Method for preparing 4-aminophenyl-beta-hydroxyethyl sulfone sulfate
A technology of hydroxyethyl sulfone and aminophenyl, applied in the field of preparation of sulfate, can solve the problems of high environmental protection cost, excessive chlorosulfonic acid, etc., and achieves the effects of easy handling, pure color and low production
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specific Embodiment approach 1
[0008] Specific embodiment one: the preparation method steps of 4-aminophenyl-beta-hydroxyethyl sulfone sulfate in the present embodiment are as follows: one, with beta-mercaptoethanol and p-nitrohalobenzene according to the ratio of 1~1.5:1 The molar ratio is dissolved in the solvent, and the temperature is raised to 30-50°C while stirring, and then the temperature is controlled at 30-50°C, and the acid-binding agent is added dropwise within 2-4 hours, and the reaction is kept for 2-6 hours. 20-37% hydrochloric acid makes the reaction solution neutral, then suction filtration, vacuum distillation, hot water washing three times, after liquid separation, 4-nitrophenyl-β-hydroxyethyl sulfide is obtained; two, the 4- After mixing nitrophenyl-β-hydroxyethyl sulfide, catalyst and water, add the oxidant dropwise at 30-100°C for 2-4 hours, then stir at constant temperature for 2-4 hours, then cool to room temperature. Add a sodium carbonate solution with a mass concentration of 10-20...
specific Embodiment approach 2
[0009] Embodiment 2: This embodiment is different from Embodiment 1 in that the molar ratio of β-mercaptoethanol to p-nitrohalobenzene in step 1 is 1.1:1. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0010] Embodiment 3: This embodiment is different from Embodiment 1 in that the molar ratio of β-mercaptoethanol to p-nitrohalobenzene in step 1 is 1.4:1. Others are the same as in the first embodiment.
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