Triad integration freckle-removing functional nano cream for skin external use and method for preparing same
A nanoemulsion and skin technology, applied in skin care preparations, cosmetic preparations, pharmaceutical formulations, etc., can solve problems such as contact dermatitis, poor control of application concentration, and improper use methods
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[0062] Example 1: Preparation of nanoemulsion with anti-freckle effect for night-use skin (take preparation of 1000g as an example)
[0063] 1. Formula composition and dosage: 131g isopropyl myristate, 307.5g caprylic acid capric acid polyethylene glycol glyceride, 102.5g polyglycerol fatty acid ester, 338.6g triple distilled water, 23.8g lactobionic acid, 23.8 gluconolactone g. Glutathione 23.8g, Coenzyme Q10 6.5g, Azone 6.5g, Vitamin E 22.9g, Symwhite-377 German high-efficiency whitening agent 13.1g.
[0064] 2. Specific preparation technology and operation method:
[0065] ① Use an analytical balance to accurately weigh 23.8g lactobionic acid into a 1000mL Erlenmeyer flask that has been cleaned up, add 338.6g triple distilled water or distilled water to fully dissolve it, then add 23.8g gluconolactone and dissolve it. Add 23.8g of glutathione, mix well at 70±5°C, and use a color marker to clearly mark the water phase (I) 410g, and use this solution as the water phase.
[0066] ...
Example Embodiment
[0071] Example 2: Daily-use nanoemulsion with anti-freckle effect for external use on skin (take preparation of 1000g as an example)
[0072] 1. Formula composition and dosage: 154.2g isopropyl myristate, 366g caprylic acid capric acid polyethylene glycol glyceride, 122g polyglycerol fatty acid ester, triple distilled water 248g, glycolic acid 34.6g, glutathione 17.4g Coenzyme Q 10 7.7g, Azone 7.7g, Vitamin E 27g, Symwhite-377 German high-efficiency whitening agent 15.4g.
[0073] 2. Specific preparation technology and operation method:
[0074] ① Use an analytical balance to accurately weigh 34.6g of glycolic acid and place it in a 1000mL Erlenmeyer flask that has been cleaned up. Then add 248g of triple distilled water or distilled water to fully dissolve it, and finally add 17.4g of glutathione to a temperature of 70± After mixing thoroughly at 5°C, use a color marker to clearly mark 300 g of the water phase (I), and use this solution as the water phase.
[0075] ②Accurately we...
Example Embodiment
[0080] Example 3: Auxiliary nanoemulsion with anti-freckle effect for external use on skin (take preparation of 1000g as an example)
[0081] 1. Formula composition and dosage: 84.7g of isopropyl myristate, 330g of caprylic acid capric acid polyethylene glycol glyceride, 110g of polyglycerol fatty acid ester, 325.6g of triple distilled water, 117g of 30% hydrogen peroxide, 11g of azone, Symwhite-377 German high-efficiency whitening agent 14.3g, citric acid 4.6g, and trisodium citrate dihydrate 2.8g.
[0082] 2. Specific preparation technology and operation method:
[0083] ① Use an analytical balance to accurately weigh 4.6g of citric acid and 2.8g of trisodium citrate dihydrate in a 1000mL Erlenmeyer flask that has been decontaminated, and then add 325.6g of triple distilled water to fully dissolve it, and finally add 117g of peroxide Hydrogen (30%), after mixing well, clearly mark as water phase (I) 450g with a colored marker, and use this solution as the water phase.
[0084] ②...
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