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Quality control method of near-infrared holographic fingerprint for pills of six ingredients with rehmannia

A quality control method, the technology of Liuwei Dihuang Pills, is applied in the measurement of color/spectral properties, medical preparations containing active ingredients, pill delivery, etc., which can solve the problem of evaluating and controlling the quality of Liuwei Dihuang Pills and ensuring the stability of Liuwei Dihuang Pills. , uneven quality and other problems, to achieve the effect of improving quality control standards, easy to master, and good reproducibility

Inactive Publication Date: 2009-07-22
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many manufacturers of Liuwei Dihuang Pills on the market, the quality of which is uneven, so the stability of Liuwei Dihuang Pills is difficult to guarantee
The 2005 edition of the Chinese Pharmacopoeia stipulates that the quality of Liuwei Dihuang Pills can be identified by determining the content of paeonol in Moutan cortex and loganin in Cornus officinalis. This method cannot evaluate and control the quality of Liuwei Dihuang Pills as a whole. Liuwei Dihuang pill determination method steps are cumbersome, time-consuming and expensive

Method used

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  • Quality control method of near-infrared holographic fingerprint for pills of six ingredients with rehmannia
  • Quality control method of near-infrared holographic fingerprint for pills of six ingredients with rehmannia
  • Quality control method of near-infrared holographic fingerprint for pills of six ingredients with rehmannia

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Experimental program
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Effect test

preparation example Construction

[0023] (1) Preparation of the test product: take the commercially available Liuwei Dihuang condensed pills, pulverize them, pass through a 100-mesh sieve, weigh 10g, and set aside;

[0024] (2) Preparation of standard products: crush Rehmannia glutinosa, Chinese yam, Cornus officinalis, Cortex Moutan, Alisma and Poria respectively, and pass through a 100-mesh sieve; take 8g of rehmannia glutinosa, 4g of Chinese yam, 4g of Cornus officinalis, and 3g of peony according to the provisions of the 2005 Pharmacopoeia Mix skin, 3g Alisma and 3g Poria cocos evenly, make standard Liuwei Dihuang Wan, set aside;

[0025] (3) Spectra of the test product and standard product: Put 10g of the test product and the standard product into the quartz sample cup respectively, and use the diffuse reflectance accessory of the integrating sphere to collect the near-infrared spectrum. -1 , the light source is attenuated by an empty gate, the gain is 2 times, and the gold foil is used as a reference to ...

Embodiment 1

[0031] Take samples of Liuwei Dihuang Concentrated Pills produced by manufacturers marked 8, 9, and 10, crush them, pass through a 100-mesh sieve, weigh 10g, and set aside; measurement method: put 10g of samples directly into a quartz sample cup, and use an integrating sphere diffuse reflectance accessory Collect near-infrared spectra. Acquisition conditions: the acquisition spectrum range is 10000 ~ 4000cm -1 , the light source is attenuated by an empty gate, and the gain is 2 times; the gold foil is used as a reference to scan, the number of scans is 32 times, and the resolution is 8cm -1 ; Collect 20 spectra for each sample; Quality identification: replace the near-infrared spectrum data of manufacturer 1 in the basic model of mass analysis with the near-infrared spectrum data measured by the samples of Liuwei Dihuang Concentrated Pills produced by the three manufacturers of 8, 9, and 10 , processed with the data analysis software TQAnalyst 8.0, established the quality ana...

Embodiment 2

[0037] Take Liuwei Dihuang Concentrated Pills of three batch numbers (batch numbers 071289, 080286, 080319) produced by the manufacturer marked 1, pass through a 100-mesh sieve, weigh 10g, and set aside; measurement method: put the sample directly into the quartz sample cup , near-infrared spectra were collected using an integrating sphere diffuse reflectance accessory. Acquisition conditions: the acquisition spectrum range is 10000 ~ 4000cm -1 , the light source is attenuated by an empty gate, and the gain is 2 times; the gold foil is used as a reference to scan, the number of scans is 32 times, and the resolution is 8cm -1 , 20 spectra were collected for each sample; quality identification: the near-infrared spectrum data measured by the above three batches of Liuwei Dihuang Concentrated Pills were replaced successively by the near-infrared spectrum data of No. 1 in the basic model of quality analysis of Liuwei Dihuang Pills. The analysis software TQ Analyst 8.0 was used fo...

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Abstract

The invention relates to a method for controlling quality of a near-infrared holographic fingerprint spectrum of a pill of six ingredients with rehmannia. The method combines fingerprint spectrum technology with the characteristics of a detected composition, utilizes a near-infrared spectrum to carry out analysis and detection of physicochemical property on all samples relevant to hydrogen contained groups, and ensures that the detected composition is accurate and reliable. The application of near-infrared spectrum detection and a chemometrics method can more accurately grasp the whole quality of relevant drugs, thereby effectively ensuring safety, uniformity, stability, effectiveness and controllability of the pill of six ingredients with rehmannia. The method for controlling the quality has simplicity and convenience, an accurate result, and good repeatability, can be used for quality evaluation, quality control and new medicine development of traditional Chinese medicine, and in particular can be used as one of indexes for quality control and truth authentication of the pill of six ingredients with rehmannia.

Description

technical field [0001] The invention belongs to the field of detecting traditional Chinese medicine preparations by using modern analysis and detection instruments, and relates to a quality control method of traditional Chinese medicine, in particular to a quality control method of the near-infrared holographic fingerprint of Liuwei Dihuang Pills. Background technique [0002] Liuwei Dihuang Pill is a representative prescription for nourishing kidney yin in TCM tonics. Its formula is derived from classic ancient prescriptions. It is composed of six medicinal materials: Rehmannia glutinosa, Cornus officinalis (made), Moutan cortex, Alisma, yam, and Poria cocos. It has the effect of nourishing yin and nourishing kidney. The main function. Kidney, liver, and spleen are combined to nourish the three yin, mainly tonifying the kidney; Rehmannia glutinosa nourishes kidney yin, replenishes essence and marrow as the main medicine; Cornus officinalis is sour and warm in nature, can no...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/16A61K9/20A61K9/48A61P1/14G01N21/35
Inventor 杨天鸣付友珍
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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