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Quality standard of Moluo Dan.and detecting method thereof

A quality control method and content technology, applied in the direction of measuring devices, material inspection products, testing pharmaceutical preparations, etc., can solve the problems of no content measurement indicators, ineffective control of product quality, and few detection indicators

Active Publication Date: 2008-01-23
HANDAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to the quality standard of Morodanyuan, Poria, Alisma, capillary, dendrobium, gallinacea, Burnet, Scrophulariaceae, and Puhuang are microscopically identified, and Corydalis Corydalis is identified by TLC. There are few detection indicators and no content determination indicators. , cannot effectively control product quality

Method used

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  • Quality standard of Moluo Dan.and detecting method thereof
  • Quality standard of Moluo Dan.and detecting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Embodiment 1: the quality control method of Morodan

[0107] Identification method:

[0108] A. Take molodan and observe under a microscope: the irregular branched mass is colorless and dissolves in chloral hydrate solution; the hyphae are colorless or light brown, with a diameter of 4-6 μm; the parenchyma cells are round and elliptical Shaped pits, integrated pit groups; non-glandular hairs T-shaped, head cells are fibrous; round cells on the fiber surface contain small round silicon blocks, arranged in rows; colorless irregular blocks are easy to see; wood Thrombus cells are dark yellow-brown, rectangular or long polygonal, and some cells are filled with yellow-brown contents and oil particles; stone cells are yellow-brown or colorless, sub-rectangular, sub-circular or irregular in shape, with a diameter of about 94 μm; pollen grains yellowish brown, sub-circular in shape, about 30 μm in diameter, with net-like carvings on the outer wall;

[0109] B. Take 9g of Molo...

Embodiment 2

[0118] Embodiment 2: the quality control method of Morodan

[0119] Identification method:

[0120] B. Take 10g of Molodan, cut it into pieces, add 11g of diatomaceous earth, grind it evenly, add 45ml of water, add 5ml of hydrochloric acid, extract under reflux for 30 minutes, filter, add 45ml of ethyl acetate to the filtrate each time, extract 4 times, and combine the solvents Ethyl acetate was evaporated to dryness, and the residue was dissolved in 1ml of chloroform as a test solution; another 1g of Ophiopogon japonicus reference drug was taken, and the reference drug solution was prepared in the same way; according to the thin-layer chromatography test, the above two solutions were absorbed Each 6 μl was spotted on the same silica gel G thin-layer plate, developed with 9:1 chloroform-acetone as the developer, taken out, dried in the air, sprayed with 9% sulfuric acid ethanol solution, and heated at 105°C until the spots became apparent. The color is clear; in the chromatog...

Embodiment 3

[0128] Embodiment 3: the identification method of Morodan:

[0129] B. Take 17g of Molodan, cut it into pieces, add 7g of diatomaceous earth, grind well, add 55ml of water, add 6ml of hydrochloric acid, extract by cold soaking for 30 minutes, filter, add 35ml of ethyl acetate to the filtrate each time, extract twice, and combine the solvents Ethyl acetate was evaporated to dryness, and the residue was dissolved by adding 1ml of chloroform, which was used as the test solution; another 1g of Ophiopogon japonicus reference drug was taken, and the reference drug solution was prepared in the same way; 9 μl, respectively spot on the same silica gel G thin-layer plate, use 5:4 chloroform-acetone as developer, develop, take out, dry in the air, spray with 11% sulfuric acid ethanol solution, heat at 105°C until the spots develop color Clear; in the chromatogram of the test product, there are spots of the same color at the position corresponding to the chromatogram of the control medici...

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Abstract

The invention discloses a method for controlling the quality of Moluo Dan, which comprises the discrimination method for thin layer of Ophiopogon japonicus, pseudo-ginseng, Sanguisorba officinalis, angelica sinensis, Ligusticum wallichii and corydalis tuber, as well as the content determining of paeoniflorin (C23H28O11) in white Chinese herbaceous peony. The white Chinese herbaceous peony contained in each 1g of Moluo Dan is expressed by C23H28O11, which shall not be less than 0.8 mg.

Description

technical field [0001] The present invention relates to the quality control method of moluodan, particularly relate to the TLC identification method of Ophiopogon japonicus, Panax notoginseng, Burnet, Angelica, Rhizoma Chuanxiong, Corydalis Corydalis and Paeoniflorin (C 23 h 28 o 11 ) content determination. Background technique [0002] Chronic atrophic gastritis is a common and frequently-occurring disease. It is generally believed that atrophic gastritis is a precancerous lesion of the stomach or may be a latent factor of gastric cancer. Therefore, the disease has attracted extensive attention from the medical community both at home and abroad. For chronic atrophic gastritis, there is no satisfactory treatment at home and abroad so far, and there is also a lack of effective Chinese and Western medicines. After years of clinical application, Moluodan has proved to have a significant effect on the treatment of atrophic gastritis and general stomach diseases. [0003] Mor...

Claims

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Application Information

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IPC IPC(8): G01N30/00G01N30/90G01N21/84G01N21/78G01N30/02G01N33/15
Inventor 陈致慜李春雷霍志金
Owner HANDAN PHARMA
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