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Xinshuning tablets quality control method

A quality control method, the technology of Xinshuning Tablets, is applied in the field of quality control of Xinshuning Tablets, which can solve the problems of less identification of medicinal flavors and inability to effectively control product quality, so as to ensure safety and effectiveness, improve specificity and stabilize quality sexual effect

Inactive Publication Date: 2008-11-19
GUANGZHOU BAIYUNSHAN QIXING PHARMA
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Problems solved by technology

The identification method of this standard is only the HPLC qualitative identification method of puerarin, which has little identification of medicinal taste, and there is no method for determining the content of active ingredients, which cannot effectively control product quality.

Method used

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with embodiment.

[0027] Get the perhexiline tablet that the batch number produced by the applicant is 5001.

[0028] [Identification] (1) Take 2 tablets of this product, remove the sugar coating, grind finely, add 10ml of methanol, ultrasonically treat for 15 minutes, filter, and the filtrate is used as the test solution. Another 1 g of ginkgo biloba reference drug was taken, and the reference drug solution was prepared in the same way. Test according to thin-layer chromatography (Appendix VI B of Chinese Pharmacopoeia 2005 Edition), draw 5 μl of each of the above two solutions, and place them on the same silica gel G thin-layer plate containing 4% sodium acetate respectively, and use ethyl acetate-butanone -Formic acid-water (5:3:1:1) was used as the developer, developed, taken out, dried in the air, and inspected under ultraviolet light (365nm). In the chromatogram of the test product, there are ...

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Abstract

The invention provides a method used for controlling the quality of perhexiline tablets, which comprises the steps of: (1) discriminating an effective ingredient, namely total flavonol glycoside, from ginko leaves contained in the perhexiline tablets by adopting the thin-layer chromatography; (2) discriminating an effective ingredient, namely terpene lactone, from ginkgo leaves contained in the perhexiline tablets by adopting the thin-layer chromatography; (3) discriminating an effective ingredient, namely hydrochloric acid stachydrine, from motherwort contained in the perhexiline tablets by adopting the thin-layer chromatography; (4) discriminating herba siegesbeckiae contained in the perhexiline tablets by adopting the thin-layer chromatography; (5) measuring the content of puerarin contained in the perhexiline tablets by adopting the high efficiency liquid chromatography. The method overcomes the defects of the HPLC qualitative discrimination method of puerarin and the content measuring method which can only discriminate less ingredients and can not discriminate active ingredients in the prior discrimination method. The method in the invention improves the specialty of the quality control method of perhexiline tablets and the quality stability, and ensures safe and effective use of medicaments for users.

Description

technical field [0001] The invention relates to a quality control method of Chinese patent medicines, in particular to a quality control method of Xinshuning Tablets. Background technique [0002] Xinshuning Tablet is a Chinese patent medicine for promoting blood circulation and removing blood stasis. It has been used in my country for many years. It is clinically used for chest pain, coronary heart disease, angina pectoris, coronary insufficiency, and arteriosclerosis with the above symptoms. Xinshuning Tablets are prepared from holly holly, ginkgo leaves, pueraria lobata, motherwort, scutellaria, and persimmon leaves according to the conventional process of Chinese patent medicine tablets. The standard is recorded in the standard of the Ministry of Health of the People's Republic of China Drug Standards Chinese Medicine Prescriptions Volume 17, standard number WS 3 -B-3153-98. The identification method of this standard only has the qualitative identification method of HP...

Claims

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Application Information

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IPC IPC(8): A61K36/533A61K9/20G01N30/90G01N30/02A61P9/10
Inventor 黄夏敏冯倩玲陈英麦燕霞
Owner GUANGZHOU BAIYUNSHAN QIXING PHARMA
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