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Method for preparing inorganic nano microcapsule by one-step method

A technology of inorganic nano and microcapsules, which is applied in the preparation of microcapsule preparations and microspheres, and achieves the effect of simple preparation process

Inactive Publication Date: 2008-09-10
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the basis of this method, the present invention will prepare inorganic nano-microcapsules by one-step method, and there is no report of utilizing this method to synthesize inorganic nano-microcapsules

Method used

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  • Method for preparing inorganic nano microcapsule by one-step method
  • Method for preparing inorganic nano microcapsule by one-step method
  • Method for preparing inorganic nano microcapsule by one-step method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 0.5 g of emulsifier sodium lauryl sulfate and 10 g of pH buffer sodium bicarbonate, and add them into 1000 g of water to obtain an emulsifier solution with a pH value of 8.5. Mix 9 g of octane, 0.42 g of hexadecane, and 2.5 g of tetraethyl orthosilicate, add it to the above-mentioned emulsifier aqueous solution, and disperse the above-mentioned mixed liquid with ultrasonic waves to obtain a stable emulsion, and use a dynamic light scattering particle size analyzer to measure the initial The size of the emulsion: the Z average droplet diameter is 80nm; the temperature is adjusted to 80°C, and the reaction is carried out for 3 hours. The particle size was measured with a dynamic light scattering particle size analyzer: the Z-average particle size was 85nm. Observing its morphology with a transmission electron microscope, it is a capsule with a hollow structure.

Embodiment 2

[0046] Weigh 37.5 g of the emulsifier cetyltrimethylammonium bromide, 1 g each of the pH buffering agents sodium dihydrogen phosphate and diammonium hydrogen phosphate, and add them to 1000 g of water to obtain an emulsifier solution with a pH value of 7. Mix 500g of octane, 50g of dodecyl alcohol, and 250g of methyl orthosilicate, add it to the mixed aqueous solution of the above-mentioned emulsifier and pH buffer, and disperse the above-mentioned mixed solution with ultrasonic waves to obtain a stable emulsion. The size of the initial emulsion was measured by a diameter meter: the Z-average droplet diameter was 168nm; the temperature was adjusted to 30°C, and the reaction was carried out for 5 days. The particle size was measured with a dynamic light scattering particle size analyzer: the Z-average particle size was 186 nm. Observing its morphology with a transmission electron microscope, it is a capsule with a hollow structure.

Embodiment 3

[0048] Weigh 15 g of dodecyl dimethyl propylamine sulfonic acid, 10 g of ammonia water as a pH buffer agent, and add them into 1000 g of water to obtain an emulsifier solution with a pH value of 10. Mix 25g of pentane, 6.25g of cetyl alcohol, and 500g of tetraethyl orthosilicate, add it to the above-mentioned aqueous solution containing emulsifier, and disperse the above-mentioned mixed solution with ultrasonic waves to obtain a stable emulsion, which is measured by a dynamic light scattering particle size analyzer The size of the initial emulsion: the Z-average droplet diameter is 108nm; the temperature is adjusted to 30°C, and the reaction is carried out for 2 days. The particle size was measured with a dynamic light scattering particle size analyzer: the Z-average particle size was 132nm. Observing its morphology with a transmission electron microscope, it is a microcapsule with a hollow structure.

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Abstract

The invention relates to a method for preparing a nanometer microcapsule and aims at providing a method for preparing an inorganic nanometer microcapsule by one step. The method includes that an emulsification agent and a PH regulator are dissolved into water; a monomer, a small molecular hydrocarbon template compound and a co-stabilizer are mixed and added into the mixed solution obtained above, and then ultrasonic dispersion is carried out to obtain a stable miniemulsion; the temperature of the obtained miniemulsion is adjusted to 30 to 80 DEG C; the inorganic nanometer microcapsule with an inorganic compound as a shell layer and the small molecular hydrocarbon as a core is obtained after reaction for 3 hours to 5 days. The method has simple preparing process and can stably obtain the inorganic nanometer microcapsule which has high thermal, chemical and mechanical stabilities; simultaneously the porous structure of the shell layer is more beneficial to the substance exchange between the covered object and the outside environment; besides, the size of the microcapsule and the thickness of the shell layer can be conveniently realized by adjusting the proportion of the monomer and the small molecular hydrocarbon, the water-oil ratio and the categories and concentration of the emulsification agent when the invention is used for preparing the microcapsule.

Description

technical field [0001] The invention relates to a method for preparing nanometer microcapsules, in particular to a method for preparing inorganic nanometer microcapsules in one step. Background technique [0002] Hollow materials can be used for drug delivery and slow (controlled) release, biology, coatings, catalysis and nanoreactors because they can be coated with various active substances, including drugs, catalysts, enzymes, dyes, and even macromolecular DNA. field has attracted widespread attention. The shell material of nano-microcapsules can be polymer, metal, carbon, inorganic or organic-inorganic hybrid material, etc. Inorganic materials have high thermal, chemical and mechanical stability, and the porous structure of the shell of inorganic nano-microcapsules can ensure the material transfer between the coated compound and the external environment of the capsule, which has become one of the hot research topics in recent years. [0003] For the preparation of inorg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 单国荣曹志海
Owner ZHEJIANG UNIV
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