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Seabuckthorn oil-polylactide-coglycolide copolymer microspheres and preparation method thereof

A glycolic acid copolymer, glycolic acid technology, applied in the direction of drug combination, pharmaceutical formulation, plant raw materials, etc., can solve the problem of PLGA microspheres without sea buckthorn oil, and achieve good antioxidant effect and improve the effect of embedding effect.

Inactive Publication Date: 2012-03-07
HENAN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after reviewing the literature, there is no report on seabuckthorn oil PLGA microspheres and related experimental research in China.

Method used

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  • Seabuckthorn oil-polylactide-coglycolide copolymer microspheres and preparation method thereof
  • Seabuckthorn oil-polylactide-coglycolide copolymer microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of the organic phase: pipette 4 ml of dichloromethane into a small beaker.

[0024] (2) Weighing and dissolving of PLGA: 125 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.

[0025] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.

[0026] (4) Preparation of the water phase: Weigh 2.5g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to dissolve the PVA completely .

[0027] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 10 min at a power of 150 W to obtain an O / W emulsion. Then carry out atmospheric pressure magnetic stirring a...

Embodiment 2

[0029] (1) Preparation of the organic phase: pipette 1 ml of dichloromethane and 3 ml of ethyl acetate to prepare 4 ml of the mixture, and add it to a small beaker.

[0030] (2) Weighing and dissolving of PLGA: 135 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.

[0031] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.

[0032] (4) Preparation of the water phase: Weigh 2.8g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to completely dissolve the PVA .

[0033] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 11 minutes with a power of 160W to obtain a...

Embodiment 3

[0035] (1) Preparation of the organic phase: pipette 1.5 ml of dichloromethane and 2.5 ml of ethyl acetate to prepare 4 ml of the mixture, and add it to a small beaker.

[0036] (2) Weighing and dissolving of PLGA: 145 mg of PLGA was weighed on a precision electronic balance, and added to the prepared organic phase to dissolve the PLGA.

[0037] (3) Addition of seabuckthorn oil: pipette 200 μl of seabuckthorn oil into the prepared organic phase, and sonicate for 1 min.

[0038] (4) Preparation of water phase: Weigh 3.0g of PVA that is crushed into fine powder on an electronic balance, add 25ml of double distilled water into a 150ml beaker, pour the PVA into it, and heat the beaker in a constant temperature water bath at 50°C to completely dissolve the PVA .

[0039] (5) Emulsification and preparation of microspheres: Pour the ultrasonicated organic phase into the PVA-dissolved aqueous phase, and perform ultrasonic emulsification for 12 minutes with a power of 170W to obtain an ...

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Abstract

The invention relates to seabuckthorn oil-polylactide-coglycolide copolymer microspheres and a preparation method thereof; the coated effective component in microspheres is seabuckthorn oil and the matrix component of wrappage is polylactide-coglycolide copolymer (PLGA). Polyving alcohol (PVA) is used as modifier, and the slow release PLGA microspheres can be prepared by the W / O / W double emulsionmethod (aka solvent evaporation method, solvent solidification method or solvent extraction method) under the action of mechanical agitation. Smooth microspheres surface, round and normal spheres, uniform particle size and good embedding can be observed under a microscope.

Description

technical field [0001] The invention relates to a slow-release microsphere of seabuckthorn oil as a health care substance, in particular to a seabuckthorn oil-polylactic acid-glycolic acid copolymer microsphere and a preparation method thereof. Background technique [0002] Seabuckthorn (Hippophae ham noides Linn) is a plant of the genus Hippophae ham noides Linn, also known as vinegar willow. It is a commonly used medicine in ancient Tibetan medicine and Mongolian medicine in China. Seabuckthorn oil extracted from seabuckthorn seeds has as many as 106 active ingredients, unsaturated fatty acids as high as 68%, vitamin E content greater than 1mg / g, and rich vitamin K and carotenoids. Medical research shows that seabuckthorn oil is anti-inflammatory and has a good effect on repairing the digestive system. Seabuckthorn brass has a very good effect on myocardial ischemia, hyperlipidemia, coronary arteriosclerosis, and can kill cancer cells. It is rich in superoxide dismutase (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/185A61K47/34A61P39/06A61P1/00A61P17/02
Inventor 刘国琴李崇达李琳
Owner HENAN UNIVERSITY OF TECHNOLOGY