The invention provides a traditional Chinese medicine cataplasm for acupoint application therapy of chronic fatigue syndrome and a preparation method thereof. The traditional Chinese medicine cataplasm comprises non-woven fabric, an anti-sticking film and drug-containing paste. The drug-containing paste comprises magnet, radix astragali, pilose asiabell root, toasted polygala root, poria with hostwood, fruit of Chinese magnoliavine, fructus amomi, albizia bark, sodium carboxymethylcellulose, sodium polyacrylate, carbomer, glycerin, gelatin, peach gum, polyvinylpyrrolidone, sodium hydroxide, borneol, menthol, purified water and ethanol. The preparation method comprises the following steps of respectively extracting extract I, volatile oil and extract II, preparing a matrix, adding borneol, menthol, the extract I, the volatile oil and the extract II into the matrix, carrying out stirring to obtain a uniform mixture, and carrying out coating, slicing and packaging to obtain the cataplasm. The traditional Chinese medicine cataplasm has substantial curative effects on chronic fatigue syndrome and does not cause allergy easily. The preparation method has simple processes and can be operated easily.