Alendronate sodium intestine-sol capsule and preparation method thereof

Abstract

The invention discloses an alendronate sodium intestine-sol capsule and a preparation method thereof; the intestine-sol capsule comprises the following compositions by weight parts: 10-20 parts of alendronate sodium, 70-100 parts of diluents, 0.5-5 parts of protective agents and 0.5-2 parts of lubricants. The alendronate sodium intestine-sol capsule is particularly added in the protective agents,so as to effectively prevent basic remedy from being released in oral cavity, esophagus and esophagus before reaching the absorption site of the intestinal canal, thereby improving the medicine quality, reducing the adverse reaction and improving the compliance of a patient; the preparation process is simple, the pollution to the environment is reduced by energy consumption and social cost is saved.

Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to an alendronate sodium enteric-coated capsule and a preparation method thereof. Background technique

[0002] Osteoporosis is a common and frequently-occurring disease in middle-aged and elderly people, especially in postmenopausal women. Its prevention and treatment drugs have become the focus of new drug development. Alendronate sodium is a new type of osteoporosis treatment and prevention drug, which belongs to the third generation of bisphosphonate bone resorption inhibitors.

[0003] Alendronate Sodium (Alendronate Sodium) chemical name: (4-amino-1-hydroxybutylene)-1,1-diphosphonic acid monosodium salt trihydrate, molecular structure:

[0004]

[0005] Alendronate was first developed by Istituto Gentili of Italy, and then transferred to Merck of the United States for further development. The foreign trade name is Fosamax. Since the tablet was first launched in Italy i...

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