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Mono-layer oxidized mineral carbon and ferriferrous oxide composite material as well as preparation and application

A technology of triiron tetroxide and hybrid materials, which is applied in the field of material chemistry to achieve the effects of high-efficiency loading, large specific surface area and good dispersibility

Inactive Publication Date: 2009-07-08
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many researchers have prepared magnetic Fe3O4 particles with various structures, or wrapped them in silica, polymers, liposomes, etc. to achieve targeted delivery, but most of them can only achieve one target. To transport

Method used

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  • Mono-layer oxidized mineral carbon and ferriferrous oxide composite material as well as preparation and application
  • Mono-layer oxidized mineral carbon and ferriferrous oxide composite material as well as preparation and application
  • Mono-layer oxidized mineral carbon and ferriferrous oxide composite material as well as preparation and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0034]The second step: determination of carboxyl content in single-layer graphite oxide. specifically:

[0035] Disperse 49.8 mg of single-layer graphite oxide into 10 mL of 0.103 N sodium hydroxide solution, stir for 48 hours under nitrogen protection, then put the mixture into a dialysis bag and dialyze in aqueous solution until the dialyzed fluid is neutral, and the dialyzed The solution is collected together and concentrated, and finally titrated to neutrality with 0.108N hydrochloric acid solution, and the titration end point is detected with a pH meter. The content of carboxyl groups in the single-layer graphite oxide was calculated to be 8.1 mol%.

[0036] The third step...

Embodiment 2

[0044] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0045] The second step: determination of carboxyl content in single-layer graphite oxide. Specifically with embodiment 1.

[0046] The third step: preparation of single-layer graphite oxide-triferromagnetic nanoparticle composite hybrid material. specifically:

[0047] Disperse 40 mg of single-layer graphite oxide in 100 mL of dilute sodium hydroxide solution, adjust the pH to 12, react for 12 hours, and dialyze with a dialysis bag until the dialyzed fluid becomes neutral. Use nitrogen to protect the single-layer graphite oxide aqueous solution with carboxylic acid sodium salt, add nitrogen-protected 18mg hexahydrate ferric chloride and 400mg tetrahydrate ferric chloride mixtur...

Embodiment 3

[0052] The first step: Synthesize single-layer graphite oxide material, the preparation process can refer to (ACSNano, 2008, 2, 463-470); the core of this step is to obtain single-layer graphite oxide material. Similarly, other methods for obtaining single-layer graphite materials can also be used.

[0053] The second step: determination of carboxyl content in single-layer graphite oxide. Specifically with embodiment 1.

[0054] The third step: preparation of single-layer graphite oxide-triferromagnetic nanoparticle composite hybrid material. specifically:

[0055] Disperse 40 mg of single-layer graphite oxide in 100 mL of dilute sodium hydroxide solution, adjust the pH to 12, react for 12 hours, and dialyze with a dialysis bag until the dialyzed fluid becomes neutral. Use nitrogen to protect the single-layer graphite oxide aqueous solution with carboxylic acid sodium salt, add nitrogen-protected 36mg hexahydrate ferric chloride and 600mg tetrahydrate ferric chloride mixtur...

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Abstract

The invention relates to a monolayer graphite oxide and magnetic ferroferric oxide nano-particle composite hybrid material, and a preparation method and application thereof. The monolayer graphite oxide and magnetic ferroferric oxide nano-particle composite hybrid material is made from raw materials of monolayer graphite oxide material and a mixture of bivalent malysite and ferric malysite by a chemical deposition method. The preparation method comprises the steps as follows: the monolayer graphite oxide is dispersed in sodium hydroxide aqueous solution to obtain monolayer graphite oxide with sodium carboxylate; then ion exchange is carried out on the mixture of monolayer graphite oxide and the bivalent malysite and the ferric malysite under the protection of nitrogen; the processed mixture is deposited by sodium hydroxide solution after excessive malysite is removed to obtain a solid product; and the solid product is separated out and dried to obtain superparamagnetic monolayer graphite oxide and ferroferric oxide nano-particle composite hybrid material. The material is used for loading drug to obtain an efficient controllable targeted drug carrier with the magnetic property of pH response. The invention has wide application prospect in the aspects of multiple targeted drug delivery, and the separation, the purification, the inspection and the like of nuclear magnetic resonance contrast medium, DAN, protein, etc.

Description

technical field [0001] The present invention relates to a single-layer graphite oxide and ferric oxide composite material and its preparation and application, specifically superparamagnetic single-layer graphite oxide and ferric oxide nanoparticle composite hybrid material and its preparation method and application, belonging to field of materials chemistry. Background technique [0002] Since the single-layer graphite (Graphene) was successfully discovered in 2004, due to its ideal two-dimensional structure, unique electronic properties, thermal properties, optical properties, etc., it has great application prospects in the fields of physics, chemistry and materials. It has begun to attract widespread attention. The single-atom thickness and two-dimensional planar structure of single-layer graphite provide its large specific surface area, which can be used to load a large number of various molecules, including various metals, biomolecules, fluorescent molecules and various...

Claims

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Application Information

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IPC IPC(8): A61K47/02
Inventor 杨晓英陈永胜马延风黄毅张小岩
Owner TIANJIN MEDICAL UNIV
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