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Method for synthesizing glycocyamine and salt thereof

The technology of a guanidinoacetate and a synthetic method is applied in the synthesis field of guanidinoacetic acid and its salt, can solve the problems of low yield, complicated reaction process and the like, and achieves convenient separation and purification, simple synthesis process and easy process conditions. control effect

Active Publication Date: 2009-09-09
固安君德同创生物工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction process of this method is complex, there are excessive bromoethane and ethanol recovery problems, and the yield is not high

Method used

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  • Method for synthesizing glycocyamine and salt thereof
  • Method for synthesizing glycocyamine and salt thereof
  • Method for synthesizing glycocyamine and salt thereof

Examples

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Embodiment 1

[0043] Embodiment 1, the preparation of guanidine acetate

[0044] The present invention prepares the flow process of guanidine acetate as figure 1 Shown:

[0045] 1. Preparation of guanidine acetate

[0046]1. Preparation of free guanidine solution

[0047] Add 200gNaOH (or 265gNaOH) to 600ml water 2 CO 3 ) stirring and dissolving, cooling to below 15°C, slowly adding 480g of guanidine hydrochloride, stirring and dissolving until transparent. The free guanidine solution A can be obtained.

[0048] 2. Sodium chloroacetate solution

[0049] Add 460g chloroacetic acid in 460ml water and stir at room temperature until dissolved, add dropwise 25% (mass percentage) NaOH solution 760g (or 30% (mass percentage) NaOH solution 2 CO 3 solution 840g), stirred until completely dissolved. Sodium chloroacetate solution B can be obtained.

[0050] 3. Synthesis of guanidinoacetate

[0051] The free guanidine solution A prepared in step (1) was added dropwise to the sodium chloroace...

Embodiment 2

[0066] Embodiment 2, the preparation of guanidinoacetic acid

[0067] The synthetic route of guanidinoacetic acid is as follows: figure 2 As shown, the difference between embodiment 2 and embodiment 1 is that chloroacetic acid directly reacts with free guanidine solution to generate guanidinoacetic acid. The specific steps are as follows:

[0068] 1. Preparation of free guanidine solution

[0069] Add 250gNaOH (or 300gNaOH) to 600ml water 2 CO 3 ) stirring and dissolving, cooling to below 20°C, slowly adding 480g of guanidine hydrochloride, stirring and dissolving until transparent. The free guanidine solution A can be obtained.

[0070] Second, the formation of guanidinoacetic acid

[0071] Add 520 g of chloroacetic acid to 520 ml of water and stir at room temperature until dissolved, add dropwise to the free guanidine solution prepared in step 1, stir and react for about 24 hours, and a white solid is formed. Filter, wash with a small amount of water and ethanol, and...

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Abstract

The present invention discloses a method for synthesizing glycocyamine and salt thereof. The method for synthesizing glycocyamine salt comprises the following steps: 1) carrying out neutralization reaction on guanidine hydrochloride and an alkaline matter C for obtaining solution A; 2) facilitating chloroacetic acid to react with alkaline solution for obtaining solution B; and 3) facilitating the solution A to react with the solution B for generating glycocyamine salt. The alkaline matter C can be sodium hydroxide or sodium carbonate. Preferably the mass ratio of sodium hydroxide:guanidine hydrochloride:chloroacetic acid is 200:480:460. Preferably the mass ratio of sodium carbonate:guanidine hydrochloride:chloroacetic acid is 265:480:460. Preferably the reacting temperature of step 3) is 40 DEG C. The holding time of reaction is no less than 24 hours. The synthesis of glycocyamine refers to that the solution of step 1) directly reacts with the chloroacetic acid. The method used by the invention has the advantages of simple synthetic process, convenient operation, higher yield, less byproducts and convenient separation and purification. The product purity of the compound of the invention can be higher than 98%.

Description

technical field [0001] The present invention relates to the synthetic method of guanidinoacetic acid (GAA) and its salt. Background technique [0002] Creatine has been considered a good food / feed additive for a long time. Creatine plays an important role in the energy metabolism of animal cells. When muscles work, energy comes from adenosine triphosphate (ATP). As shown in Equation (I), at muscle rest, ATP can transfer a phosphate group to creatine to form phosphocreatine. When muscles are working, creatine phosphate can transfer the phosphate group to adenosine diphosphate (ADP) by creatine kinase to reform ATP. Therefore, creatine phosphate and ATP in the body are in a dynamic balance. [0003] [0004] Creatine mainly exists in animal protein raw materials. Adding creatine in diet can improve animal feed intake, growth performance and reproductive performance. [0005] However, the European Union stipulates that other animal protein materials except fishmeal are ...

Claims

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Application Information

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IPC IPC(8): C07C279/14C07C277/08A23K1/16A23K20/105A23L33/10
Inventor 杨立彬张德福石波
Owner 固安君德同创生物工程有限公司
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