Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

A transdermal and compound technology is applied in the field of traditional Chinese medicine for the treatment of dysmenorrhea, and achieves the effects of long medicinal effect, high content of active ingredients and clear medicinal effect.

Inactive Publication Date: 2008-09-24
TIANJIN ZHONGBAO PHARMACY
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has no direct inhibitory effect on the cerebral cortex, but it can block the ascending activation system and descending inhibitory function of the brainstem reticular structure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation method of the traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea of ​​the present invention comprises the following steps:

[0039] (1) CO was used for the powder or coarse powder of Chinese herbal medicines Angelica and Turmeric respectively. 2 Supercritical extraction device, under the conditions of pressure 30MPa and temperature 50-55°C, extract for 3-4 hours to obtain angelica extract and turmeric extract respectively;

[0040] (2) The traditional ethanol extraction method is used for the material powder or coarse powder of the Chinese medicinal material Corydalis Corydalis to obtain Corydalis Corydalis extractum extract;

[0041] (3) Take angelica extract, turmeric extract, and β-cyclodextrin inclusion compound in proportion, and disperse them strongly through a nano-microemulsion disperser to control the microemulsion particles at the nanoscale to prepare a microemulsion dispersion;

[0042] (4) Add transd...

Embodiment 1

[0049] formula:

[0050] Angelica CO 2 Supercritical Extraction Oil 6g

[0051] Turmeric CO 2 Supercritical Extraction Oil 3g

[0052] Corydalis extract 16.5g

[0053] Transdermal absorption enhancer laurocapram Azone 3g

[0054] β-cyclodextrin inclusion complex 10g

[0055] Medical pressure sensitive adhesive 300g

[0056] Makes 350 stickers

Embodiment 2

[0058] formula:

[0059] Angelica CO 2 Supercritical Extraction Oil 1.5g

[0060] Turmeric CO 2 Supercritical Extraction Oil 3g

[0061] Corydalis extract 12g

[0062] Transdermal absorption enhancer laurocapram Azone 1.5g

[0063] β-cyclodextrin inclusion complex 9g

[0064] Medical pressure sensitive adhesive 300g

[0065] Makes 350 stickers

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Chinese traditional medicine compound trans-dermal absorption plaster for treating dysmenorrhea and a preparation method thereof. The plaster is prepared with the following materials by weight ratios: 0.5-3 shares of angelica extract, which is extracted from angelica by carbon dioxide supercritical extraction; 4-6 shares of fumitory extract, which is extracted from fumitory by traditional extraction method; 1-3 shares of turmeric extract, which is extracted from Chinese traditional medicinal materials by carbon dioxide supercritical extraction; 0.5-2 shares of trans-dermal accelerant; and 100-150 shares of pressure-sensitive adhesive. The materials are dispersed by nano-microemulsion dispersing machine intensively, and the particle diameter of the microemulsion is limited in nano-grade. The trans-dermal absorption preparation of the invention enters into the Subcutaneous capillary through skin cell gaps, and gets to the focus along with the blood circulation; the biological availability is improved by more than 10 times higher than the equivalent products, the curative effect is improved notably, the usage is convenient, and the adaptability of the sufferer is improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating dysmenorrhea, in particular to a traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or percutaneous absorption patch refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. The characteristic of the transdermal absorption patch is that the transdermal drug delivery system can avoid the first-pass effect of the liver and the inactivation of the drug in the gastrointestinal tract. Effective blood concentration or physiological effects, avoiding the peak and valley phenomenon of blood concentration caused by oral administration. Reduce toxic and side effects, reduce a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/9066A61K9/70A61K47/40A61P15/00A61P29/02
Inventor 高惠明杨吉田
Owner TIANJIN ZHONGBAO PHARMACY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com