Preparation method of drug-carrying hydroxylapatite microspheres and bone cement composite porous microspheres
A technology of hydroxyapatite and nano-hydroxyapatite, which is applied in the fields of phosphorus compounds, chemical instruments and methods, and medical science, and can solve problems such as the influence of in-situ drug loading, difficult drug loading, and unstable drug release. , to achieve the effect of controlling drug release rate, easy regulation of microsphere size, and adjustable drug loading
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Embodiment 1
[0018] Step 1: Synthesis of nano-hydroxyapatite
[0019] Accurately weigh 23.66g Ca (NO 3 ) 2 4H 2 O and 4.26g P 2 o 5 , the corresponding Ca(NO 3 ) 2 4H 2 O and P 2 o 5 Dissolve in 300ml and 125ml absolute ethanol respectively, prepare the Ca(NO 3 ) 2 and P 2 o 5 solution. With 100ml of absolute ethanol as the base solution, P 2 o 5 and Ca(NO 3 ) 2 The solution was dropped into the base liquid at the same time, and stirred continuously to obtain a transparent solution, and left to stand for 24 hours to obtain a milky white colloidal system. It was then dried in an oven at 70°C to obtain a white powder. Then put the obtained white powder into a calcination furnace and heat it to 300°C to obtain hydroxyapatite with low crystallinity, and calcine at 600°C to obtain hydroxyapatite with complete crystallization, and the calcined powder has good dispersibility .
[0020] Step two:
[0021] Accurately weigh 171.1 grams of calcium hydrogen phosphate dihydrate (CaHP...
Embodiment 2
[0027] Step 1 and Step 2 are the same as in Example 1.
[0028] Step 3: Preparation of porous hydroxyapatite microspheres
[0029] Dissolve 4.5g of gelatin in 30ml of deionized water at a temperature of 40°C and stir for 1 hour to obtain a gelatin solution with a concentration of 0.15g / ml; accurately weigh 9 grams of nano-hydroxyapatite prepared in step 1 of Example 1 Stone (HAp) powder was added to the above gelatin solution to prepare a mixed suspension of gelatin / HAp with a concentration of 0.3 g / ml. The gelatin / HAp mixed suspension was added into the soybean oil at a stirring speed of 700 rpm, and the oil temperature was kept at 15°C. After stirring for 1 h, the microspheres were left to settle at the bottom of the oil layer for 24 h; the upper layer of vegetable oil was poured off, and the prepared microspheres were washed with acetone and ethanol respectively, and dried naturally in the air to obtain composite microspheres of gelatin / HA; Sintering is carried out at 110...
Embodiment 3
[0033] Step 1 and Step 2 are the same as in Example 1.
[0034] Step 3: Preparation of porous hydroxyapatite microspheres
[0035] Dissolve 8 g of gelatin in 40 ml of deionized water at a temperature of 40° C. and stir for 1 hour to obtain a gelatin solution with a concentration of 0.2 g / ml; accurately weigh 16 g of nano-hydroxyapatite prepared in Step 1 of Example 1 ( HAp) powder was added to the above gelatin solution to prepare a mixed suspension of gelatin / HAp with a concentration of 0.4 g / ml. The gelatin / HAp mixed suspension was added into the soybean oil at a stirring speed of 700 rpm, and the oil temperature was kept at 15°C. After stirring for 1 h, the microspheres were left to settle for 36 h at the bottom of the oil layer; the upper layer of soybean oil was poured off, and the prepared microspheres were washed with acetone and ethanol respectively, and dried naturally in the air to obtain composite microspheres of gelatin / HA; Sintering is carried out at 1100°C in t...
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