Medicinal composition containing mongolian snakegourd and notoginseng

A composition and technology of guarlou extract, which are applied in the field of medicine and achieve the effects of high content, good preparation stability and good quality

Inactive Publication Date: 2011-02-09
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, using the interaction between Trichosanthes or Trichosanthes extract and Panax notoginseng or Panax notoginseng extract to prepare medicines for treating cardiovascular and cerebrovascular diseases, etc., has not been reported yet.

Method used

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  • Medicinal composition containing mongolian snakegourd and notoginseng
  • Medicinal composition containing mongolian snakegourd and notoginseng
  • Medicinal composition containing mongolian snakegourd and notoginseng

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The preparation of embodiment 1 Trichosanthes quince extract

[0088] 1, the preparation method of Trichosanthes quince extract

[0089] Preparation of Trichosanthes extract:

[0090]Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times the amount of water each time, reflux extract for 2 hours, filter, combine filtrates, concentrate to a relative density of 1.10-1.15 (60°C ) concentrated solution, add ethanol until the content reaches 80%, leave it overnight, take the supernatant overnight, recycle the ethanol until it has no alcohol smell, concentrate under reduced pressure to a thick paste, and vacuum dry to obtain the crude extract of Trichosanthes trichosanthes.

[0091] After dissolving the above-mentioned Trichosanthes quinquefolius extract with an appropriate amount of water, shake and extract twice with an equal amount of petroleum ether, shake and extract the water liquid three times with an...

Embodiment 2 10

[0099] The preparation of embodiment 2 Panax notoginseng extract

[0100] 1. The preparation method of Panax notoginseng extract

[0101] Take the notoginseng medicinal material, crush it into a coarse powder, add ethanol to reflux and extract three times, each time for 3 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water to an appropriate amount (each 1ml is equivalent to 2g of the original medicinal material), refrigerate for 24 hours, filter After that, the filtrate was added to the treated weakly polar macroporous resin column, first eluted with 2 times the column volume of water, then 4 to 5 times the 80% ethanol, collected the eluate, recovered the ethanol and Vacuum drying, that is.

[0102] 2. Determination of the content of Panax notoginseng extract

[0103] Determination according to high performance liquid chromatography (Appendix VI D)

[0104] Chromatographic conditions and system adaptability test: Octadecylsilane b...

Embodiment 3

[0112] The preparation of embodiment 3GHS tablet

[0113] Prescription one:

[0114] Trichosanthes extract 71g (equivalent to 1000g of raw medicinal materials)

[0115] Panax notoginseng extract 8.4g (equivalent to 200g of raw medicinal materials)

[0116] 120g pregelatinized starch

[0117] Microcrystalline Cellulose 40g

[0118] Low-substituted hydroxypropyl cellulose 40g

[0119] 2% HPMC aqueous solution appropriate amount

[0120] Magnesium Stearate 6g

[0121] Carboxymethyl Starch Sodium 12g

[0122] A total of 1000 tablets were prepared

[0123] Prescription two:

[0124] Trichosanthes extract 71g (equivalent to 1000g of raw medicinal materials)

[0125] Panax notoginseng extract 1 2.6g (equivalent to 300g of the original medicinal material)

[0126] 120g pregelatinized starch

[0127] Microcrystalline Cellulose 40g

[0128] Low-substituted hydroxypropyl cellulose 40g

[0129] 2% HPMC aqueous solution appropriate amount

[0130] Magnesium Stearate 6g

[...

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Abstract

The invention belongs to the field of pharmaceutical technology. The invention discloses a medicine combination of snakegourd fruit or the extract thereof and pseudoginseng or the extract thereof as well as the preparation method thereof; the invention also discloses the application of the medicine combination on the medicines for treating cerebrovascular diseases and the preparations containing the medicine combination. The effective ingredients of the medicine combination are prepared by the following raw medicines by weight: 200-5000 parts of snakegourd fruit and 100-5000 parts of pseudoginseng, or 4-400 parts of snakegourd fruit extract and 4-250 parts of pseudoginseng extract. The invention can be prepared into any dosage forms acceptable in clinical or pharmacy, and the preferred preparation is oral preparation or injection. The two medicines in the invention have synergistic function and achieve the functions of anti-myocardial ischemia, anti-platelet aggregation, reducing myocardial infarct size and decreasing heart rates together. The invention has significantly increasing curative effect than single administration of snakegourd fruit, the extract thereof, pseudoginseng and the pseudoginseng thereof.

Description

[technical field] [0001] The present invention relates to a medicinal composition of Trichosanthes quince or its extract and Panax notoginseng or its extract and its preparation method, its application in the preparation of medicines for treating cardiovascular and cerebrovascular diseases, and a preparation containing the medicinal composition, belonging to the technical field of medicine . [Background technique] [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/428A61P9/10A61P9/12A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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