Unlock instant, AI-driven research and patent intelligence for your innovation.

Use of ursolic acid and plant extract containing the same

A technology of plant extracts and ursolic acid, which can be used in applications, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as liver and kidney function damage, prevent and treat diabetes and obesity, and reduce sugar intake. Injection, the effect of suppressing the rise of blood sugar level

Inactive Publication Date: 2009-05-06
上海市新文达生物科技有限公司
View PDF1 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the side effects of the above-mentioned types of drugs, there is a big controversy about whether insulin therapy will produce drug dependence symptoms; metformin has different degrees of damage to liver and kidney functions, and at the same time, it is also contraindicated in the use of hypertensive patients and elderly diabetic patients ; And sugar worship (inhibiting the activity of α-glucosidase) has no side effects except that the situation of hypoglycemia needs to be monitored, and sugar worship medicines also have a very positive effect on improving the quality of life of patients You can enjoy sugary foods relatively more while taking medicine)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of ursolic acid and plant extract containing the same
  • Use of ursolic acid and plant extract containing the same
  • Use of ursolic acid and plant extract containing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 The preparation of the rosemary extract containing WRY compound and WRY compound

[0034] 1. Preparation of rosemary extract

[0035] Grind 1000 grams of dried rosemary (produced in Jiangxi) leaves and stems into dry powder, soak and extract in petroleum ether twice (45°C, 2h / time); recover petroleum ether; dry residue, 95% ethanol (weight of residue: 95% ethanol weight = 1:10) extract and dry the slag twice (65°C, 2h / time); filter to obtain the alcohol extract; the alcohol extract is directly concentrated under reduced pressure to a dry product to obtain 50 grams, the dry product is Rosemary extract.

[0036] 2. Preparation of WRY compounds

[0037] Take 10 grams of the above-mentioned rosemary extract to isolate the WRY compound, and obtain 500 mg of the pure WRY compound. The content of the WRY compound in the rosemary extract is 5 wt%.

[0038] The separation method of WRY is according to the reference: the preparation method of extracting ursolic ac...

Embodiment 2

[0039] Example 2 Rosemary extract containing WRY compound and WRY compound inhibit test of α-glucosidase activity

[0040] 1. Test principle: The degradation effect of α-glucosidase on α-glucoside is tested by a spectrophotometer, so as to detect the inhibitory effect of the sample on the activity of α-glucosidase.

[0041] 2. Test conditions:

[0042]Instruments: 722-type grating spectrophotometer (manufactured by Shanghai Third Analytical Instrument Factory), electric heating constant temperature water bath (Shanghai Jinghong Experimental Equipment Co., Ltd.), microanalytical balance AE240 (manufactured by Mettler-Toledo, Switzerland), PHB- Type 1 portable PH / ORP meter (manufactured by Shanghai Sanxin Instrument Factory); main reagents: α-glucosidase (Sigma Company of the United States), α-p-nitrophenol glucoside (Sigma Company of the United States), 1,3-butanediol , Sodium Hydroxide, Disodium Hydrogen Phosphate, Potassium Dihydrogen Phosphate (manufactured by Shanghai Reag...

Embodiment 3

[0047] Embodiment 3: The rosemary extract containing WRY compound and WRY compound are to the verification experiment of the rat that inhibits the blood sugar rise caused by oral starch

[0048] 1. Configuration of experimental samples

[0049] Experimental solution 1: 900mg of WRY compound + 900mg of gum arabic + purified water to 90ml.

[0050] Experimental solution 2: 1800 mg of rosemary extract obtained in Example 1 + 900 mg of gum arabic + purified water to 90 ml.

[0051] Control solution: Gum Arabic 900mg + purified water to 90ml.

[0052] Starch paste: 200g of edible starch + 500ml of purified water, stir, heat, and dissolve until a uniformly distributed paste.

[0053] Experimental solution 1 is calculated on the basis of a 60-kg adult, and the recommended dosage per serving is 0.5ml / kg.b.w, with a medium-dose group; experimental solution 2 is calculated on the basis of a 60-kg adult, and the recommended dosage per serving is 0.5ml / kg .b.w, set up a medium-dose gro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a compound ursolic acid disclosed in a formula 1 or the application of a plant extract containing the compound in preparing a digestion-related enzyme activity inhibitor and preparing the medicines, drinks, foods and health products for inhibiting the rising of sugar content in blood, preventing and controlling or curing diabetes or adiposity, or for losing weight, beautifying and shaping body. The application of the invention develops the new application field of the compound and simultaneously provides a new approach for preventing, controlling and curing as well as health care in the fields.

Description

technical field [0001] The invention relates to a new application of a compound and a plant extract containing it, in particular to ursolic acid and a new application of a plant extract containing the compound. Background technique [0002] Diabetes is a metabolic, lifelong disease, and its complications seriously threaten human health. The number of deaths caused by diabetes complications ranks third in developed countries after cardiovascular and cerebrovascular diseases and cancer. Diabetes is caused by the absolute or relative insufficient secretion of insulin (the only hypoglycemic hormone in the body) and the decreased sensitivity of target tissue cells to insulin, which causes a series of metabolic disorders such as protein, fat, water and electrolytes, among which hyperglycemia as the main symbol. At present, there is no fundamental solution to the treatment of diabetes clinically. In the usual methods of prevention, control and treatment, suppressing the increase...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K36/53A61P3/10A23L1/30A23L33/105
Inventor 刘桂云骆滨
Owner 上海市新文达生物科技有限公司