Artificial cerebrospinal fluid

An artificial, aqueous solution technology, applied in the field of artificial spinal fluid, can solve the problems of no clarification of the relationship between cleaning fluid or perfusion fluid cerebral edema, no report, and reducing the composition of cleaning fluid, etc., to achieve the effect of inhibiting ion exchange damage and reducing the risk rate

Active Publication Date: 2008-04-16
OTSUKA PHARM FAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Eliott did not report the composition of the washing solution that can reduce the occurrence of cerebral edema
[0005] In summary, it can be considered that the cleaning or perfusion fluid used in neurosurgery is the substance that causes or may cause high incidence of postoperative cerebral edema. However, the relationship between the composition of such cleaning fluid or perfusion fluid and cerebral edema has not yet been clarified. There are no reports of washing or perfusing fluids that prevent or reduce the occurrence of cerebral edema

Method used

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  • Artificial cerebrospinal fluid
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] The components shown in the following Table 1 as the upper chamber liquid and the lower chamber liquid were weighed, respectively mixed and dissolved in distilled water for injection to prepare 150 mL of the upper chamber liquid and 350 mL of the lower chamber liquid.

[0119] The obtained lower chamber fluid is filled into the lower chamber (chamber with a liquid outlet connected to the exhaust port) of the container 2 (made of polyethylene) of the container package for storing artificial spinal fluid shown in FIG. 1, depicted as the upper part), seal the mouth. In addition, the obtained upper chamber liquid was filled in the upper chamber before sealing (the chamber separated from the above-mentioned lower chamber by the partition wall, the chamber adjacent to the hanger part, drawn as the lower part in the figure) and sealed.

[0120] Table 1

[0121] Element

amount (g)

Upper chamber solution (per 150ml)

Calcium Chloride 2 Hydrate

Magn...

Embodiment 2

[0127] Except for removing glucose from the upper chamber fluid described in Example 1, the same procedure as in Example 1 was performed to prepare a container package for accommodating the artificial spinal fluid of the present invention, and the same experiment was carried out. The obtained results are shown in Table 3 below.

[0128] table 3

[0129] ingredients

Embodiment 3

[0131] Except for removing potassium dihydrogen phosphate from the lower chamber fluid described in Example 1, the same procedure as in Example 1 was performed to prepare a container package for accommodating the artificial spinal fluid of the present invention, and the same experiment was carried out. The obtained results are shown in Table 4 below.

[0132] Table 4

[0133] ingredients

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Abstract

An artificial cerebrospinal fluid comprising 120 to 160 mEq / L of a sodium ion, 1 to 6 mEq / L of a potassium ion, 75 to 155 mEq / L of a chlorine ion and 5 to 45 mEq / L of a bicarbonate ion; or an artificial cerebrospinal fluid further comprising at least one component selected from 10 g / L or less of a reducing sugar, 5 mmol / L or less of phosphoric acid, 5 mEq / L or less of a calcium ion and 5 mEq / L or less of a magnesium ion in addition to the components mentioned above. By using the artificial cerebrospinal fluid as a washing fluid or a perfusion fluid in the field of neurosurgery including intracranial surgery or a fluid replenisher for the lost cerebrospinal fluid, the development of cerebral edema can be prevented or reduced and a brain cell disorder can also be inhibited.

Description

technical field [0001] The present invention relates to an artificial spinal fluid, especially in the field of intracranial surgery or neurosurgery, the artificial spinal fluid used for cleaning or perfusing or replenishing the loss of cerebrospinal fluid, a container package for containing the artificial spinal fluid, and the use of the artificial spinal fluid A method for inhibiting the occurrence of cerebral edema with artificial spinal fluid and a method for inhibiting the occurrence of brain cell damage (disorder) using the artificial spinal fluid. Background technique [0002] Currently, physiological saline, lactated Ringer's solution, etc. are used as artificial spinal fluid in order to supplement the loss of cerebrospinal fluid (CSF) during neurosurgery. In addition, these artificial spinal fluids are also used to wash or perfuse surgical sites (intraventricular washing fluid or perfusion fluid) (see Non-Patent Documents 1-3). However, when physiological saline is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K31/7016A61K33/14A61P7/10A61P19/00A61J1/05A61K9/08A61K33/20A61K47/04A61K47/26A61P7/08A61P43/00
CPCA61K33/00A61J1/10A61K33/14A61J1/2093A61K31/7016A61J2001/2024A61K33/10A61K33/42A61J1/2024A61P7/08A61P7/10A61P19/00A61P43/00A61K2300/00
Inventor 土居和久森冈雄二朗川野刚
Owner OTSUKA PHARM FAB INC
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