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Method for processing surface functionalization and modification of biological medical titanium alloy

A biomedical, surface functional technology, applied in pharmaceutical formulations, pharmaceutical sciences, dentistry, etc., can solve the problems of lack of active functional groups, difficult to combine with macromolecular drugs, etc., and achieve the effects of fast reaction, good biological activity and simple operation.

Active Publication Date: 2009-01-21
XIAN CONTINENTAL BIOMATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as mentioned above, titanium and titanium alloy materials due to surface TiO 2 The existence of the film is biologically inert, lacking active functional groups, and it is difficult for macromolecular drugs to bind to the surface of the material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The biomedical pure titanium sample is first treated in a mixed solution of hydrogen peroxide and hydrochloric acid with a volume percentage of 1:1 at 70°C. The substance concentration (mol / L) of the hydrochloric acid solution is: 12mol / L, and the volume concentration of the hydrogen peroxide solution is is 30%, while adding a small amount of FeCl to the mixed solution 2 Ferrous salt, Fe 2+ The concentration of the substance is 0.002mol / L~0.008mol / L, and hydroxyl groups are introduced on the surface of the biomedical pure titanium sample; then the biomedical pure titanium is placed in a reactor with a stirrer under a nitrogen atmosphere, and then Add a certain amount of deionized water into the kettle, start the stirrer, and slowly add non-ionic polyacrylamide with a relative molecular weight of 8 to 10 million, so that the mass percentage concentration of the polyacrylamide solution is about 2%, and the viscosity is 3Pa·s After the polyacrylamide is dissolved, add a c...

Embodiment 2

[0026] The biomedical titanium alloy sample is first treated in a hydrogen peroxide and hydrochloric acid solution with a volume percentage of 1:1 at 70°C. The substance concentration (mol / L) of the hydrochloric acid solution is: 12mol / L, and the volume concentration of the hydrogen peroxide solution is : 30%, while adding a small amount of FeSO to the solution 4 , Fe 2+The concentration of the substance is 0.006mol / L, and hydroxyl groups are introduced on the surface of the sample; then the titanium alloy sample is placed in a reaction kettle with a stirrer under a nitrogen atmosphere. Then add a certain amount of deionized water into the reaction kettle, start the agitator, and slowly add non-ionic polyacrylamide with a relative molecular weight of 8 to 10 million, so that the mass percentage concentration of the polyacrylamide solution is about 2%, and the viscosity is 3Pa. About s, ventilate and heat up to 55°C. After the polyacrylamide dissolves, add a certain amount of ...

Embodiment 3

[0028] The biomedical pure titanium sample is first treated in hydrogen peroxide and hydrochloric acid solution with a volume percentage of 1:1 at 70°C. The substance concentration (mol / L) of the hydrochloric acid solution is: 12mol / L, and the volume concentration of the hydrogen peroxide solution is 30%, while adding a small amount of Fe to the solution 2+ , Fe 2+ The amount of the substance is 0.002mol / L~0.008mol / L, and hydroxyl groups are introduced on the surface of the sample; then the titanium alloy sample is placed in a reactor with a stirrer under a nitrogen atmosphere, and then a certain amount of deionized water, start the stirrer, and slowly add non-ionic polyacrylamide with a relative molecular weight of 9 million, so that the mass percent concentration of the polyacrylamide solution is 2%, and the viscosity is 3Pa·s. Ventilate and heat up to 55°C. After the polyacrylamide is dissolved, add a certain amount of NaOH to make the pH reach 10-11, react for 6 hours, an...

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Abstract

The invention discloses a processing method for functionalization modification on biomedical titanium alloy surface, and active hydroxide radical, amidogen and carboxyl are introduced to the medical titanium alloy surface by the treatment of hydroxylation solution and amidogen solution. The process is as follows: the biomedical titanium alloy sample is firstly treated in hydrogen peroxide containing little Fe<2+> and hydrochloric acid solution, then is placed into polyacrylamide solution in nitrogen atmosphere, a suitable amount of cerous nitrate salt is added, hypochlorite solution is added after reaction for a time, the reaction is continued, and the sample is rinsed and air-dried in NaOH solution and hot water sequentially after cooling. Compared with untreated titanium alloy, the titanium alloy after the treatment in the invention keeps excellent mechanical property and biocompatibility of the matrix, at the same time, active function group is introduced to the alloy surface, thus leading to good biological activity, the active function group covalent linkage is connected with biological functional macro molecules, thus further improving the histocompatibility and blood compatibility of implanted or interventional material.

Description

technical field [0001] The invention relates to a treatment method for functional modification of the surface of a biomedical titanium alloy. The method uses a hydroxylation solution and an amination solution to introduce active hydroxyl groups, amino groups and carboxyl groups on the surface of the medical titanium alloy for drug-carrying blood vessels. Surface modification of human implants and interventional medical devices such as internal stents and dental implants. Background technique [0002] Under normal circumstances, medical titanium and titanium alloy materials used for implantation in the human body will quickly grow a layer of TiO in situ on the surface in the air or in contact with oxygen. 2 Thin film, the film is generally tens of nanometers thick, which is one of the main reasons why titanium and titanium alloy materials have good biocompatibility. But at the same time TiO 2 Film is an inert material with poor cell adhesion, and it is not easy to quickly f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61K6/04
Inventor 余森于振涛牛金龙韩建业贺新杰麻西群皇甫强张亚峰袁思波
Owner XIAN CONTINENTAL BIOMATERIALS CO LTD
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