A kind of preparation method of high biological activity mxene/biological glass microsphere composite material

A bio-glass and bio-active technology, which is applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve unseen problems, achieve the effects of promoting precipitation, increasing deposition, and broad industrialization prospects
CN113398327BActive Publication Date: 2022-05-10FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2022-05-10

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Abstract

The invention discloses a preparation method of a highly bioactive MXene / biological glass microsphere composite material. MXene was prepared by in situ synthetic hydrofluoric acid etching method, followed by sol-gel method combined with template method to prepare bioglass microspheres, and finally MXene / bioglass microsphere composites were prepared by electrostatic self-assembly method. Since the surface of MXene has special surface groups, including polar groups such as hydroxyl (‑OH), oxygen (‑O) or fluorine (‑F), these groups can be used as active sites after compounding with bioglass, which can Promote the increase of hydroxyapatite precipitation, and MXene has a high surface charge (negative Zeta potential exceeding ‑40 mV), which can absorb Ca and P plasma in body fluid faster and accelerate the formation of hydroxyapatite precipitation, so MXene / Bioglass microsphere composite material has high biological activity.
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Description

technical field

[0001] The invention belongs to the field of biological functional materials, and in particular relates to a preparation method of a high biological activity MXene / biological glass microsphere composite material. Background technique

[0002] At present, traditional autologous bone grafting and allogeneic bone grafting are commonly used in clinical treatment of patients with bone defects. However, due to the limited source of autologous bone transplantation and insufficient donors, allogeneic bone transplantation also has certain risks of immune rejection and disease infection. Bioglass has good in vitro mineralization properties. After soaking in simulated body fluid for a period of time, bone-like hydroxycarbonate crystals can be formed on its surface, and can form a good chemical bond with human bone. The osseointegration performance of bioglass is mainly because after the glass substrate is immersed in body fluid, the hydroxyapatite generated on its surf...

Claims

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