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Dripping pill for relieving cough and asthma and preparation method thereof

A technology for relieving cough, relieving asthma, and dropping pills, which is applied in pill delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of capsule skin aging and other problems, and achieve easy quality control and bioavailability High effect with few side effects

Inactive Publication Date: 2009-09-09
BEIJING ZHONGKE RENHE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin is mostly used as the capsule body material for the preparation of capsules. Due to the characteristics of gelatin and the preparation technology, the outer skin of the capsule is prone to aging during the storage of capsules, which will produce certain insoluble substances in the human body. Residues in the human body will have a certain impact on the health of the human body. Therefore, many international and domestic medical workers are constantly conducting in-depth research in order to seek to improve this phenomenon.

Method used

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  • Dripping pill for relieving cough and asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (a) According to the 1:7 ratio of medicinal ingredients and matrix, respectively weigh 25 g of vitex oil, 10 g of mugwort leaf oil, 12 g of licorice liquid extract and 330 g of polyethylene glycol (4000), and first mix polyethylene glycol ( 4000) placed in a heating container, heated to a molten state, adding vitex oil, mugwort oil, licorice liquid extract in stages, and stirring evenly;

[0021] (b) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0022] (c) When the temperature of the dripper and the condensing agent of the dripping pill machine have been stabilized in the required state of the second step, pass the melted material through the dripper of the dripping pill machine (dropper diameter: 2mm / 4.2mm) to Drop into the methyl silicone oil a...

Embodiment 2

[0025] (a) According to the ratio of 1:5 between the effective ingredients and the matrix, weigh 25 g of vitex oil, 10 g of total alkaloids of pea root, 160 g of polyethylene glycol (4000) and 10 g of polyethylene glycol (20000), stearin sodium stearate 5g, first polyethylene glycol (4000) and polyethylene glycol (20000), sodium stearate are placed in the heating container, heated to molten state, add oyster oil, total alkaloid of pea root in portions, stir Uniform;

[0026] (b) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0027] (c) When the temperature of the dripper and the condensing agent of the dripping pill machine have been stabilized in the required state of the second step, pass the melted material through the dripper of the dripping pill mac...

Embodiment 3

[0031] (a) According to the ratio of 1:3 between the active ingredient and the matrix, weigh 25g of Vitex oil, 0.5g of Tween-80, 40g of polyethylene glycol (6000), 35g of polyethylene glycol (4000), first Put Tween-80, polyethylene glycol (6000), and polyethylene glycol (4000) in a heating container, heat to a molten state, add vitex oil, and stir evenly;

[0032] (b) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0033] (c) When the temperature of the dripper and the condensing agent of the dripping machine have been stabilized in the state required in the second step, pass the melted material through the dripper of the dripping machine (the inner diameter of the dropper mouth: 2 ~ 4mm), and Drop into the methyl silicone oil at an appropriate speed;

...

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Abstract

The invention discloses a dripping pill for relieving cough and asthma and a preparation method thereof. A Chinese medicament dropping pill is a novel formulation developed on the basis of a Chinese medicament pill recently, which is based on Chinese medicament theory, absorbs advantages of modern formulations, is combined with other preparation technology, and basically accords with the development direction of modern preparations of 'three effective' (high effective, quick effective and long effective), 'three small' (small toxicity, small reaction and small dosage) and 'five convenient' (production, transportation, use, carrying and storage), so the Chinese medicament dropping pill is developed rapidly. The dripping pill has the characteristics of high bioavailability, good curative effect, small side effect, good medicament stability, simple preparation, easy quality control and the like.

Description

technical field [0001] The invention belongs to the field of Chinese patent medicine drop pill preparations, in particular to a drop pill for relieving cough and relieving asthma, and also relates to a preparation method of the drop pill. Background technique [0002] Vitex oil capsules are recorded on page 473 of the Chinese Pharmacopoeia (2005 edition). Commonly used oral pharmaceutical preparations for bronchitis. Gelatin is mostly used as the capsule body material for the preparation of capsules. Due to the characteristics of gelatin and the preparation technology, the outer skin of the capsule is prone to aging during the storage of capsules, which will produce certain insoluble substances in the human body. Residues in the human body will have a certain impact on the health of the human body. Therefore, many international and domestic medical workers are constantly conducting in-depth research in order to seek improvements to this phenomenon. [0003] Chinese medicin...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/20A61K47/34A61K47/12A61P11/06A61P11/14A61K47/10
Inventor 颜丽君
Owner BEIJING ZHONGKE RENHE SCI & TECH
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