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Oral pharmaceutical preparation of dioscorea zingiberensis wright total sapogenin and preparation method and application thereof

A technology of diosgenin and total saponins, which is applied in the field of pharmaceutical preparations, can solve the problems of ignoring the total saponins of diosgenin, and achieve the effects of improving bioavailability, facilitating absorption and utilization, and not easy to wet and absorb

Inactive Publication Date: 2009-09-16
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology has neglected the research on the total saponin of Dioscorea scutellariae, and its effect and application have been in a blank state.

Method used

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  • Oral pharmaceutical preparation of dioscorea zingiberensis wright total sapogenin and preparation method and application thereof
  • Oral pharmaceutical preparation of dioscorea zingiberensis wright total sapogenin and preparation method and application thereof
  • Oral pharmaceutical preparation of dioscorea zingiberensis wright total sapogenin and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Take 100g of total saponins of Dioscorea scutellaria, add 20g of chitosan, 10g of carbomer, 50g of poloxamer, 50g of lecithin, 30g of micropowdered silica gel, 80g of beta cyclodextrin, and add starch to 450g, vibrating mill Finely pulverized and mixed for 30 minutes, granulated, dried, granulated, and made into capsules.

Embodiment 2

[0143] Get 70g of total diosgenin and 20g of total diosgenin, add chitosan 20g, poloxamer 30g, lecithin 10g, micropowder silica gel 30g, beta-cyclodextrin 20g, microcrystalline cellulose 50g, And add starch to 300g, vibrating mill for ultrafine pulverization for 30 minutes, add 70% ethanol to combine for 10 minutes, make pellets, granulate and round, dry, polish, and make pills.

Embodiment 3

[0145] Take 120g of total saponins of Dioscorea baicalensis, add 2g of chitosan, 10g of lecithin, 1g of aspartame, and add dextrin to 200g, stir evenly, dry press granules, and pack separately to make granules.

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Abstract

The invention discloses an oral pharmaceutical preparation of dioscorea zingiberensis wright total sapogenin and a preparation method and application thereof, pertaining to the field of traditional Chinese medicine. In respect of the pharmaceutical preparation, the sapogenin obtained by hydrolyzation of sapogenin compositions in dioscorea zingiberensis wright is matched with high-efficiency medical auxiliary materials and mixed evenly by the method of micronization, and then the oral pharmaceutical preparation is produced. The pharmaceutical preparation can enhance the dispersibility, wettability and solubility of the sapogenin compositions, increase the absorption and utilization degree of the sapogenin and improve the biological utilization degree of the sapogenin, and has outstanding effects in treating diseases such as gout affection, hyperlipemia, diabetes, coronary heart disease, angina, rheumatism, depressive illness and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing total saponin in Dioscorea shield leaf, in particular to an oral pharmaceutical preparation in which saponin components in Dioscorea shield leaf are hydrolyzed into saponin as the main active ingredient and its application. It belongs to the field of traditional Chinese medicine. Background technique [0002] Dioscorea zingiberensis C.H.W right, also known as turmeric and fire head root, belongs to the rhizome group of Dioscorea genus Dioscorea of ​​the order Liliaceae. There are more than a dozen steroidal saponins, such as saponin, scutelin, and protosaplastin, and 4 steroidal saponins are obtained from the total, and diosgenin (Dio) is one of the steroidal saponins. Also known as diosgenin or diosgenin, it is the product of dioscin (dioscin) after the hydrolysis reaction to remove the sugar group (the article "Research Progress of Dioscin" by Huang Yahui and Sheng Xiaobang, published ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K31/58A61K9/16A61K9/20A61K9/48A61K47/32A61K47/34A61K47/36A61K47/40A61P3/06A61P3/10A61P9/10A61P25/24A61P29/00A61K125/00A61K47/04A61K47/10
Inventor 周小明刘国飞
Owner 北京凯瑞创新医药科技有限公司
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