Oral nano raw baizhu colon tablet and preparation method thereof

A technique for producing Atractylodes macrocephala and colon, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It can solve problems such as inconvenience in use, achieve convenient use, reduce adverse drug reactions, and distribute evenly. Effect

Inactive Publication Date: 2011-03-23
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that the existing common water decoction of Shengbaizhu begins to be released and absorbed from the upper gastrointestinal tract and is inconvenient to use, the present invention provides an oral nano-sized Shengbaizhu colon tablet, which significantly improves the curative effect

Method used

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  • Oral nano raw baizhu colon tablet and preparation method thereof
  • Oral nano raw baizhu colon tablet and preparation method thereof
  • Oral nano raw baizhu colon tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Preparation of Oral Nano-sized Atractylodes Atractylodes Colon Tablets

[0025] (1) Preparation of Nano-life Atractylodes Rhizome Powder

[0026] After the raw Atractylodes macrocephala medicinal material is dried, it is pulverized by a nano pulverizer to obtain fine powder through a sieve of 400 mesh to 1200 mesh.

[0027] Preparation of raw Atractylodes macrocephala polysaccharide liquid: Take 400g of Atractylodes rhizome raw medicine pieces, add 4-8 times the amount of 75% ethanol, reflux 1-2 times, 2 hours each time, filter; add 8 times the amount of water to decoct 3 times, 1.5 hours each time , combined water decoction, concentrated to 400ml (equivalent to crude drug 1g / ml), let stand, centrifuged; add ethanol to the supernatant to adjust to 75%, let stand; suction filter, dissolve the precipitate with distilled water, centrifuge, supernatant Add ethanol to adjust to 75%, let stand, filter with suction, wash the precipitate repeatedly with absolute ...

Embodiment 2

[0050] Embodiment 2: Pharmacodynamics experiment of the present invention

[0051] 1. Materials

[0052] Raw Atractylodes macrocephala was purchased from Bengbu Medicinal Materials Company in Anhui, and nano powder was prepared by CW-15 nano pulverizer produced by Yantai Huibao Equipment Manufacturing Co., Ltd., and processed by the production equipment of Yangzhou Pharmaceutical Factory of Jiangsu Lianhuan Pharmaceutical Co., Ltd.: ① Pressing Make 0.1g plain tablets and coat with colon coat; ②Extrude and spheronize to prepare pellets and coat with colon coat. Rabbits and mice were provided by the Experimental Animal Center of Yangzhou University.

[0053] 2. Methods and Results

[0054] 2.1 The effect of Shengbaizhu colon pellets on the advancement speed of barium meal and Indian ink in the small intestine of mice

[0055] 2.1.1 The effect of Shengbaizhu colon pellets on the advancement speed of barium meal in the small intestine of mice

[0056] Take 40 ICR mice weighing...

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Abstract

The invention relates to an oral nanometer crude Atractylodes macrocephala tablet for treating colonic diseases and a preparation method thereof, belonging to the technical field of medicaments. The oral nanometer crude Atractylodes macrocephala tablet is made with crude Atractylodes macrocephala nanometer powder and crude Atractylodes macrocephala polysaccharide extractive solution as a raw material and pectic calcium as a main coating material. The preparation method comprises the steps of: drying crude Atractylodes macrocephala, and pulverizing with a manometer pulverizer to obtain 400-1,200 mesh power; extracting to obtain crude Atractylodes macrocephala extractive solution as a wetting agent; reacting pectin and calcium chloride to obtain pectic calcium suspension for coating; and tabletting with the crude Atractylodes macrocephala nanometer powder and the crude Atractylodes macrocephala polysaccharide extractive solution, and coating. The inventive oral nanometer crude Atractylodes macrocephala tablet can safely pass through the upper digestive tract and release medicinal components after reaching the colon; and has the advantages of low oral dosage, reduced adverse effects,convenient administration, etc.

Description

technical field [0001] The invention relates to an orally administered nano-sized Baizhu colon tablet for clinical application and a preparation method thereof, belonging to the field of medical technology research. Background technique [0002] With the aging of the population, changes in eating habits, and the influence of social and psychological factors, constipation has become one of the important factors that plague the quality of life of modern people. Chronic constipation is a common clinical symptom caused by a variety of etiologies. Functional slow transit constipation mainly manifests as weakened or (and) disturbance of colon motility, slowed fecal propulsion, and slow emptying. The disease can occur at any age, but it is mainly the elderly and women. The general course of the disease is longer. At present, there is no specific drug for the treatment of chronic functional constipation at home and abroad. The occurrence and development of the disease. [0003] I...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/284A61K9/36A61K47/36A61P1/10
Inventor 卜平胡荣卜乐
Owner YANGZHOU UNIV
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