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Three-dimensional porous tissue engineering bracket material, preparation and application thereof

A tissue engineering scaffold, three-dimensional porous technology, applied in medical science, prosthesis, bone implants, etc., to achieve the effects of stable structure, uniform pore structure and simple preparation process

Inactive Publication Date: 2008-09-17
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to provide a three-dimensional porous tissue engineering scaffold material, its preparation and application, the method combines the advantages of existing biological materials, overcomes the shortcomings of single material performance, and the prepared tissue engineering scaffold material has good biocompatibility It can be used as bone or cartilage tissue defect repair materials and cell scaffold materials for in vitro tissue culture to meet the needs of the development of a new generation of biomaterials.

Method used

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  • Three-dimensional porous tissue engineering bracket material, preparation and application thereof

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Experimental program
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Effect test

Embodiment 1

[0027] The high polymer PBS with a molecular weight of 40,000 and a melting point of 115°C, and the high polymer PCL with a molecular weight of 80,000 and a melting point of 63°C were completely dissolved in chloroform at 25°C, and stirred evenly to make a mass percentage concentration For a 20% blend solution, uniformly place sodium chloride with a diameter of 50-200 μm in the mold, pour the PBS / PCL blend solution until it just submerges the porogen in the mold, and place the bracket material in a fume hood for 24 hours, until the solvent was completely volatilized, immersed in deionized water for 4 days to leach the sodium chloride particles, during which the water was replaced every 6 hours, and vacuum-dried to obtain a three-dimensional porous PBS / PCL scaffold with a sponge structure. The material has a pore size of 10-200 μm measured by a scanning electron microscope, a porosity of 85% measured by a liquid displacement method, a degree of pore penetration of more than 90%,...

Embodiment 2

[0029] The high polymer PBS with a molecular weight of 80,000 and a melting point of 115°C, and the high polymer PCL with a molecular weight of 100,000 and a melting point of 63°C were completely dissolved in chloroform at 25°C, and stirred evenly to make a mass percentage concentration 10% blend solution, uniformly place sodium chloride with a diameter of 300-500 μm in the mold, pour PBS / PCL blend solution until just submerged in the porogen in the mold, place the bracket material in a fume hood for 24 hours, until the solvent was completely volatilized, immersed in deionized water for 4 days to leach the sodium chloride particles, during which the water was replaced every 6 hours, and vacuum-dried to obtain a three-dimensional porous PBS / PCL scaffold with a sponge structure. The material has a pore diameter of 10-500 μm measured by a scanning electron microscope, a porosity of 89% measured by a liquid displacement method, a degree of pore penetration of more than 90%, an appr...

Embodiment 3

[0031] The high polymer PBS with a molecular weight of 100,000 and a melting point of 118°C, and the high polymer PCL with a molecular weight of 150,000 and a melting point of 64°C were completely dissolved in chloroform at 30°C and stirred evenly to make a mass percentage concentration 6% blend solution, uniformly place sodium chloride with a diameter of 400-500 μm in the mold, pour PBS / PCL blend solution until just submerged in the porogen in the mold, place the bracket material in a fume hood for 24 hours, until the solvent was completely volatilized, immersed in deionized water for 4 days to leach the sodium chloride particles, during which the water was replaced every 6 hours, and vacuum-dried to obtain a three-dimensional porous PBS / PCL scaffold with a sponge structure. The pore diameter of the material measured by the scanning electron microscope is 10-500 μm, the porosity measured by the liquid displacement method is 83%, the degree of pore penetration reaches more than...

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Abstract

The invention relates to three-dimensional porous engineering support material, comprising poly butylene succinate PBS and polycaprolactone PCL, wherein, the weight proportion is that the poly butylene succinate is 90 to 10 shares and the polycaprolactone is 10 to 90 shares. The invention also relates the preparation of the material, which is characterized in that the pore-foaming agent is arranged in a mold evenly and then the PBS / PLC blending chloroform solution is poured in; the support rudiment is put in a hood for 24 hours before immersing deionized water for 2 to 4 days; the PBS / PLC support material can be obtained after drying in vacuum. The invention relates to application of the material also, which mains that the material can be used as supports of bone or cartilage tissue engineered cells for repairing and restructuring the bone or cartilage tissue organ. The support material has the advantages of even inner hole structure and good communication between the holes, namely the hold diameter is between 10 to 500Mum and the porosity is between 70 to 91 percent, as well as the advantages of steady structure and easy preparation technology.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffold materials and preparation, in particular to a tissue engineering scaffold material using polybutylene succinate / polycaprolactone as a raw material and a tissue engineering scaffold prepared by solvent casting / particle leaching method. Background technique [0002] In daily life, the loss or failure of human tissues and organs is very common, which poses a serious threat to people's health and life. For a long time, human beings have been exploring and researching the use of materials and biotechnology to improve their own health. Traditional treatment methods include tissue and organ transplantation, surgical reconstruction, drug therapy, treatment with artificial substitutes and mechanical devices, etc., but these methods all have their obvious shortcomings. In the 1990s, with the development of cell biology, molecular biology, material science and related physical and chemical discip...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/56A61F2/28
Inventor 杨庆陈思诗郯志清沈新元彭兰兰
Owner DONGHUA UNIV
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