Method for preparing benzimidazole

A technology of benzimidazole and phenylenediamine, applied in the field of preparation of benzimidazole, can solve problems such as long reaction time, and achieve the effects of rapid synthesis, easy access to equipment, and convenient production scale-up
CN101235017AInactive Publication Date: 2008-08-06SOUTH CHINA NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA NORMAL UNIVERSITY
Publication Date
2008-08-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a benzimidazole preparation method for drug, catalyst and metal surface treatment agent, which uses o-phenylenediamine and aldehyde as raw materials, uses cheap air as oxidant and uses intermittent microwave heating method to synthesize benzimidazole compound. The invention eliminates the o-phenylenediamine and carboxyl acid (or ester) condensation method of traditional benzimidazole synthesis and eliminates the synthesis method with long reaction time and failure in large scale preparation, to directly synthesis o-phenylenediamine, aldehyde and air in microwave, optimizes reactant proportion, microwave heating time and catalyst or the like, with high-speed reaction, simple operation, low device demand and high yield, which can circulate to continuously synthesize benzimidazole to support the industrial production of benzimidazole compound.
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Description

technical field

[0001] The invention relates to a preparation method of benzimidazole used for medicine, catalyst, metal surface treatment agent and the like. technical background

[0002] Benzimidazoles have a wide range of biological activities, such as anticancer, antifungal, anti-inflammatory, treatment of hypoglycemia and physiological disorders, etc., which are of great significance in medicinal chemistry; and can be used to simulate natural superoxide dismutase (SOD ) active sites to study biological activity, as well as new epoxy resin curing agents, catalysts and surface treatment agents for certain metals, and can also be used as intermediates in organic synthesis reactions. Therefore, the synthetic method of benzimidazole compound has caused people's great interest.

[0003] At present, there are many reported methods for synthesizing benzimidazole compounds, mainly through the condensation reaction of o-phenylenediamine and carboxylic acid and their derivatives ...

Claims

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