Diabetes treating medicine

A technology of diabetes and medicine, which is applied in the field of medicine for treating diabetes, and can solve the problems of reducing glucose speed and speed

Inactive Publication Date: 2008-03-05
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a medicine for treating diabetes, which aims to solve the problem of reducing the migration speed of glucose produced by starch to the intestinal tract, thereby reducing the speed of intestinal absorption of glucose, so that the glucose can be released slowly and absorbed evenly to treat diabetes

Method used

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  • Diabetes treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1. Extraction, separation and preparation of polygalacturonic acid methyl ester

[0036] Weigh a certain amount of pretreated Sapura seeds, pour them into a large beaker, add NaHCO 3 Adjust the pH to neutral, stir from time to time, and centrifuge after about 4-5 hours until the glue is completely dissolved. Get the supernatant pectin solution and concentrate it in vacuum at 50-60°C to 5% of the dry matter content, and add absolute ethanol dropwise at a speed of 1ml / min while stirring at 50-60°C (dropping to the alcohol concentration of the mixed solution is 55%-60%), the solution gradually becomes thinner, and then add absolute ethanol dropwise at a rate of 2.5ml / min (drop until the alcohol concentration of the mixed solution is 70%-80%). Centrifuge to discard the supernatant, soak and stir the precipitate with absolute ethanol, centrifuge, repeat twice until the leachate is colorless, and dry in a vacuum oven below 60°C. The white powder after drying is the ...

Embodiment 2

[0037] Embodiment 2. Preparation of polygalacturonic acid methyl ester gel

[0038] Generation of acid gel: get refined polygalacturonic acid methyl ester 1g, be dissolved in 300ml drinking water, form polygalacturonic acid methyl ester aqueous solution, under stirring condition, add dropwise the HCl of 1mol / L, to pH= At 3 o'clock, the polygalacturonic acid methyl ester forms a transparent gel, and the gel does not dissolve at 36.8°C.

[0039] Formation of Ca ion gel: Take 1 g of refined polygalacturonic acid methyl ester, dissolve it in 300ml drinking water to form polygalacturonic acid methyl ester aqueous solution, add supersaturated Ca(OH) dropwise under stirring condition 2 When the solution is 4.5ml, the polygalacturonic acid methyl ester forms a transparent gel, and the pH value of the gel is 7.3 at this time, and the gel does not dissolve at 36.8°C.

Embodiment 3

[0040] Example 3. Preparation of polygalacturonate methyl complex

[0041] Accurately weigh 100 g of purified polygalacturonic acid methyl ester powder and 20 g of calcium glycolate powder, and mix them uniformly to obtain polygalacturonic acid methyl ester complex.

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Abstract

The diabetes treating medicine has polymethyl galacturonate compound as effective component. When water solution of the polymethyl galacturonate compound is taken by diabetics while starch food is tanken, water solution of the polymethyl galacturonate compound and the starch food are mixed inside stomach to form gel under the action of gastric acid. The gel increases the adhesion of matter inside small intestine and forms one glue layer to lower the diffusion speed of starch formed glucose to intestinal mucosa cell and to delay and inhibit the absorption of small intestine to glucose, so as to lower the peak value of postprandial blood sugar. The macro molecular polymethyl galacturonate incapable of penetrating gastrointestinal tract barrier is ultimately excreted to outside body completely without being digested and absorbed.

Description

technical field [0001] The invention relates to a medicine for treating diabetes. Background technique [0002] Glucose is one of the main energy sources of cells and is transported to cells through the blood. Glucose has endogenous sources (glycogen source, fat source, amino acid source) and exogenous sources. The starch that people eat every day is the main source of exogenous glucose. When there is a problem with glucose metabolism, diabetes occurs when the blood sugar is abnormal. . Diabetes is a disease with a high incidence. The onset of diabetes has genetic congenital factors and environmental factors such as diet and exercise. Diabetes is a disease caused by chronic, systemic metabolic abnormalities caused by persistent hyperglycemia or impaired glucose tolerance. The cause of the disease is insulin production disorder, secretion disorder, or secreted insulin is a variety of reasons such as low ability of receptor cells. Hyperglycemia, especially postprandial hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61P3/10
Inventor 苏为平孙磊
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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