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Preparation method of Chinese medicine emplastrum for expelling rheumatism and relieving pain

A technology of traditional Chinese medicine paste and rheumatism, which is applied in the field of medicine, can solve the problems of active ingredient destruction, long production cycle, and environmental pollution, and achieve the effects of reduced solvent consumption, reduced energy consumption, and high extraction rate

Active Publication Date: 2009-07-22
XIUZHENG PHARMA GROUP HOIDING
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AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a preparation method of a traditional Chinese medicine plaster for dispelling rheumatism and relieving pain, which is used for the preparation of "Shangshi Pain Relief Plaster", which overcomes the low extraction rate and easy destruction of active ingredients in the existing preparation method; Long production cycle, high energy consumption, high cost, and insufficient environmental pollution

Method used

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  • Preparation method of Chinese medicine emplastrum for expelling rheumatism and relieving pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Take 180g of raw Aconitum aconiti, 180g of Shengcaowu, 180g of ephedra, 360g of herb, 360g of angelica, 229g of Angelica dahurica, 485g of dried ginger, 146g of kaempferia, 114g of star anise, 80g of menthol, 60g of borneol, 40g of camphor, salicylic acid Methyl ester 60g spare;

[0023] 2. Grind the nine flavors of raw Chuanwu, Shengcaowu, ephedra, atractylodes, angelica, angelica, dried ginger, kaempferen, star anise, etc. taken in step 1 into 30-mesh coarse powder, and set aside;

[0024] 3. The coarse powder obtained in step 2 is extracted 3 times with 85% ethanol under high pressure, and the amount of alcohol used is 12 times, 10 times, and 8 times of the weight of the medicinal powder respectively, and the pressure is 100 MPa, and the pressure is kept for 3 minutes each time, and combined The extract is recovered from ethanol, concentrated to an extract with a relative density of 1.16 (thermally measured at 55°C), and set aside;

[0025] 4. Add the menthol, bo...

Embodiment 2

[0028] 1. Take 180g of raw Aconitum aconiti, 180g of Shengcaowu, 180g of ephedra, 360g of herb, 360g of angelica, 229g of Angelica dahurica, 485g of dried ginger, 146g of kaempferia, 114g of star anise, 80g of menthol, 60g of borneol, 40g of camphor, salicylic acid Methyl ester 60g spare;

[0029] 2. Grind the raw materials of step 1, such as Shengchuanwu, Shengcaowu, ephedra, atractylodes, angelica, angelica, dried ginger, kaempferia, star anise, etc., into 60-mesh coarse powder, and set aside;

[0030] 3. The coarse powder obtained in step 2 is extracted 3 times with 85% ethanol under high pressure, and the amount of alcohol used is 8 times, 6 times, and 6 times of the weight of the medicinal powder respectively, and the pressure is 200 MPa, and the pressure is maintained for 4 minutes each time, and the extracts are combined. Recover ethanol, concentrate to the extract whose relative density is 1.20 (measured at 58°C), and set aside;

[0031] 4. Add the menthol, borneol, c...

Embodiment 3

[0034] 1. Take 180g of raw Aconitum aconiti, 180g of Shengcaowu, 180g of ephedra, 360g of herb, 360g of angelica, 229g of Angelica dahurica, 485g of dried ginger, 146g of kaempferia, 114g of star anise, 80g of menthol, 60g of borneol, 40g of camphor, salicylic acid Methyl ester 60g spare;

[0035] 2. Grind the raw materials of step 1, such as Shengchuanwu, Shengcaowu, ephedra, atractylodes, angelica, angelica, dried ginger, kangaroo, star anise, etc., into 40-mesh coarse powder, and set aside;

[0036] 3. The coarse powder prepared in step 2 was extracted 3 times with 85% ethanol under high pressure, and the amount of alcohol used was 10 times, 8 times, and 6 times the weight of the medicinal powder respectively, and the pressure was 150 MPa. The pressure was maintained for 5 minutes each time, and the extraction was combined. liquid, reclaim ethanol, concentrate to the extract whose relative density is 1.21 (measured at 60°C), and set aside;

[0037] 4. Add menthol, borneol,...

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Abstract

The invention relates to a method for preparing traditional Chinese medicine emplastrum for expelling wind-damp and stopping pain, and belongs to the technical field of medicines. The method is used for preparing 'a pain-relieving plaster for injury and rheumatism', and overcomes the defects that effective ingredients are easy to be damaged by high temperature, the extraction rate is low and the environment is polluted in the prior reflux extraction. The method comprises: taking dried radix aconite, dried radix aconiti feri, Chinese ephedra, Atractylodes chinensis, Chinese angelica, Angelica dahurica, dried ginger, Kaempferia galangal, Chinese anise, mentha-camphor, borneol, camphor and methyl salicylate according to the mixture ratio of given raw materials; crushing the dried radix aconite, the dried radix aconiti feri, the Chinese ephedra, the Atractylodes chinensis, the Chinese angelica, the Angelica dahurica, the dried ginger, the Kaempferia galangal and the Chinese anise into coarse powder with the granularity between 30 and 60 meshes, using alcohol to perform ultrahigh pressure extraction, reclaiming the ethanol, concentrating an extract, and obtaining an extract; and adding the mentha-camphor, the borneol, the camphor and the methyl salicylate into the extract for uniform mixing, adding a substrate, and preparing the emplastrum. The method has the advantages of low-temperature ultrahigh pressure alcohol extraction, high extraction rate, undamaged active ingredients, low production cost and reduction of environmental pollution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a traditional Chinese medicine plaster for dispelling rheumatism and relieving pain. Background technique [0002] Rheumatic pain is a common and difficult disease recognized worldwide. Headache, rheumatic pain, neuralgia, muscle pain and other pains have seriously affected people's normal work and life. It is more common in acute lumbar sprain, chronic lumbar muscle strain, lumbar spine Osteoarthritis, lumbar disc herniation, sciatica, acute neck soft tissue injury, chronic strain of neck and shoulder soft tissue, cervical spondylosis and frozen shoulder, etc., patients suffer from long-term pain, and severe cases cannot take care of themselves, seriously affecting their Quality of Life. [0003] The existing prescription is composed of raw Chuanwu, Shengcaowu, ephedra, herb, angelica, angelica, dried ginger, kaempferol, star anise, menthol,...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/70A61P29/00A61K31/045A61K31/125A61K31/618
Inventor 高文功高陆赵源慧付成国于占华
Owner XIUZHENG PHARMA GROUP HOIDING
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