Halenia ellipitica D.Don. total di-phenylcumalin drop-pills for treating chronic hepatitis and preparation method thereof
An elliptical leaf flower anchor and a technology for chronic hepatitis, which can be applied to medical preparations with inactive ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of complex ingredients, low technical content, poor safety and stability, and the like, Achieve high bioavailability, clear total ketones) and good uniformity
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Embodiment 1
[0026] 1 prescription
[0027] total Ketone active ingredient 3.0g( Ketoglycoside 0.5g Ketoglycosides 2.5g)
[0028] PEG4000 3g
[0029] PEG6000 6g
[0030] Distilled water 0.36g
[0031] Made 330 dropping pills altogether.
[0032] 2 preparation method:
[0033] Heat 0.36g of distilled water to 60°C, add 3g of total Ketone active ingredient, stir evenly, mix 3g PEG4000 and 6g PEG6000 evenly, melt in 75°C water bath, mix the total The ketone active ingredient was added into melted polyethylene glycol, and ultrasonicated for 20 minutes to make the total Completely dissolve ketone polyethylene glycol, remove air bubbles, bathe in 95°C water bath for 1h-2h, evaporate water, keep warm at 95°C and drip. Dropping conditions: use liquid paraffin as coolant, cooling column length is 80cm, coolant temperature is 10°C, inner diameter of drop opening is 2.5mm, outer diameter is 3.1mm, dropping temperature is 95°C, drop distance is 4cm, drop speed is 30 drops / min. Each ...
Embodiment 2
[0035] 1 prescription
[0036] total Ketone active ingredient 3.0g( Ketoglycoside 0.5g Ketoglycosides 2.5g)
[0037] PEG4000 4g
[0038] PEG6000 8g
[0039] Distilled water 0.45g
[0040] Make 500 dropping pills altogether.
[0041] 2 preparation method:
[0042] Heat 0.45g of distilled water to 60°C, add total Ketone active ingredient, stir evenly, mix 4g PEG4000 and 8g PEG6000 evenly, melt in 75°C water bath, mix the total The ketone active ingredient was added into melted polyethylene glycol, and ultrasonicated for 20 minutes to make the total Completely dissolve the ketone active ingredient, remove air bubbles, bathe in 95°C water bath for 1h-2h, evaporate the water, and drip at 95°C. Dropping conditions: use liquid paraffin as coolant, cooling column length is 80cm, coolant temperature is 10°C, inner diameter of drop opening is 2.5mm, outer diameter is 3.1mm, dropping temperature is 90°C, drop distance is 4cm, drop speed is 30 drops / min. Each pill conta...
Embodiment 3
[0044] 1 prescription
[0045] total Ketone active ingredient 5.0g( Ketoglycoside 1g Ketoglycosides 4g)
[0046] PEG4000 5g
[0047] PEG6000 10g
[0048] Distilled water 0.60g
[0049] Make 600 drop pills altogether.
[0050] 2 preparation method:
[0051] Heat 0.60g of distilled water to 60°C, add 5g of total Ketone active ingredient, stir evenly, mix 5g PEG4000 and 10g PEG6000 evenly, melt in 75°C water bath, mix the total The ketone active ingredient was added into melted polyethylene glycol, and ultrasonicated for 20 minutes to make the total Completely dissolve the ketone, remove air bubbles, take a water bath at 95°C for 1h-2h, evaporate the water, and drip at 95°C. Dropping conditions: use liquid paraffin as coolant, cooling column length is 80cm, coolant temperature is 10°C, inner diameter of drop opening is 2.5mm, outer diameter is 3.1mm, dropping temperature is 85°C, drop distance is 4cm, drop speed is 30 drops / min. Each pill contains 8.3mg of tota...
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