindrical member and process for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0107] The present invention is illustrated in detail based on the following examples. However, the present invention is not limited to these Examples.

[0108] (1) The polymers used in this example are as follows.

[0109] PLGA (50 / 50): lactic acid (50mol%)-glycolic acid (50mol%) copolymer, intrinsic viscosity = 1.08dL / g (in HFIP, 30°C) manufactured by Absorbable Polymers International,

[0110] PLCA (77 / 23): lactic acid (77mol%)-caprolactone (23mol%) copolymer, Mw=2.5×10 5 , Manufactured by Taki Chemical Co., Ltd.,

[0111] PLCA (68 / 32): lactic acid (68mol%)-polycaprolactone (32mol%) copolymer, Mw=1.75×10 5 , Manufactured by Taki Chemical Co., Ltd.,

[0112] Vinyl chloride, ethanol: Wako Pure Chemical Industries, Ltd.

[0113] (2) The physical properties of the cylinder were measured by the following methods.

[0114] Average fiber diameter: Measured at 20 locations with a digital microscope (KEYENCE, VHX DIGITALMICROSCOPE), the average value thereof was taken as the a...

reference example 2

[0133] Reference Example 2 (Manufacture of Cylindrical Body A)

[0134] Assemble the device shown in Figure 2. The inner diameter of the nozzle 1 is 0.8 mm. The distance from the nozzle 1 to the collecting-side electrode 5 was set at 10 cm. As the collection-side electrode 5 , a stainless steel rod with an outer diameter of 4 mm and a length of 20 cm was used.

[0135] The spinning stock solution A is put into the holding tank 3, the voltage between the discharge side electrode 4 and the collecting side electrode 5 is set to 1 kV, and the collecting side electrode 5 is rotated at 100 rpm while the spinning stock solution A is It was sprayed toward the collecting-side electrode 5 for 5 minutes, and a cylindrical body A was obtained. Repeat the same operation to obtain five cylinders A. The average fiber diameter of the fibers constituting the cylindrical body A is 4 μm, the length of the cylindrical body A is 10 cm, the outer diameter is 4.1 to 4.2 mm, the inner diameter is...

reference example 3

[0136] Reference example 3 (manufacture of cylindrical body B)

[0137] The operation of Reference Example 2 was repeated except that the spinning stock solution B was used instead of the spinning stock solution A, and the cylindrical body B was produced. The average fiber diameter of the fibers constituting the cylindrical body B is 4 μm, the length of the cylindrical body B is 10 cm, the outer diameter is 4.1 to 4.2 mm, the inner diameter is 4 to 4.1 mm, and the thickness is 90 to 110 μm.

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Abstract

A cylindrical member that excels in elastic modulus and elastic recovery rate and is suitable to a scaffold material for revascularization; and a cylindrical member that has an outermost layer of high air permeability, excelling in cell infiltratability, and is suitable to a scaffold material for revascularization. There is provided a hollow cylindrical member of 0.5 to 50 mm outside diameter and 200 to 5000 [mu]m thickness comprising concentrically arranged multiple layers, wherein each of the layers consists of an aliphatic polyester fiber of 0.05 to 50 [mu]m average diameter.

Description

technical field [0001] The present invention relates to a cylindrical body having multiple layers composed of aliphatic polyester fibers and a method for producing the same. Background technique [0002] In recent years, as a treatment method for greatly damaged or lost biological tissue, research on regenerative medicine that utilizes cell differentiation and reproductive ability to rebuild the original biological tissue has become active. Angiogenesis is also one of them, and research is under way to regenerate blood vessels by cutting off blood vessels damaged by congenital or disease, and cross-linking the incision to become a material for regeneration. [0003] As such a footing material, a catheter auxiliary material made of polyurethane fiber or the like and having a hole with an inner diameter of 0.3 to 3 cm has been proposed (Patent Document 1). However, biodegradable materials are preferred in regenerative medicine. [0004] In addition, a foothold material compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/00
CPCA61L27/20A61L27/18D01D5/0038A61F2/06D01F6/625Y10T428/24322Y10T428/24132Y10T428/249953Y10T428/249986Y10T428/31786C08L67/04C08L5/04A61L27/00
Inventor 北薗英一兼子博章三好孝则小村伸弥斋藤亮
Owner TEIJIN LTD
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