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Nonoxinol pellicles film and preparation method and use thereof in preparing contraceptive medicine

A technology of nonoxynol and film preparation, applied in the field of nonoxynol film preparation and preparation thereof, can solve the problems of inability to fertilize eggs, contraceptive effect, inability of sperm to enter the cervix, change the permeability of sperm cells, and the like, and achieve good Biodegradability, significant contraceptive effect, non-immunogenic effect

Inactive Publication Date: 2009-05-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nonoxynol is a nonionic surfactant, 0.2% nonoxynol solution can quickly kill sperm, the film can be quickly dissolved in the deep part of the vagina to play a spermicidal effect, after the vagina is dissolved, it can be combined with sperm cell fat The protein membrane interacts, changes the permeability of sperm cells, kills sperm or makes sperm inactive, so that sperm cannot enter the cervix and cannot fertilize eggs to achieve contraceptive effect

Method used

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  • Nonoxinol pellicles film and preparation method and use thereof in preparing contraceptive medicine
  • Nonoxinol pellicles film and preparation method and use thereof in preparing contraceptive medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Weigh 1g of chitosan hydrochloride, slowly add 25ml of distilled water to chitosan hydrochloride at room temperature, and stir while adding to prevent it from agglomerating until it is evenly stirred and then placed for 30 minutes to fully swell. spare;

[0018] (2) Add 0.4g polyethylene glycol 600 and 0.01g jasmine sesame oil to 0.5g nonoxynol ether and stir evenly;

[0019] (3) Put the chitosan hydrochloride of step (1) into a water bath at 90°C for heating and stirring, then add 0.1 g of polyethylene glycol 600 and 0.005 g of ethyl paraben and continue to stir evenly for later use;

[0020] (4) Slowly pour the film prepared in step (3) into the nonoxynol ether solution of step (2), heat it on a water bath at 80°C and stir evenly, and pour the above-mentioned drug slurry evenly on four pieces Clean and smooth 10cm*20cm glass plate, 800cm film made by hand 2 , The film thickness is controlled at about 43um, put it in a constant temperature blast dryer at 70°C for 10 mi...

Embodiment 2

[0022] (1) Weigh 2g of chitosan hydrochloride and 1g of nonoxynol ether for use; slowly add 45ml of distilled water to chitosan hydrochloride at room temperature, and stir while adding to prevent it from agglomerating until it is evenly stirred. Leave it for 30 minutes to fully swell, and use it for later use;

[0023] (2) Add 1g of propylene glycol and 0.05g of rose sesame oil to 1g of nonoxynol and stir evenly;

[0024] (3) Put the chitosan hydrochloride of step (1) into a 75°C water bath and heat and stir, then add 0.5 g of propylene glycol and 0.005 g of benzoic acid and continue to stir evenly, and set aside;

[0025] (4) Slowly pour the film prepared in step (3) into the nonoxynol ether solution of step (2), heat it on a water bath at 85°C and stir evenly, and pour the above-mentioned drug slurry evenly on four pieces Clean and smooth 10cm*20cm glass plate, 800cm film made by hand 2 , The film thickness is controlled at about 50um, put it in a constant temperature blast drye...

Embodiment 3

[0027] (1) Weigh 1g of chitosan hydrochloride and 0.5g of nonoxynol ether for later use; slowly add 25ml of distilled water to chitosan hydrochloride at room temperature, and stir while adding to prevent it from agglomerating until it is evenly stirred Leave it for 30 minutes to fully swell, and then set aside;

[0028] (2) Add 0.6g triacetin and 0.1g vanillin to 0.5g nonoxynol ether and stir evenly;

[0029] (3) Put the chitosan hydrochloride of step (1) into a water bath at 85°C for heating and stirring, then add 0.2 g of triacetin and 0.005 g of benzyl alcohol and continue to stir evenly, and set aside;

[0030] (4) Slowly pour the film prepared in step (3) into the nonoxynol ether solution of step (2), heat it on a water bath at 90°C and stir evenly, and pour the above-mentioned drug slurry evenly on four pieces Clean and smooth 10cm*20cm glass plate, 800cm film made by hand 2 , The film thickness is controlled at about 45um, put it in a constant temperature blast dryer at 75℃...

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Abstract

The invention discloses a nonoxynol nonylphenoxy-polyethoxyethanol film agent used for contraception, which is prepared by nonoxynol nonylphenoxy-polyethoxyethanol, film-forming material, a plasticizer, distilled water, an antiseptic and essence according to certain weight ratio; the preparation method is as follows: (1) proper amount of distilled water is added into chitosan hydrochloride, stirred evenly, rested and fully expanded; (2) the plasticizer and the essence are added into the nonoxynol nonylphenoxy-polyethoxyethanol and evenly stirred; (3) the film-forming material in step (1) is heated in water bath and proper amount of the plasticizer and the antiseptic are added and evenly stirred, then added into the main medicament dissolved in the step (2), and then arranged on the water bath, heated and stirred fully; and (4) the medicine slurry is fully paved on a glass board by a board scraping method, blown and dried, thus instantly forming the film. The nonoxynol nonylphenoxy-polyethoxyethanol film agent prepared by the invention takes the chitosan hydrochloride as the film-forming material; the chitosan hydrochloride has excellent biocompatibility and biological degradability; the decomposed product is innoxious, is small in thrill, convenient in use, high in safety and simple in preparation technique; and a pharmacological test result shows that the contraception effect is remarkable.

Description

Technical field [0001] The invention belongs to the field of chemical preparations, and specifically relates to a nonoxynol ether film for contraception and a preparation method thereof. Background technique [0002] Family planning is our country's basic national policy, and contraception involves every family. Reproduction is a complex process, including the formation, maturation, discharge, fertilization, implantation and embryo development of sperm and eggs. Blocking any of these links can achieve the purpose of contraception or termination of pregnancy. Because oral contraceptives often interfere with endocrine, cause nausea, vomiting, and even irregular vaginal bleeding and other side effects, thus limiting the scope of use. The topical contraceptives do not interfere with endocrine function and are reversible. Therefore, the research work of topical contraceptives is paid more attention. External contraceptives are suitable for women of all age groups and levels, with rela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/085A61P15/18
Inventor 李海涛冷玉静
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE