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Self-assembly modified titanium or titanium alloy material from layer to layer as well as preparation method and use thereof

A layer-by-layer self-assembly, titanium alloy technology, applied in the preparation of titanium or titanium alloy materials, in the field of titanium or titanium alloy materials, to achieve good promotion and application value, mild preparation conditions, and good clinical application prospects

Inactive Publication Date: 2009-04-22
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no surface-modified titanium and titanium alloy materials have been successfully applied clinically.

Method used

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  • Self-assembly modified titanium or titanium alloy material from layer to layer as well as preparation method and use thereof
  • Self-assembly modified titanium or titanium alloy material from layer to layer as well as preparation method and use thereof
  • Self-assembly modified titanium or titanium alloy material from layer to layer as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment is a layer-by-layer self-assembled modified titanium film, and its preparation method includes the following steps:

[0032] A, take by weighing chitosan 0.5g, adding concentration is 50mL of acetic acid solution of 10mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 1%;

[0033] b. Weigh 0.5 g of gelatin, add 25 mL of deionized water whose pH value is adjusted to 10 with sodium hydroxide, and dissolve at a temperature of 40° C. to prepare a gelatin solution with a concentration of 2% by mass;

[0034] C, put titanium film in the chitosan solution that step a makes, soak for 10 minutes, take out;

[0035] d. Washing the titanium film treated in step c twice with deionized water, soaking for 2 minutes each time;

[0036] e. Put the titanium film cleaned in step d into the gelatin solution prepared in step b, soak for 20 minutes, and take it out;

[0037] f. Washing the titanium membra...

Embodiment 2

[0040] This embodiment is a layer-by-layer self-assembled modified titanium film, and its preparation method includes the following steps:

[0041] A, take chitosan 1.0g, add concentration and be 50mL of acetic acid solution of 10mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 2%;

[0042] b. Weigh 2.0 g of gelatin, add 25 mL of deionized water adjusted to a pH value of 11 with sodium hydroxide, and dissolve at a temperature of 45° C. to prepare a gelatin solution with a concentration of 8% by mass;

[0043] C, put titanium film in the chitosan solution that step a makes, soak for 20 minutes, take out;

[0044] d. Washing the titanium film treated in step c with deionized water for 3 times, soaking for 1 minute each time;

[0045] e. Put the titanium film cleaned in step d into the gelatin solution prepared in step b, soak for 10 minutes, and take it out;

[0046]f. Washing the titanium film treated in s...

Embodiment 3

[0049] This embodiment is a Ti-6Al-4V titanium alloy modified by layer-by-layer self-assembly, and its preparation method includes the following steps:

[0050] A, take chitosan 1.5g, add concentration and be 50mL of the acetic acid solution of 20mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 3%;

[0051] b. Weigh 1.5 g of gelatin, add 25 mL of deionized water whose pH value is adjusted to 11 with sodium hydroxide, and dissolve at a temperature of 45° C. to prepare a gelatin solution with a concentration of 6% by mass;

[0052] C, put titanium alloy in the chitosan solution that step a makes, soak for 15 minutes, take out;

[0053] d. Wash the titanium alloy processed by step c three times with deionized water, soaking for 1 minute each time;

[0054] e. Put the titanium alloy cleaned in step d into the gelatin solution prepared in step b, soak for 15 minutes, and take it out;

[0055] f, cleaning the t...

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Abstract

The invention discloses a titanium or titanium alloy material for self-assembly decoration layer by layer. The surface of the material is self-assembled with at least five layers of bioactive coats consisting of double-layer chitosan-gelatin. The material has favorable osteoplast compatibility, can promote multiplication and skeleton remolding of osteoplast, shows potential for further developing a novel medical hard tissue implant material, and has favorable clinical application prospect. The titanium or titanium alloy material for surface decoration is prepared by a self-assembly method layer by layer; alternate layers of polycation electrolyte chitosan and polyanion electrolyte gelatin are laminated and assembled on the surface of the titanium or titanium alloy material through electrostatic adsorption action; and the preparation method is simple, can control coating thickness, is not affected by size and shape of the material, is suitable for the materials with complex appearance, has moderate preparation conditions, needs no special equipment, and has low production cost, strong practicability, and better popularization and application values.

Description

technical field [0001] The invention relates to a metal material, in particular to a layer-by-layer self-assembled modified titanium or titanium alloy material, and also relates to a preparation method and application of the modified titanium or titanium alloy material. Background technique [0002] At present, bone defects caused by trauma, fractures, osteoporosis and other diseases are common clinical problems. Every year, millions of hard tissue implants are used for bone fixation or functional tissue replacement around the world. Due to their excellent biocompatibility and comprehensive mechanical properties, titanium and titanium alloys have become the most widely used hard tissue implant materials in clinical practice, and are used to make artificial joints, internal fixation devices and bone reconstruction materials. However, titanium and titanium alloy materials themselves lack biological activity and have no ability to induce osseointegration. Implants made of them ...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06
Inventor 蔡开勇
Owner CHONGQING UNIV
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