Method for preparing nano-micrometre composite microsphere

A kind of composite microsphere and nanotechnology, which is applied in the field of preparation of nano-micron composite microspheres, can solve the problems of poor stability, limit the application and lifespan of nano-micron composite microspheres, and achieve the effect of improving application and lifespan

Inactive Publication Date: 2008-08-13
SUZHOU NANOMICRO TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above preparation methods all use Coulomb force to absorb the charged nanoparticles on the surface to the surface of the oppositely charged microspheres to prepare nano-micron composite microspheres. This method has the advantages of simple preparation and large specific surface area of ​​the prepared particles. However, since the surface of the nanoparticle and the microsphere is made by Coulomb force, the stability of the composite microsphere is poor, and the nanoparticle will be released in a strongly polar medium. Ball application and life

Method used

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  • Method for preparing nano-micrometre composite microsphere
  • Method for preparing nano-micrometre composite microsphere
  • Method for preparing nano-micrometre composite microsphere

Examples

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Embodiment 1

[0032] Example 1: Synthesis of monodisperse latex particles P (St-MMA-MAA) with negatively charged surfaces:

[0033] 0.4g of ammonium persulfate, 0.8g of ammonium bicarbonate and a certain amount of methacrylic acid (0.05-0.6g) were dissolved in 10mL of deionized water (solution A). Take 22.5mL of styrene, 1.25mL of methyl methacrylate, and 110mL of deionized water in a 250mL three-necked flask, mix and stir, pass N 2 protection. When the temperature of the liquid in the bottle rises to 70°C, quickly add solution A to the mixed liquid in the bottle. Stirring was maintained at 70°C for 8 hours to obtain a homogeneous emulsion.

Embodiment 2

[0034] Example 2: Synthesis of monodisperse microspheres with negatively charged sulfonic acid functional groups on the surface:

[0035] Add 10 grams, 5 microns, and a degree of cross-linking of 55%, monodisperse polystyrene / divinylbenzene microspheres to 50 grams of concentrated sulfuric acid, then heat to 120 degrees and maintain this temperature for 10 hours. The microspheres are separated by filtration, centrifugation, etc. The surface of the prepared microspheres has negatively charged sulfonic acid functional groups.

Embodiment 3

[0036] Example 3: Synthesis of monodisperse microspheres with positively charged carboxyl functional groups on the surface:

[0037] Add 10 grams, 5 microns, cross-linking degree of 10%, monodisperse polystyrene / divinylbenzene microspheres into the dichloroethane solvent, add chloromethyl fan under the protection of nitrogen, and react for 5 hours. The microspheres prepared after filtration have chloromethyl functional groups on the surface. These microspheres react with ammonia to prepare amino microspheres with positive charges on the surface.

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Abstract

The present invention provides a method for preparing nanometer micron composite spheres, a nanometer particle having surface function group is linked to the specialised spheres surface by chemical method, so as to prepare stable nanometer micron composite spheres, and enhance the application and life of the composite spheres, these nanometer micron composite spheres are used for high-effect ion chromatography fillings, biomolecule separation and analyzing medium, cell separating magnetic spheres, catalyst and zymophore, diagnostic reagent, medical controlled released carrier etc.

Description

Technical field [0001] The invention relates to a method for preparing nano-micron composite microspheres. Background technique [0002] Functionalized nano-micron particles are widely used in biopharmaceuticals, medical diagnosis, enzyme catalysis, biotechnology, pharmaceutical preparations, flat panel displays and other industries due to their special size and high specific surface area. Therefore, how to prepare nano-micron spheres with controllable properties, especially nano-micron composite microspheres with controllable multi-functionality, size and uniformity, has always been the focus and difficulty of research. [0003] The Institute of Chemistry of the Chinese Academy of Sciences proposed the use of monodisperse quaternized cross-linked polystyrene nano ions with a size of less than 0.5 microns in the Chinese patent application number CN85100884, titled "High-efficiency anion exchange agglomerated microsphere resin". A high-efficiency chromatographic separation medium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J20/22G01N33/48
Inventor 江必旺
Owner SUZHOU NANOMICRO TECH CO LTD
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