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Compound amino acid injection for treating hepatic encephalopathy

A compound amino acid and hepatic encephalopathy technology, which is applied in the field of compound amino acid injection for the treatment of hepatic encephalopathy, to achieve the effect of reducing blood ammonia concentration, improving metabolism, and high blood ammonia concentration drop rate

Active Publication Date: 2010-12-08
MITSUBISHI PHARMA GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, with the deepening of clinical application research, researchers have a better understanding of the cause of hepatic encephalopathy. In addition to the false neurotransmitter theory proposed by Fischer, high blood ammonia concentration is also the main cause of hepatic encephalopathy. , while previous products only focused on improving the Fischer ratio of compound amino acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Dissolve the following components in distilled water for injection according to the following parts by weight, adjust the pH value of the amino acid solution to neutral, put the solution into a bottle or plastic bag after sterilization and filtration, fill it with nitrogen and seal it, and heat it out according to the conventional method Bacteria, make the present embodiment injection.

[0092] L-isoleucine 12.12

[0093] L—Leucine 12.45

[0094] L-valine 11.73

[0095] L-lysine acetate 5.20

[0096] L-Methionine 0.58

[0097] L-phenylalanine 0.39

[0098] L-threonine 2.82

[0099] L-tryptophan 0.92

[0100] L-alanine 11.07

[0101] L-arginine 20.26

[0102] L-aspartic acid 0.26

[0103] L—histidine 4.08

[0104] L-proline 6.98

[0105] L-serine 3.42

[0106] L-tyrosine 0.52

[0107] Glycine 7.11

[0108] L-cysteine ​​0.32

[0109] Sodium bisulfite 0.32

Embodiment 2

[0111] Prepare the following components and parts by weight of the injection according to the method of Example 1.

[0112] L-isoleucine 11.95

[0113] L—leucine 14.50

[0114] L-valine 11.50

[0115] L-lysine hydrochloride 4.60

[0116] L-Methionine 0.60

[0117] L-phenylalanine 0.00

[0118] L-threonine 2.80

[0119] L-tryptophan 0.85

[0120] L-alanine 11.00

[0121] L-arginine 18.50

[0122] L-aspartic acid 0.10

[0123] L—histidine 3.95

[0124] L-proline 7.50

[0125] L-serine 3.40

[0126] L-tyrosine 0.65

[0127] Glycine 7.00

[0128] L-cysteine ​​0.20

[0129] Sodium bisulfite 0.20

Embodiment 3

[0131] Prepare the following components and parts by weight of the injection according to the method of Example 1.

[0132] L-isoleucine 13.89

[0133] L-leucine 12.00

[0134] L-valine 13.00

[0135] L-lysine acetate 6.20

[0136] L-Methionine 0.30

[0137] L-phenylalanine 0.40

[0138] L-threonine 2.90

[0139] L-tryptophan 0.95

[0140] L-alanine 11.00

[0141] L-arginine 18.50

[0142] L—Aspartic acid 0.30

[0143] L—histidine 4.95

[0144] L-proline 6.50

[0145] L-serine 3.60

[0146] L-tyrosine 0.25

[0147] Glycine 7.00

[0148] L-cysteine ​​0.40

[0149] Sodium bisulfite 0.40

[0150] The beneficial effect of the injection of the present invention will be further elaborated below through specific clinical experiments.

[0151] 1. Controlled clinical trials

[0152] (1) Research methods

[0153] 1. Research object:

[0154] Patients with chronic hepatic insufficiency with hepatic encephalopathy (≤grade II or subclinical) and / or hyperammonemia (blood am...

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Abstract

The present invention provides a compound amino acid injection with high Fischer rate for curing hepatic encephalopathy, which can rapidly lower the blood ammonia density. The present invention increases the weight parts of three branched amino acid and arginine and reduces the weight parts of sulfur amino acid and ammonia amino acid. The injection provided by the present invention is more conducive to regulating the plasma amino acid spectrum to be normal, increases the density of arginine, stably lowers the level of blood ammonia of the patient and improves the immunity of the organism, thus achieving the aim of rapidly improving the symptom of hepatic encephalopathy and replenishing nutrition. Therefore, the injection of the present invention has higher curing effect in improving hepatic encephalopathy.

Description

technical field [0001] The invention relates to a compound amino acid, in particular to a compound amino acid injection for treating hepatic encephalopathy. Background technique [0002] Hepatic encephalopathy (hepatic encephalopathy HE) used to be called hepatic coma. It is a syndrome caused by severe liver disease, based on metabolic disorders and dysfunction of the central nervous system. Its main clinical manifestations are disturbance of consciousness, abnormal behavior and coma. Most hepatic encephalopathy is caused by various cirrhosis of the liver, and it can also be caused by portosystemic shunt surgery to improve portal hypertension. The pathogenesis has not been fully understood so far. There are many theories at present, including the theory of ammonia poisoning and the theory of amino acid metabolism imbalance, which are the most researched and most reliable. [0003] According to the amino acid metabolism imbalance theory, various amino acid preparations for t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/04A61P1/16A61P25/00A61K31/198A61K31/401A61K31/405A61K31/4172
Inventor 古川正人
Owner MITSUBISHI PHARMA GUANGZHOU
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