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Artemether cataplasma and its application

A technique of artemether and poultice is applied in the field of external dosage form of artemether - poultice, which can solve problems such as inconvenience of use, poor use compliance, injection pain, etc., and achieves convenient use, mild antipyretic effect, no fever The effect of hypothermia

Inactive Publication Date: 2010-05-19
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the disadvantages of injection pain and inconvenient use, patients, especially children, have poor compliance

Method used

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  • Artemether cataplasma and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Backing layer: non-woven fabric

[0069] Cover lining: polyester film

[0070] The composition of the medicated ointment layer is as follows by weight:

[0071] Artemether (micronized) 0.3g

[0072] Gelatin 0.7g

[0073] Tragacanth Gum 0.7g

[0074] Macrogol-400 0.3g

[0075] Polyacrylic acid 0.3g

[0076] Glycerin 0.2g

[0077] Zinc oxide 0.04g

[0078] Azone 0.01g

[0079] borneol 0.05g

[0080] Preparation method: pulverize artemether, weigh gelatin and tragacanth gum according to the prescription amount, add 7 grams of water, heat in a water bath to dissolve, mix polyacrylic acid, glycerin and zinc oxide evenly, add to the above glue, stir Mix evenly, then add polyethylene glycol-400 to disperse the suspension of borneol and artemether, and finally add azone to obtain a paste. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyester film, and cut it to get it.

Embodiment 2

[0082] Backing layer: non-woven fabric

[0083] Cover lining: aluminum foil-polyethylene composite film

[0084] The composition of the medicated ointment layer is as follows by weight:

[0085] Artemether 0.02g

[0086] Sodium polyacrylate 3.0g

[0087] Gelatin 3.5g

[0088] Polyvinyl alcohol 3.05g

[0089] Glycerin 3.5g

[0090] Zinc Oxide 2.3g

[0091] Azone 0.03g

[0092]Propylene Glycol 4.55g

[0093] Menthol 0.05g

[0094] Preparation method: pulverize artemether, weigh gelatin, sodium polyacrylate, and polyvinyl alcohol according to the prescription amount, add 15.0 grams of water to make swelling, stir and mix evenly, mix glycerin, zinc oxide, and azone evenly, add the above swelling In the solution, stir and mix evenly, and then add the suspension of menthol and artemether dispersed with propylene glycol and azone to obtain a paste. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyester film, and cut it into a suitable size.

Embodiment 3

[0096] Backing layer: non-woven fabric

[0097] Lid lining: Polyethylene film

[0098] The composition of the medicated ointment layer is as follows by weight:

[0099] Artemether (micronized) 0.04g

[0100] Sodium polyacrylate 1.9g

[0101] Carbomer 934p 1.5g

[0102] Glycerin 2.0g

[0103] Propylene Glycol 1.4g

[0104] Kaolin 1.0g

[0105] Citric acid 0.04g

[0106] Aluminum trichloride 0.08 g

[0107] Menthol 0.04g

[0108] Preparation method: 1. Weigh sodium polyacrylate and carbomer according to the prescription amount, add 10 grams of water to make swelling, add aluminum trichloride, stir and mix evenly; 2. Mix glycerin and kaolin and add to 1; 3. Use propylene glycol to dissolve menthol and artemether powder into a suspension and add to 2; 4. Finally, add citric acid, stir and mix evenly to obtain a paste. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyethylene film, cut it into pieces of appropriate size, and you get it.

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PUM

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Abstract

The present invention relates to an artemether cataplasma and the application. The cataplasma is prepared by artemether and proper excipients. The artemether cataplasma of the present invention is composed of three parts of a back lining layer, a paste body containing drug and a cover lining layer. The major part is the paste body containing drug which is prepared by artemether, adhesives, fillers, transdermal enhancers, moisturizing agents and other excipients according to a certain mixing ratio, each paste contain 20mg to 300mg of artemether. The cataplasma has the anti-fever effect and is characterized by fast acting, good moisture retention performance, good air permeability and comfortable usage, the product of the present invention has easy usage, small irritation on the skin and high compliance of the patients.

Description

technical field [0001] The present invention relates to the technical field of medicines, in particular to an external dosage form of artemether, which can be used for children and adults, and has a good therapeutic effect on fever caused by various infectious diseases and non-infectious diseases. its application. Background technique [0002] Catapult is an external preparation that dissolves or mixes drugs in a natural or synthetic water-soluble polymer matrix and spreads them on the backing material for sticking on the skin. It can act systemically or locally through transdermal absorption. It is also a transdermal drug delivery preparation, and its prototype is "poultica". Due to the rapid development of modern fine chemical industry and polymer material science, more excipients with superior performance have been provided for pharmacy. Therefore, cataplasm was first successfully developed by Japan in the 1970s. Up to now, a large number of cataplasms have been launch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/357A61L15/44A61P29/00
Inventor 丁江生
Owner KPC PHARM INC
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