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Calcium alginate composite membrane medical dressing used after injection and preparation method and application thereof

A technology of calcium alginate and composite membranes, which is applied in the field of medical materials, can solve the problems of poor mechanical properties of calcium alginate-chitosan composite membranes and brittle chitosan, and achieve the goals of promoting wound healing, structural integrity, and reducing patient pain Effect

Inactive Publication Date: 2009-12-09
官培龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the chitosan film is brittle, and the calcium alginate-chitosan composite film has poor mechanical properties, so it is necessary to use an appropriate amount of glycerin as a plasticizer to improve the mechanical strength of the film material.
[0008] In addition, there is no calcium alginate-chitosan composite film medical dressing mixed with skin disinfectants or water-soluble antibiotics today.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] After 3 g of chitosan was dissolved in 97 g of 0.5% w / w acetic acid aqueous solution, a chitosan solution containing 3% w / w was formed. 10 g of glycerin is dissolved in 90 g of water to form a 10% aqueous glycerin solution. Pour the 10% glycerin solution into the 3% chitosan solution, and stir mechanically at a high speed to obtain the chitosan mixture. After 3g of calcium alginate was dissolved in 97g of water, a sodium alginate solution containing 3% w / w was formed. Slowly add the chitosan mixed solution into the calcium alginate solution, and after stirring vigorously for 1 hour to fully react, pour the resulting mixed solution into a plexiglass mold, put it in a 30°C oven to dry, and form a film. Calcium alginate-chitosan composite film was obtained. After cutting by a special needle hole machine, it becomes a small disc with a diameter of 10mm; adheres to the transparent medical plastic, puts it in the needle hole sterile device; sterilizes with ethylene oxide. ...

Embodiment 2

[0020] The calcium alginate-chitosan composite film in embodiment 1 is cut into 5cm * 5cm size, is immersed in the iodine solution containing glycerin 10% (v / v), and the concentration of iodine in the iodine solution is 0.1mol / L . After soaking for 1-6 days, it is taken out, dried at 50°C, packaged, and sterilized by r-rays, which is the calcium alginate-chitosan iodine medical dressing.

Embodiment 3

[0022] In the chitosan acetate-glycerol aqueous solution in Example 1, add 2ml of ciprofloxacin injection and mix; the mixed solution is slowly poured into 3% calcium alginate solution, and after vigorously stirring for 1 hour to fully react, pour into plexiglass Put it into a mold, put it into an oven at 30° C. to dry, and form a film to obtain a ciprofloxacin biocomposite film.

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Abstract

The invention belongs to the medical material technical field, in particular to a calcium alginate-chitosan composite membrane medical dressing and a preparation method thereof; the preparation method comprises the following steps: mixing and stirring calcium alginate solution and chitosan acetic acid water solution containing glycerol fully, preparing films, and drying the films to obtain the dried calcium alginate-chitosan composite membrane medical dressing of the invention. The composite membrane medical dressing prepared by the method has excellent functions of hemostasis and antibiosis, wounds healing and has good mechanical strength and flexibility without toxic and side effect. The medical dressing can be used as biomedical material for clinical care, thus promoting the hemostasis of wounds, reducing the probability of wound infection and promoting the healing of wounds. Skin disinfectant or water soluble antibacterial drug can be used as admixture in the composite medical dressing prepared by the invention to improve the antibacterial and disinfect ability thereof, thus being applicable to the therapy of various surfaces of trauma or burn wounds.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a calcium alginate-chitosan composite film medical material and a preparation method and application thereof. Background technique [0002] Infusion, blood drawing, intramuscular injection, finger blood sampling and traditional Chinese medicine acupuncture or acupuncture treatment will all leave pinholes on the patient's skin. Improper treatment and care of the needle hole will lead to continued bleeding from the needle hole, and even subcutaneous congestion and bruises; there will also be pain; and even infection of the needle hole. These are all likely to cause the aftereffect of the pinhole in the patient, which is not conducive to the physical and mental recovery of the patient. [0003] At present, in the clinical treatment of skin pinholes, sterile cotton balls, wet cotton swabs containing 75% alcohol, or sterilized dry cotton swabs are often used for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L5/08C08L5/04A61L15/28A61L15/46
Inventor 官培龙张波饶蓉
Owner 官培龙
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