Medicament composition

Abstract

The invention discloses a medicine composition which is characterized in that: the medicine composition is determined through a dose-response relationship experiment, a harmacodynamic verification experiment, a pharmacokinetic experiment and a toxicological experiment, wherein, the medicine composition comprises the following compositions in portion by weight: 1 to 10 portions of salvianolic acid A from salvia miltiorrhiza, and 1 to 50 portions of blood-quickening and stasis-dispelling effective constituents of traditional Chinese medicines; or preferable 1 to 5 portions of the salvianolic acid A from salvia miltiorrhiza, and 20 to 50 portions of the blood-quickening and stasis-dispelling effective compositions of the traditional Chinese medicines; or preferable 6 to 10 portions of the salvianolic acid A from salvia miltiorrhiza, and 1 to 19 portions of the blood-quickening and stasis-dispelling effective compositions of the traditional Chinese medicines. As shown in a pharmacologic experiment of the composition, the medicine composition has good pharmacologic effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition comprising salvianolic acid A and active ingredients of traditional Chinese medicines for promoting blood circulation and removing blood stasis; [0002] The active ingredients of traditional Chinese medicine for promoting blood circulation and removing blood stasis in this application refer to one or more of the following: notoginseng saponin, ligustrazine, angelica ligustilide or ferulic acid, paeoniflorin, timosaponin, gypenoside, muscone , eleutheroside, balsamic volatile oil, puerarin, ginkgolide, ginkgo flavonoids, jujube flavonoids, jujubeolin, amygdalin, paeonol, American ginsenoside, aescin or aescin sodium, epimedium Huoside; [0003] The active ingredients of the traditional Chinese medicine for promoting blood circulation and removing blood stasis are prepared according to existing literature or patented methods. Background technique ...

AI Technical Summary

Problems solved by technology

[0005] Salvia miltiorrhiza is the root and rhizome of Salvia miltiorrhiza Bge. It is slightly cold in nature and bitter in taste. Chest and abdomen tingling pain, heat arthralgia pain, sore swelling and pain, hepatosplenomegaly, angina pectoris and other symptoms are commonly used medicinal flavors in traditional Chinese medicine for promoting blood circulation and removing blood stasis; studies have shown that the main active ingredient in Salvia miltiorrhiza is salvianolic acid A (Du Guanhua [Basic Medicine] and Clinical, 2000, 20(5): 10-14], Hu Yiyang [Acta Pharmacology of Traditional Chinese Medicine, 1997, 18(5): 478-480]), but because of the defects of the existing technology, it is impossible to obtain batch-level salvianolic acid A, mainly because the content of salvianolic acid A in Salvia miltiorrhiza is very low, only about 5 / 10,000. Even if it is extracted through a series of processes, only trace amounts of salvianolic acid A can be obtained. Therefore, it is impossible to extract Salvianolic acid A and other active parts or active ingredients of traditional Chinese medicines have been researched on the formulation of prescriptions. Although Danshen Salvianolic Acid has participated in the research on the compatibility of other traditional Chinese medicines, the main research focus is still on the formulation of salvianolic acid B. This kind of research has a certain effect, but the most effective ingredients in traditional Chinese medicine have not been studied, so it is impossible to achieve a superior effect;

[0006] Check the literature and patents, but there is no report on the study of formula formulation of salvianolic acid A

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