Triad integration freckle-removing functional nano cream for skin external use and method for preparing same

Abstract

The invention relates to a triad integration freckle-removing functional nano cream for skin external use and a method for preparing the same. The three types (night use type, daytime use type and auxiliary type) freckle-removing nano creams improve and optimize a novel international passive target transdermal drug delivery system (TDDS) as a carrier, and organically combine and solubilize freckle-removing functional components with different biological efficacies, action ways and physical and chemical properties to form a good mutual aid synergic function system which has remarkable effect of controlling and relieving colored patches (such as chloasma, inflammatory pigmentation, sunburn, and the like) caused by abnormal facial metabolism of pigment. The product has the advantages of tiny particle sizes of spherical particles, obvious passive target function, excellent adaptability, homodromous property, fluidity and dispersion, strong penetrability, even texture, subtleness, lubricity and luster, is simple and convenient to use, and is comfortable without pungency and side effects; besides, the appearance is light yellow with slight opalescence, is glittering and translucent, clear and transparent, sticky but not viscous, thick but not dense, and oily but not greasy, has good stability, excellent curative effect, short industrialization cycle and high production efficiency, saves time, materials and energy sources, dose not need special devices and heat energy, and is easy for popularization and application.

Description

technical field [0001] The present invention relates to skin pigmentation disorders, medical beauty care products and new cosmetic preparation technology, in particular to a new type of triple combination that can be successfully applied to inhibit human skin pigmentation and lighten or reduce facial skin spots, especially chloasma. Integrating nano-emulsion with freckle-removing effect for external use on skin and a preparation method thereof. Background technique [0002] (1) Background technology about skin topical freckle-removing functional ingredients: at present, about skin external-use freckle-removing functional ingredients, one is to inhibit the activity of tyrosinase, and tyrosinase (TYR) is the key enzyme of melanin production, and the activity of TYR Regulation, can directly affect the synthesis of melanin, such as: hydroquinone, retinoic acid, arbutin, hydroquinone-α-glucoside, kojic acid, methyl gentisate, L-ascorbic acid-2-phosphate Magnesium, Azelaic Acid, ...

AI Technical Summary

Problems solved by technology

Because if retinoic acid and α-hydroxy acid are added in too large concentration and the use cycle is too long, it is easy to cause irritation to skin tissue, acid allergy, phototoxicity, contact dermatitis, and even cause gene mutation, etc.

Moreover, the application concentration of retinoic acid and fruit acid is not well grasped, and the use method is improper, and direct skin burns (such as skin congestion, edema, flushing, burning pain, running water, scaling, etc.) and indirect skin burns (mainly Refers to the stimulation of sunlight on the skin in the treatment area, increasing the skin’s absorption of ultraviolet rays and the skin’s defense against ultraviolet rays); ⑦ Poor stability: the physical and chemical properties of hydroquinone, kojic acid, vitamin C and phenolic compounds are unstable, especially for Poor tolerance to external environmental factors such as light, oxygen, pH, temperature, etc., so that the content and effect of functional ingredients are significantly reduced

Moreover, due to its unstable physical and chemical properties, it is easy to make its functional ingredients oxidized or autoxidized, which will make the product color continue to deepen, which will seriously affect the appearance and internal quality of the product, and the content or concentration and molecular structure of the product will change accordingly, resulting in Further decline in product efficacy