Halenia ellipitica D.Don. total di-phenylcumalin drop-pills for treating chronic hepatitis and preparation method thereof

Abstract

The invention discloses dripping pills made from halenia elliptica total flavonoids and a preparation method thereof. The dripping pills are composed of 20-30% of total flavonoids active component, 15-30% of polyethylene glycol 4000 and 40-65% of polyethylene glycol 6000 in terms of percentage by weight. The total flavonoids active component from halenia elliptica as raw materials is made by a solid dispersion technique in the modern pharmaceutical technology. Because molecules of the total flavonoids active component are uniformly dispersed in chemical crystal lattices of medical polyethylene glycol, effective area of drug molecules is greatly increased, total flavonoids dripping pills are quickly dissolved and absorbed by gastrointestinal tracts after being taken. The dripping pills are high and quick in efficiency, have good evenness, high bioavailability, clear effective components and high content of effective components.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine oral preparation for treating liver and gallbladder diseases such as chronic hepatitis and acute cholecystitis, in particular to a total active ingredient extracted from ellipse-leaf flower anchor. A drop pill made of ketone and a preparation method thereof. Background technique [0002] Halenia elliptica D.Don. is a plant of the genus Halenia in the family Gentianaceae, a species of Capillary elliptica, also known as Hepatitis. Annual herb, erect, 16-60cm high, with branched roots, yellow or brown. Slight gas, bitter taste, slightly astringent. Produced in Tibet, Qinghai, Yunnan, Gansu and other places. The Tibetan medicine is called "Jihedi". According to "Drug Standards of the Ministry of Health of the People's Republic of China (Tibetan Medicine)", "Chinese Materia Medica", "Chinese National Medicine Annals" and other records, its whole herb or aerial parts have the functions of clear...

AI Technical Summary

Problems solved by technology

So far, although there are many researches and developments on these Chinese unique Tibetan medicinal materials and industrialized production, most of them are simple processing of crude extracts or extracts, the technical content is generally relatively low, and the research on the material basis is not yet deep. Its pharmacodynamic active ingredients and mechanism of action are still unclear, and there is a lack of effective separation and purification of active ingredients and chemical characterization

In terms of preparations, most of them are simple processing of the crude extract of Anchor ellipse or forming compound preparations with other drugs. Although they have certain curative effects, they also have many disadvantages: complex ingredients, unclear active ingredients, low content of active ingredients, and large toxic and side effects. , The clinical effect is not significant

The ability to innovate in dosage forms is very weak, mainly traditional tablets, capsules and pills, which have many shortcomings: large dosage, inaccurate dosage, poor safety and stability, deficiencies in preparation technology and quality control, and the ability to form economies of scale There are very few new varieties with high technological content, the low-level duplication of single varieties and similar varieties is serious, the lack of innovative flat varieties that meet market demand, and it is difficult to gain an advantage in today's fierce market competition. These shortcomings have seriously hindered my country's The Process of Tibetan Yinchen Products to the International Market

With the development of the modernization of traditional Chinese medicine and the continuous improvement of the safety, stability and controllability of traditional Chinese medicine preparations, these preparations no longer meet the requirements of modern Chinese medicine

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